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Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

Uqcrc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (By similarity).By similarity

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Protein family/group databases

MEROPSiM16.974

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene namesi
Name:Uqcrc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914253 Uqcrc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionBy similarityAdd BLAST14
ChainiPRO_000002679215 – 453Cytochrome b-c1 complex subunit 2, mitochondrialAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66N6-acetyllysineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei250N6-acetyllysineCombined sources1
Modified residuei368PhosphoserineBy similarity1

Post-translational modificationi

Acetylation of Lys-159 and Lys-250 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DB77
MaxQBiQ9DB77
PaxDbiQ9DB77
PeptideAtlasiQ9DB77
PRIDEiQ9DB77
TopDownProteomicsiQ9DB77

PTM databases

iPTMnetiQ9DB77
PhosphoSitePlusiQ9DB77
SwissPalmiQ9DB77

Expressioni

Gene expression databases

BgeeiENSMUSG00000030884 Expressed in 299 organ(s), highest expression level in aorta
CleanExiMM_UQCRC2
ExpressionAtlasiQ9DB77 baseline and differential
GenevisibleiQ9DB77 MM

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

BioGridi211868, 4 interactors
ComplexPortaliCPX-563 Mitochondrial respiratory chain complex III
CORUMiQ9DB77
IntActiQ9DB77, 17 interactors
MINTiQ9DB77
STRINGi10090.ENSMUSP00000033176

Structurei

3D structure databases

ProteinModelPortaliQ9DB77
SMRiQ9DB77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2583 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074666
HOGENOMiHOG000046923
HOVERGENiHBG055236
InParanoidiQ9DB77
KOiK00415
OMAiVECLRDD
OrthoDBiEOG091G0A7X
PhylomeDBiQ9DB77
TreeFamiTF105033

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 3 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9DB77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLSRAGSF SRFYSLKVAP KVKTSAAPGG VPLQPQDLEF TKLPNGLVIA
60 70 80 90 100
SLENYAPLSR IGLFVKAGSR YEDSNNLGTS HLLRLASSLT TKGASSFKIT
110 120 130 140 150
RGIEAVGGKL SVTATRENMA YTVEGIRSDI EILMEFLLNV TTAPEFRRWE
160 170 180 190 200
VAALRSQLKI DKAVAFQNSQ TRIIENLHDV AYKNALANPL YCPDYRMGKI
210 220 230 240 250
TSEELHYFVQ NHFTSARMAL VGLGVSHSVL KQVAEQFLNM RGGLGLAGAK
260 270 280 290 300
AKYRGGEIRE QNGDNLVHAA IVAESAAIGN AEANAFSVLQ HLLGAGPHIK
310 320 330 340 350
RGNNTTSLLS QSVAKGSHQP FDVSAFNASY SDSGLFGIYT ISQAAAAGEV
360 370 380 390 400
INAAYNQVKA VAQGNLSSAD VQAAKNKLKA GYLMSVETSE GFLSEIGSQA
410 420 430 440 450
LAAGSYMPPS TVLQQIDSVA DADVVKAAKK FVSGKKSMAA SGNLGHTPFL

DEL
Length:453
Mass (Da):48,235
Last modified:June 1, 2001 - v1
Checksum:i24A2BDDDA657867E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LI98A0A140LI98_MOUSE
Cytochrome b-c1 complex subunit 2, ...
Uqcrc2
145Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36Q → L in BAB25176 (PubMed:16141072).Curated1
Sequence conflicti319Q → R in BAC36876 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005151 mRNA Translation: BAB23845.1
AK007669 mRNA Translation: BAB25176.1
AK077583 mRNA Translation: BAC36876.1
AK088103 mRNA Translation: BAC40146.1
BC003423 mRNA Translation: AAH03423.1
CCDSiCCDS21795.1
PIRiPC7073
RefSeqiNP_080175.1, NM_025899.2
UniGeneiMm.334206

Genome annotation databases

EnsembliENSMUST00000033176; ENSMUSP00000033176; ENSMUSG00000030884
GeneIDi67003
KEGGimmu:67003
UCSCiuc009jms.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005151 mRNA Translation: BAB23845.1
AK007669 mRNA Translation: BAB25176.1
AK077583 mRNA Translation: BAC36876.1
AK088103 mRNA Translation: BAC40146.1
BC003423 mRNA Translation: AAH03423.1
CCDSiCCDS21795.1
PIRiPC7073
RefSeqiNP_080175.1, NM_025899.2
UniGeneiMm.334206

3D structure databases

ProteinModelPortaliQ9DB77
SMRiQ9DB77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211868, 4 interactors
ComplexPortaliCPX-563 Mitochondrial respiratory chain complex III
CORUMiQ9DB77
IntActiQ9DB77, 17 interactors
MINTiQ9DB77
STRINGi10090.ENSMUSP00000033176

Protein family/group databases

MEROPSiM16.974

PTM databases

iPTMnetiQ9DB77
PhosphoSitePlusiQ9DB77
SwissPalmiQ9DB77

Proteomic databases

EPDiQ9DB77
MaxQBiQ9DB77
PaxDbiQ9DB77
PeptideAtlasiQ9DB77
PRIDEiQ9DB77
TopDownProteomicsiQ9DB77

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033176; ENSMUSP00000033176; ENSMUSG00000030884
GeneIDi67003
KEGGimmu:67003
UCSCiuc009jms.1 mouse

Organism-specific databases

CTDi7385
MGIiMGI:1914253 Uqcrc2

Phylogenomic databases

eggNOGiKOG2583 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074666
HOGENOMiHOG000046923
HOVERGENiHBG055236
InParanoidiQ9DB77
KOiK00415
OMAiVECLRDD
OrthoDBiEOG091G0A7X
PhylomeDBiQ9DB77
TreeFamiTF105033

Miscellaneous databases

ChiTaRSiUqcrc2 mouse
PROiPR:Q9DB77
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030884 Expressed in 299 organ(s), highest expression level in aorta
CleanExiMM_UQCRC2
ExpressionAtlasiQ9DB77 baseline and differential
GenevisibleiQ9DB77 MM

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 3 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQCR2_MOUSE
AccessioniPrimary (citable) accession number: Q9DB77
Secondary accession number(s): Q8BK11, Q9CVK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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