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UniProtKB - Q9DB38 (ZN580_MOUSE)
Protein
Zinc finger protein 580
Gene
Znf580
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O2-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 92 – 114 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 120 – 142 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 150 – 172 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cellular response to hydrogen peroxide Source: UniProtKB
- chemotaxis Source: UniProtKB-KW
- inflammatory response Source: UniProtKB-KW
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of leukocyte chemotaxis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Chemotaxis, Inflammatory response, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 580 |
Gene namesi | Name:Znf580 Synonyms:Zfp580 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916242, Zfp580 |
VEuPathDBi | HostDB:ENSMUSG00000055633 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Note: Colocalized with SMAD2 in the nucleus.By similarity
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047672 | 1 – 172 | Zinc finger protein 580Add BLAST | 172 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 31 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q9DB38 |
PaxDbi | Q9DB38 |
PRIDEi | Q9DB38 |
PTM databases
iPTMneti | Q9DB38 |
PhosphoSitePlusi | Q9DB38 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000055633, Expressed in primary visual cortex and 129 other tissues |
Genevisiblei | Q9DB38, MM |
Interactioni
Subunit structurei
Interacts with SMAD2.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000065861 |
Miscellaneous databases
RNActi | Q9DB38, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 92 | DisorderedSequence analysisAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 31 | Pro residuesSequence analysisAdd BLAST | 31 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 92 – 114 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 120 – 142 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 150 – 172 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163086 |
HOGENOMi | CLU_002678_42_5_1 |
InParanoidi | Q9DB38 |
OMAi | VPYMYTV |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9DB38 |
TreeFami | TF338348 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9DB38-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLPPRPPH PRSSSPEVMD PPPPKTPPFP KAEGPSSTSS SVAGPRPPRL
60 70 80 90 100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE ATPGEPGPRK GYSCPECARV
110 120 130 140 150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH
160 170
TCPLCPRRFQ DAAELAQHVR LH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A140LJI2 | A0A140LJI2_MOUSE | Zinc finger protein 580 | Zfp580 | 230 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005257 mRNA Translation: BAB23910.1 BC066001 mRNA Translation: AAH66001.1 |
CCDSi | CCDS51982.1 |
RefSeqi | NP_081176.1, NM_026900.1 |
Genome annotation databases
Ensembli | ENSMUST00000069324; ENSMUSP00000065861; ENSMUSG00000055633 |
GeneIDi | 68992 |
KEGGi | mmu:68992 |
UCSCi | uc009ezp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005257 mRNA Translation: BAB23910.1 BC066001 mRNA Translation: AAH66001.1 |
CCDSi | CCDS51982.1 |
RefSeqi | NP_081176.1, NM_026900.1 |
3D structure databases
SMRi | Q9DB38 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000065861 |
PTM databases
iPTMneti | Q9DB38 |
PhosphoSitePlusi | Q9DB38 |
Proteomic databases
MaxQBi | Q9DB38 |
PaxDbi | Q9DB38 |
PRIDEi | Q9DB38 |
Protocols and materials databases
Antibodypediai | 19580, 87 antibodies from 15 providers |
Genome annotation databases
Ensembli | ENSMUST00000069324; ENSMUSP00000065861; ENSMUSG00000055633 |
GeneIDi | 68992 |
KEGGi | mmu:68992 |
UCSCi | uc009ezp.2, mouse |
Organism-specific databases
CTDi | 68992 |
MGIi | MGI:1916242, Zfp580 |
VEuPathDBi | HostDB:ENSMUSG00000055633 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163086 |
HOGENOMi | CLU_002678_42_5_1 |
InParanoidi | Q9DB38 |
OMAi | VPYMYTV |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9DB38 |
TreeFami | TF338348 |
Miscellaneous databases
BioGRID-ORCSi | 68992, 0 hits in 64 CRISPR screens |
PROi | PR:Q9DB38 |
RNActi | Q9DB38, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055633, Expressed in primary visual cortex and 129 other tissues |
Genevisiblei | Q9DB38, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN580_MOUSE | |
Accessioni | Q9DB38Primary (citable) accession number: Q9DB38 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot