UniProtKB - Q9DBB4 (NAA16_MOUSE)
Protein
N-alpha-acetyltransferase 16, NatA auxiliary subunit
Gene
Naa16
Organism
Mus musculus (Mouse)
Status
Functioni
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.By similarity
GO - Molecular functioni
- ribosome binding Source: MGI
GO - Biological processi
- negative regulation of apoptotic process Source: MGI
- N-terminal peptidyl-methionine acetylation Source: GO_Central
- N-terminal protein amino acid acetylation Source: MGI
- protein stabilization Source: MGI
Enzyme and pathway databases
BRENDAi | 2.3.1.88, 3474 |
Names & Taxonomyi
Protein namesi | Recommended name: N-alpha-acetyltransferase 16, NatA auxiliary subunitAlternative name(s): NMDA receptor-regulated 1-like protein Short name: NARG1-like protein |
Gene namesi | Name:Naa16 Synonyms:Narg1l, Nat2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914147, Naa16 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Other locations
- cytoplasm Source: MGI
- NatA complex Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106298 | 1 – 864 | N-alpha-acetyltransferase 16, NatA auxiliary subunitAdd BLAST | 864 |
Proteomic databases
EPDi | Q9DBB4 |
MaxQBi | Q9DBB4 |
PaxDbi | Q9DBB4 |
PeptideAtlasi | Q9DBB4 |
PRIDEi | Q9DBB4 |
PTM databases
iPTMneti | Q9DBB4 |
PhosphoSitePlusi | Q9DBB4 |
Expressioni
Tissue specificityi
Highest levels in the kidney and testes. Moderate expression in the liver, thymus and skin.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022020, Expressed in embryo and 251 other tissues |
ExpressionAtlasi | Q9DBB4, baseline and differential |
Genevisiblei | Q9DBB4, MM |
Interactioni
Subunit structurei
Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022597 |
Miscellaneous databases
RNActi | Q9DBB4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 46 – 79 | TPR 1Add BLAST | 34 | |
Repeati | 80 – 113 | TPR 2Add BLAST | 34 | |
Repeati | 148 – 184 | TPR 3Add BLAST | 37 | |
Repeati | 224 – 257 | TPR 4Add BLAST | 34 | |
Repeati | 374 – 407 | TPR 5Add BLAST | 34 | |
Repeati | 408 – 441 | TPR 6Add BLAST | 34 | |
Repeati | 485 – 514 | TPR 7Add BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 629 – 633 | Poly-Glu | 5 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1156, Eukaryota |
GeneTreei | ENSGT00950000183174 |
HOGENOMi | CLU_006686_0_0_1 |
InParanoidi | Q9DBB4 |
OMAi | VNHTAIN |
OrthoDBi | 792708at2759 |
PhylomeDBi | Q9DBB4 |
TreeFami | TF106301 |
Family and domain databases
InterProi | View protein in InterPro IPR021183, NatA_aux_su IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12569, NARP1, 1 hit PF07719, TPR_2, 1 hit |
PIRSFi | PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9DBB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPCVQLPAKE SALFKRVLKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA
60 70 80 90 100
MKGLILNCLG KREEAYEFVR KGLRSDVRSH VCWHVYGLLQ RSDKKYDEAI
110 120 130 140 150
KCYRNALKLD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPTQRAS
160 170 180 190 200
WIGYAIAYHL LKDYDTALKL LEEFRQTQQV PPNKIAYEYS ELLLYQNQVM
210 220 230 240 250
REANLFQESL EHIETYEKLI CDKLLVEEIK GEMLLKLGRL KEASEVFRNL
260 270 280 290 300
IDWNAENWCY YEGLEKALQL RSLDERLQLY EEVSKQHPRA VSPRRLPLSF
310 320 330 340 350
APGKKFRELM DKFLRPNFSK GCPPLFTTLK SLYCDTEKVS IIQELVTNYE
360 370 380 390 400
ASLKMNGYFS PYENGEKEPP TTLIWVQYFL AQHYDKLGQY FLALEYINAV
410 420 430 440 450
IASTPTLIEL FYMKAKIYKH MGNLKEAAQW MDEAQSLDTA DRFINSKCAK
460 470 480 490 500
YMLRANMIKE AEEMCSRFTR EGTSAMENLN EMQCMWFETE CISAYQRLGR
510 520 530 540 550
YGDALKKCHE VERHFLEITD DQFDFHTYCM RKMTLRAYVG LLRLEDALRR
560 570 580 590 600
HTFYFKAARS AIEIYLKLHD NPLTNDSKQQ DIDSENLSAK EMKKMLSKQR
610 620 630 640 650
RAQKKAKVEE ERKHTERERQ QKNQKKKREE EEEVTSGHKE ELIPEKLERV
660 670 680 690 700
DNPLEEAIKF LTPLKTLAAE SIDTHLLAFE IYFRKGKFLL MLQSVKRAFA
710 720 730 740 750
IESNNPWLHE CLIKFSKSVS NHSNLPDIVS KVLAQEMKKI FVNKDLHSFN
760 770 780 790 800
EDFLRHNATS LQHLLAGAKM MYFLDKSRQE KAIATATRLD ETIKNKNVKT
810 820 830 840 850
LIKVSEALLD GSFGNCSSQY EEYRKTCHSL LPLTPAFLPA AREALGLSAE
860
LNHTADHKLL MNEI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PZ53 | E9PZ53_MOUSE | N-alpha-acetyltransferase 16, NatA ... | Naa16 | 496 | Annotation score: | ||
E9Q3U5 | E9Q3U5_MOUSE | N-alpha-acetyltransferase 16, NatA ... | Naa16 | 76 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005056 mRNA Translation: BAB23782.1 AK152498 mRNA Translation: BAE31267.1 BC052445 mRNA Translation: AAH52445.1 |
CCDSi | CCDS27296.1 |
RefSeqi | NP_080108.1, NM_025832.2 |
Genome annotation databases
Ensembli | ENSMUST00000022597; ENSMUSP00000022597; ENSMUSG00000022020 |
GeneIDi | 66897 |
KEGGi | mmu:66897 |
UCSCi | uc007usv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005056 mRNA Translation: BAB23782.1 AK152498 mRNA Translation: BAE31267.1 BC052445 mRNA Translation: AAH52445.1 |
CCDSi | CCDS27296.1 |
RefSeqi | NP_080108.1, NM_025832.2 |
3D structure databases
SMRi | Q9DBB4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022597 |
PTM databases
iPTMneti | Q9DBB4 |
PhosphoSitePlusi | Q9DBB4 |
Proteomic databases
EPDi | Q9DBB4 |
MaxQBi | Q9DBB4 |
PaxDbi | Q9DBB4 |
PeptideAtlasi | Q9DBB4 |
PRIDEi | Q9DBB4 |
Protocols and materials databases
Antibodypediai | 23410, 59 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022597; ENSMUSP00000022597; ENSMUSG00000022020 |
GeneIDi | 66897 |
KEGGi | mmu:66897 |
UCSCi | uc007usv.1, mouse |
Organism-specific databases
CTDi | 79612 |
MGIi | MGI:1914147, Naa16 |
Phylogenomic databases
eggNOGi | KOG1156, Eukaryota |
GeneTreei | ENSGT00950000183174 |
HOGENOMi | CLU_006686_0_0_1 |
InParanoidi | Q9DBB4 |
OMAi | VNHTAIN |
OrthoDBi | 792708at2759 |
PhylomeDBi | Q9DBB4 |
TreeFami | TF106301 |
Enzyme and pathway databases
BRENDAi | 2.3.1.88, 3474 |
Miscellaneous databases
BioGRID-ORCSi | 66897, 0 hits in 17 CRISPR screens |
ChiTaRSi | Naa16, mouse |
PROi | PR:Q9DBB4 |
RNActi | Q9DBB4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022020, Expressed in embryo and 251 other tissues |
ExpressionAtlasi | Q9DBB4, baseline and differential |
Genevisiblei | Q9DBB4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR021183, NatA_aux_su IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12569, NARP1, 1 hit PF07719, TPR_2, 1 hit |
PIRSFi | PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAA16_MOUSE | |
Accessioni | Q9DBB4Primary (citable) accession number: Q9DBB4 Secondary accession number(s): Q3U7V2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot