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Protein

Neuroguidin

Gene

Ngdn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner.1 Publication

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroguidin
Alternative name(s):
EIF4E-binding protein
Gene namesi
Name:Ngdn
Synonyms:Ngd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1916216 Ngdn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001143322 – 315NeuroguidinAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei214PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DB96
MaxQBiQ9DB96
PaxDbiQ9DB96
PeptideAtlasiQ9DB96
PRIDEiQ9DB96

PTM databases

iPTMnetiQ9DB96
PhosphoSitePlusiQ9DB96

Expressioni

Tissue specificityi

Expressed in testis, ovary, spleen, kidney, hippocampus and cerebellum (at protein level). Expressed in testis, ovary, spleen, kidney, brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000022204 Expressed in 289 organ(s), highest expression level in vestibular organ
CleanExiMM_NGDN
GenevisibleiQ9DB96 MM

Interactioni

Subunit structurei

Interacts with CPEB1 and EIF4E.1 Publication

Protein-protein interaction databases

IntActiQ9DB96, 1 interactor
MINTiQ9DB96
STRINGi10090.ENSMUSP00000022815

Structurei

3D structure databases

ProteinModelPortaliQ9DB96
SMRiQ9DB96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 174Necessary for interaction with EIF4E1 PublicationAdd BLAST134

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 41Sequence analysisAdd BLAST35
Coiled coili181 – 203Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the SAS10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3117 Eukaryota
ENOG4111F0Z LUCA
GeneTreeiENSGT00500000044922
HOGENOMiHOG000013129
HOVERGENiHBG082025
InParanoidiQ9DB96
KOiK14765
OMAiFYLQDLT
OrthoDBiEOG091G0I9S
PhylomeDBiQ9DB96
TreeFamiTF313713

Family and domain databases

InterProiView protein in InterPro
IPR007146 Sas10/Utp3/C1D
PfamiView protein in Pfam
PF04000 Sas10_Utp3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DB96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPEVLESD VSSSITLLKN LQEQVMAVTA QIQALTTKVR AGTYSTEKGL
60 70 80 90 100
SFLEVKDQLL LMYLMDLSHL ILDKASGASL QGHPAVLRLV EIRTVLEKLR
110 120 130 140 150
PLDQKLKYQI DKLVKTAVTG SLSENDPLRF KPHPSNMVSK LSSEDEEESE
160 170 180 190 200
AEEGQSEASG KKSAKGSAKK YVPPRLVPVH YDETEAEREQ KRLEKAKRRA
210 220 230 240 250
LSSSVIRELK EQYSDAPEEI RDARHPHVTR QSQEDQHRVN YEESMMVRLS
260 270 280 290 300
VSKREKGLRR RASAMSSQLH SLTHFSDISA LTGGTAHLDE DQNPVKKRKK
310
LPKKGRKKKG FRRRW
Length:315
Mass (Da):35,659
Last modified:June 1, 2001 - v1
Checksum:iA5C59A3949A0F40C
GO

Sequence cautioni

The sequence AAH23770 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154G → D in AAH23770 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005098 mRNA Translation: BAB23816.1
BC023770 mRNA Translation: AAH23770.1 Different initiation.
BC052790 mRNA Translation: AAH52790.1
CCDSiCCDS36928.1
RefSeqiNP_081166.1, NM_026890.2
UniGeneiMm.21214

Genome annotation databases

EnsembliENSMUST00000022815; ENSMUSP00000022815; ENSMUSG00000022204
GeneIDi68966
KEGGimmu:68966
UCSCiuc007txx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005098 mRNA Translation: BAB23816.1
BC023770 mRNA Translation: AAH23770.1 Different initiation.
BC052790 mRNA Translation: AAH52790.1
CCDSiCCDS36928.1
RefSeqiNP_081166.1, NM_026890.2
UniGeneiMm.21214

3D structure databases

ProteinModelPortaliQ9DB96
SMRiQ9DB96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DB96, 1 interactor
MINTiQ9DB96
STRINGi10090.ENSMUSP00000022815

PTM databases

iPTMnetiQ9DB96
PhosphoSitePlusiQ9DB96

Proteomic databases

EPDiQ9DB96
MaxQBiQ9DB96
PaxDbiQ9DB96
PeptideAtlasiQ9DB96
PRIDEiQ9DB96

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022815; ENSMUSP00000022815; ENSMUSG00000022204
GeneIDi68966
KEGGimmu:68966
UCSCiuc007txx.2 mouse

Organism-specific databases

CTDi25983
MGIiMGI:1916216 Ngdn

Phylogenomic databases

eggNOGiKOG3117 Eukaryota
ENOG4111F0Z LUCA
GeneTreeiENSGT00500000044922
HOGENOMiHOG000013129
HOVERGENiHBG082025
InParanoidiQ9DB96
KOiK14765
OMAiFYLQDLT
OrthoDBiEOG091G0I9S
PhylomeDBiQ9DB96
TreeFamiTF313713

Miscellaneous databases

PROiPR:Q9DB96
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022204 Expressed in 289 organ(s), highest expression level in vestibular organ
CleanExiMM_NGDN
GenevisibleiQ9DB96 MM

Family and domain databases

InterProiView protein in InterPro
IPR007146 Sas10/Utp3/C1D
PfamiView protein in Pfam
PF04000 Sas10_Utp3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNGDN_MOUSE
AccessioniPrimary (citable) accession number: Q9DB96
Secondary accession number(s): Q8CIJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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