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Protein

Eukaryotic translation initiation factor 4E type 3

Gene

Eif4e3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

ReactomeiR-MMU-1169408 ISG15 antiviral mechanism

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 3
Short name:
eIF-4E type 3
Short name:
eIF-4E3
Short name:
eIF4E type 3
Short name:
eIF4E-3
Gene namesi
Name:Eif4e3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914142 Eif4e3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876981 – 207Eukaryotic translation initiation factor 4E type 3Add BLAST207

Proteomic databases

EPDiQ9DBB5
MaxQBiQ9DBB5
PaxDbiQ9DBB5
PeptideAtlasiQ9DBB5
PRIDEiQ9DBB5

2D gel databases

REPRODUCTION-2DPAGEiQ9DBB5

PTM databases

iPTMnetiQ9DBB5
PhosphoSitePlusiQ9DBB5

Expressioni

Tissue specificityi

Only expressed in heart, skeletal muscle, lung and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000093661 Expressed in 268 organ(s), highest expression level in primary oocyte
GenevisibleiQ9DBB5 MM

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9DBB5, 1 interactor
MINTiQ9DBB5
STRINGi10090.ENSMUSP00000032151

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9DBB5
SMRiQ9DBB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 997-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni152 – 1577-methylguanosine-containing mRNA cap bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHHQ Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000059588
HOVERGENiHBG107990
InParanoidiQ9DBB5
OMAiLPTQHYW
OrthoDBiEOG091G0ISE
PhylomeDBiQ9DBB5

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPPAAAPP GANEPLDKAL SALPPEPGGV PLHSPWTFWL DRSLPGATAA
60 70 80 90 100
ECASNLKKIY TVQTVQIFWS VYNNIPPVTS LPLRCSYHLM RGERRPLWEE
110 120 130 140 150
ESNAKGGVWK MKVPKDSTST VWKELLLATI GEQFTDCAAA DDEIIGVSVS
160 170 180 190 200
VRDREDVVQV WNVNASLVGE ATVLEKIHQL LPHIAFKAVF YKPHEEHHAF

EGGRGKH
Length:207
Mass (Da):22,836
Last modified:June 1, 2001 - v1
Checksum:i0263A317BFD0A4C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122W → G in BAB24928 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY628329 mRNA Translation: AAT45741.1
AK005054 mRNA Translation: BAB23780.1
AK007268 mRNA Translation: BAB24928.1
BC027014 mRNA Translation: AAH27014.1
CCDSiCCDS20386.1
RefSeqiNP_080105.1, NM_025829.4
UniGeneiMm.32889

Genome annotation databases

EnsembliENSMUST00000032151; ENSMUSP00000032151; ENSMUSG00000093661
GeneIDi66892
KEGGimmu:66892
UCSCiuc009dbr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY628329 mRNA Translation: AAT45741.1
AK005054 mRNA Translation: BAB23780.1
AK007268 mRNA Translation: BAB24928.1
BC027014 mRNA Translation: AAH27014.1
CCDSiCCDS20386.1
RefSeqiNP_080105.1, NM_025829.4
UniGeneiMm.32889

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B6UNMR-A1-207[»]
4B6VNMR-A1-207[»]
ProteinModelPortaliQ9DBB5
SMRiQ9DBB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBB5, 1 interactor
MINTiQ9DBB5
STRINGi10090.ENSMUSP00000032151

PTM databases

iPTMnetiQ9DBB5
PhosphoSitePlusiQ9DBB5

2D gel databases

REPRODUCTION-2DPAGEiQ9DBB5

Proteomic databases

EPDiQ9DBB5
MaxQBiQ9DBB5
PaxDbiQ9DBB5
PeptideAtlasiQ9DBB5
PRIDEiQ9DBB5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032151; ENSMUSP00000032151; ENSMUSG00000093661
GeneIDi66892
KEGGimmu:66892
UCSCiuc009dbr.1 mouse

Organism-specific databases

CTDi317649
MGIiMGI:1914142 Eif4e3

Phylogenomic databases

eggNOGiENOG410IHHQ Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000059588
HOVERGENiHBG107990
InParanoidiQ9DBB5
OMAiLPTQHYW
OrthoDBiEOG091G0ISE
PhylomeDBiQ9DBB5

Enzyme and pathway databases

ReactomeiR-MMU-1169408 ISG15 antiviral mechanism

Miscellaneous databases

PROiPR:Q9DBB5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000093661 Expressed in 268 organ(s), highest expression level in primary oocyte
GenevisibleiQ9DBB5 MM

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF4E3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBB5
Secondary accession number(s): Q9D983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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