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Protein

ATP synthase subunit O, mitochondrial

Gene

Atp5o

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit O, mitochondrial
Alternative name(s):
Oligomycin sensitivity conferral protein
Short name:
OSCP
Gene namesi
Name:Atp5o
Synonyms:D12Wsu28e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:106341 Atp5o

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionBy similarityAdd BLAST23
ChainiPRO_000000264724 – 213ATP synthase subunit O, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei73N6-acetyllysineCombined sources1
Modified residuei90N6-succinyllysineCombined sources1
Modified residuei100N6-acetyllysine; alternateCombined sources1
Modified residuei100N6-succinyllysine; alternateCombined sources1
Modified residuei158N6-acetyllysine; alternateCombined sources1
Modified residuei158N6-succinyllysine; alternateCombined sources1
Modified residuei162N6-acetyllysine; alternateCombined sources1
Modified residuei162N6-succinyllysine; alternateCombined sources1
Modified residuei172N6-acetyllysineCombined sources1
Modified residuei176N6-acetyllysineCombined sources1
Modified residuei192N6-acetyllysineBy similarity1
Modified residuei199N6-succinyllysineCombined sources1

Post-translational modificationi

Acetylation of Lys-70 and Lys-158 is observed in liver mitochondria from fasted mice but not from fed mice.
Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3 (By similarity).By similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DB20
MaxQBiQ9DB20
PaxDbiQ9DB20
PeptideAtlasiQ9DB20
PRIDEiQ9DB20
TopDownProteomicsiQ9DB20

PTM databases

iPTMnetiQ9DB20
PhosphoSitePlusiQ9DB20
SwissPalmiQ9DB20

Expressioni

Gene expression databases

BgeeiENSMUSG00000022956
ExpressionAtlasiQ9DB20 baseline and differential
GenevisibleiQ9DB20 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205752, 5 interactors
IntActiQ9DB20, 7 interactors
MINTiQ9DB20
STRINGi10090.ENSMUSP00000023677

Structurei

3D structure databases

ProteinModelPortaliQ9DB20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase delta chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1662 Eukaryota
COG0712 LUCA
GeneTreeiENSGT00390000015060
HOGENOMiHOG000075825
HOVERGENiHBG004309
InParanoidiQ9DB20
KOiK02137
OMAiMVDNIQD
OrthoDBiEOG091G0L4M
PhylomeDBiQ9DB20
TreeFamiTF106241

Family and domain databases

Gene3Di1.10.520.20, 1 hit
HAMAPiMF_01416 ATP_synth_delta_bact, 1 hit
InterProiView protein in InterPro
IPR026015 ATP_synth_OSCP/delta_N_sf
IPR020781 ATPase_OSCP/d_CS
IPR000711 ATPase_OSCP/dsu
PANTHERiPTHR11910 PTHR11910, 1 hit
PfamiView protein in Pfam
PF00213 OSCP, 1 hit
PRINTSiPR00125 ATPASEDELTA
SUPFAMiSSF47928 SSF47928, 1 hit
TIGRFAMsiTIGR01145 ATP_synt_delta, 1 hit
PROSITEiView protein in PROSITE
PS00389 ATPASE_DELTA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DB20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAASGLS RQVRSFSTSV VRPFAKLVRP PVQVYGIEGR YATALYSAAS
60 70 80 90 100
KEKKLDQVEK ELLRVGQLLK DPKVSLAVLN PYIKRTVKVK SLNDITKREK
110 120 130 140 150
FSPLTANLMN LLAENGRLGN TQGIISAFST IMSVHRGEVP CTVTTASPLD
160 170 180 190 200
DAVLSELKTV LKSFLSPNQI LKLEIKTDPS IMGGMIVRIG EKYVDMSAKS
210
KIQKLSKAMR EML
Length:213
Mass (Da):23,364
Last modified:June 1, 2001 - v1
Checksum:i1B0DAD4CCFCCB086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005309 mRNA Translation: BAB23945.1
BC012241 mRNA Translation: AAH12241.1
CCDSiCCDS28331.1
RefSeqiNP_613063.1, NM_138597.2
UniGeneiMm.41

Genome annotation databases

EnsembliENSMUST00000023677; ENSMUSP00000023677; ENSMUSG00000022956
GeneIDi28080
KEGGimmu:28080
UCSCiuc007zys.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATPO_MOUSE
AccessioniPrimary (citable) accession number: Q9DB20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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