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Protein

Zinc finger protein 580

Gene

Znf580

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O2-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processChemotaxis, Inflammatory response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 580
Gene namesi
Name:Znf580
Synonyms:Zfp580
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916242 Zfp580

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476721 – 172Zinc finger protein 580Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9DB38
PaxDbiQ9DB38
PRIDEiQ9DB38

PTM databases

iPTMnetiQ9DB38
PhosphoSitePlusiQ9DB38

Expressioni

Gene expression databases

BgeeiENSMUSG00000055633 Expressed in 84 organ(s), highest expression level in embryo
CleanExiMM_ZFP580
ExpressionAtlasiQ9DB38 baseline and differential
GenevisibleiQ9DB38 MM

Interactioni

Subunit structurei

Interacts with SMAD2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065861

Structurei

3D structure databases

ProteinModelPortaliQ9DB38
SMRiQ9DB38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 88Pro-richAdd BLAST84

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149029
HOGENOMiHOG000059663
HOVERGENiHBG079385
InParanoidiQ9DB38
OrthoDBiEOG091G0STS
PhylomeDBiQ9DB38
TreeFamiTF338348

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9DB38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLPPRPPH PRSSSPEVMD PPPPKTPPFP KAEGPSSTSS SVAGPRPPRL
60 70 80 90 100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE ATPGEPGPRK GYSCPECARV
110 120 130 140 150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH
160 170
TCPLCPRRFQ DAAELAQHVR LH
Length:172
Mass (Da):18,837
Last modified:June 1, 2001 - v1
Checksum:i885238D4EB35CCAE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LJI2A0A140LJI2_MOUSE
Zinc finger protein 580
Zfp580
230Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005257 mRNA Translation: BAB23910.1
BC066001 mRNA Translation: AAH66001.1
CCDSiCCDS51982.1
RefSeqiNP_081176.1, NM_026900.1
UniGeneiMm.41484

Genome annotation databases

EnsembliENSMUST00000069324; ENSMUSP00000065861; ENSMUSG00000055633
GeneIDi68992
KEGGimmu:68992
UCSCiuc009ezp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005257 mRNA Translation: BAB23910.1
BC066001 mRNA Translation: AAH66001.1
CCDSiCCDS51982.1
RefSeqiNP_081176.1, NM_026900.1
UniGeneiMm.41484

3D structure databases

ProteinModelPortaliQ9DB38
SMRiQ9DB38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065861

PTM databases

iPTMnetiQ9DB38
PhosphoSitePlusiQ9DB38

Proteomic databases

MaxQBiQ9DB38
PaxDbiQ9DB38
PRIDEiQ9DB38

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069324; ENSMUSP00000065861; ENSMUSG00000055633
GeneIDi68992
KEGGimmu:68992
UCSCiuc009ezp.2 mouse

Organism-specific databases

CTDi68992
MGIiMGI:1916242 Zfp580

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149029
HOGENOMiHOG000059663
HOVERGENiHBG079385
InParanoidiQ9DB38
OrthoDBiEOG091G0STS
PhylomeDBiQ9DB38
TreeFamiTF338348

Miscellaneous databases

PROiPR:Q9DB38
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055633 Expressed in 84 organ(s), highest expression level in embryo
CleanExiMM_ZFP580
ExpressionAtlasiQ9DB38 baseline and differential
GenevisibleiQ9DB38 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN580_MOUSE
AccessioniPrimary (citable) accession number: Q9DB38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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