Znf580

Functionⁱ

Involved in the regulation of endothelial cell proliferation and migration. Mediates H₂O₂-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	92 – 114	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	120 – 142	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	150 – 172	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hydrogen peroxide Source: UniProtKB
chemotaxis Source: UniProtKB-KW
inflammatory response Source: UniProtKB-KW
positive regulation of endothelial cell migration Source: UniProtKB
positive regulation of endothelial cell proliferation Source: UniProtKB
positive regulation of gene expression Source: UniProtKB
positive regulation of interleukin-8 production Source: UniProtKB
positive regulation of leukocyte chemotaxis Source: UniProtKB
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Chemotaxis, Inflammatory response, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 580
Gene namesⁱ	Name:Znf580 Synonyms:Zfp580
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1916242 Zfp580

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047672	1 – 172	Zinc finger protein 580Add BLAST		172

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	31	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	118	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9DB38
PaxDbⁱ	Q9DB38
PRIDEⁱ	Q9DB38

PTM databases

iPTMnetⁱ	Q9DB38
PhosphoSitePlusⁱ	Q9DB38

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000055633 Expressed in 84 organ(s), highest expression level in embryo
CleanExⁱ	MM_ZFP580
ExpressionAtlasⁱ	Q9DB38 baseline and differential
Genevisibleⁱ	Q9DB38 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SMAD2.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000065861

STRINGⁱ

10090.ENSMUSP00000065861

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9DB38
SMRⁱ	Q9DB38
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	5 – 88	Pro-richAdd BLAST		84

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	92 – 114	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	120 – 142	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	150 – 172	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149029
HOGENOMⁱ	HOG000059663
HOVERGENⁱ	HBG079385
InParanoidⁱ	Q9DB38
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0STS
PhylomeDBⁱ	Q9DB38
TreeFamⁱ	TF338348

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9DB38-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLLPPRPPH PRSSSPEVMD PPPPKTPPFP KAEGPSSTSS SVAGPRPPRL 
        60         70         80         90        100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE ATPGEPGPRK GYSCPECARV 
       110        120        130        140        150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH 
       160        170 
TCPLCPRRFQ DAAELAQHVR LH

Length:172

Mass (Da):18,837

Last modified:June 1, 2001 - v1

Checksum:ⁱ885238D4EB35CCAE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A140LJI2	A0A140LJI2_MOUSE		Zinc finger protein 580 Zinc finger protein 580	Zfp580	230	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK005257 mRNA Translation: BAB23910.1 BC066001 mRNA Translation: AAH66001.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS51982.1
NCBI Reference Sequences More...RefSeqⁱ	NP_081176.1, NM_026900.1
UniGeneⁱ	Mm.41484

Genome annotation databases

Ensemblⁱ	ENSMUST00000069324; ENSMUSP00000065861; ENSMUSG00000055633
GeneIDⁱ	68992
KEGGⁱ	mmu:68992
UCSC genome browser More...UCSCⁱ	uc009ezp.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9DB38	Zinc finger protein 580		MOUSE		230	UniRef100_Q9DB38
Zinc finger protein 580		RAT		172
UPI000A317DA8		MUSCR		206

Protein	Similar proteins		Species	Score	Length	Source
Q9DB38	Zinc finger protein 580		MOUSE		230	UniRef90_Q9DB38
Zinc finger protein 580		RAT		172
UPI000A317DA8		MUSCR		206
UPI000A313AE4		MUSPA		206

Protein	Similar proteins		Species	Score	Length	Source
Q9DB38	Zinc finger protein 580		MOUSE		230	UniRef50_Q9DB38
Zinc finger protein 580		RAT		172
Uncharacterized protein		CAVPO		211
Uncharacterized protein		OTOGA		172
Uncharacterized protein		RHIRO		172
+64

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK005257 mRNA Translation: BAB23910.1 BC066001 mRNA Translation: AAH66001.1
CCDSⁱ	CCDS51982.1
RefSeqⁱ	NP_081176.1, NM_026900.1
UniGeneⁱ	Mm.41484

3D structure databases

ProteinModelPortalⁱ	Q9DB38
SMRⁱ	Q9DB38
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000065861

STRINGⁱ

10090.ENSMUSP00000065861

PTM databases

iPTMnetⁱ	Q9DB38
PhosphoSitePlusⁱ	Q9DB38

Proteomic databases

MaxQBⁱ	Q9DB38
PaxDbⁱ	Q9DB38
PRIDEⁱ	Q9DB38

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000069324; ENSMUSP00000065861; ENSMUSG00000055633
GeneIDⁱ	68992
KEGGⁱ	mmu:68992
UCSCⁱ	uc009ezp.2 mouse

Organism-specific databases

CTDⁱ	68992
MGIⁱ	MGI:1916242 Zfp580

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000149029
HOGENOMⁱ	HOG000059663
HOVERGENⁱ	HBG079385
InParanoidⁱ	Q9DB38
OrthoDBⁱ	EOG091G0STS
PhylomeDBⁱ	Q9DB38
TreeFamⁱ	TF338348

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9DB38
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000055633 Expressed in 84 organ(s), highest expression level in embryo
CleanExⁱ	MM_ZFP580
ExpressionAtlasⁱ	Q9DB38 baseline and differential
Genevisibleⁱ	Q9DB38 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN580_MOUSE
Accessionⁱ	Q9DB38Primary (citable) accession number: Q9DB38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	June 1, 2001
	Last modified:	October 10, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9DB38 (ZN580_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger protein 580

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ