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Protein

39S ribosomal protein L12, mitochondrial

Gene

Mrpl12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L12, mitochondrial
Short name:
L12mt
Short name:
MRP-L12
Gene namesi
Name:Mrpl12
Synonyms:Rpml12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926273 Mrpl12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
ChainiPRO_000003045947 – 20139S ribosomal protein L12, mitochondrialAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141N6-acetyllysineCombined sources1
Modified residuei153N6-succinyllysineCombined sources1
Modified residuei165N6-succinyllysineCombined sources1
Modified residuei181N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DB15
MaxQBiQ9DB15
PaxDbiQ9DB15
PeptideAtlasiQ9DB15
PRIDEiQ9DB15

PTM databases

iPTMnetiQ9DB15
PhosphoSitePlusiQ9DB15

Expressioni

Gene expression databases

BgeeiENSMUSG00000039640 Expressed in 285 organ(s), highest expression level in outflow tract
CleanExiMM_MRPL12
GenevisibleiQ9DB15 MM

Interactioni

Subunit structurei

Interacts with NOA1.By similarity

Protein-protein interaction databases

BioGridi207875, 1 interactor
IntActiQ9DB15, 5 interactors
MINTiQ9DB15
STRINGi10090.ENSMUSP00000044417

Structurei

3D structure databases

ProteinModelPortaliQ9DB15
SMRiQ9DB15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1715 Eukaryota
COG0222 LUCA
GeneTreeiENSGT00390000000190
HOGENOMiHOG000248814
HOVERGENiHBG001832
InParanoidiQ9DB15
KOiK02935
OMAiVDNAPKP
OrthoDBiEOG091G0BQ7
PhylomeDBiQ9DB15
TreeFamiTF105997

Family and domain databases

CDDicd00387 Ribosomal_L7_L12, 1 hit
Gene3Di3.30.1390.10, 1 hit
HAMAPiMF_00368 Ribosomal_L7_L12, 1 hit
InterProiView protein in InterPro
IPR000206 Ribosomal_L7/12
IPR014719 Ribosomal_L7/12_C/ClpS-like
IPR013823 Ribosomal_L7/L12_C
IPR008932 Ribosomal_L7/L12_oligo
IPR036235 Ribosomal_L7/L12_oligo_N_sf
PfamiView protein in Pfam
PF00542 Ribosomal_L12, 1 hit
PF16320 Ribosomal_L12_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001326 Ribosomal_L7/L12_C, 1 hit
SUPFAMiSSF48300 SSF48300, 1 hit
SSF54736 SSF54736, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DB15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPVAASRCL WGPRLGLRGA ALRLARQQMP SVCAARQLRS SSHRRSEALA
60 70 80 90 100
GAPLDNAPKE YPPKIQQLVQ DIASLTLLEI SDLNELLKKT LKIQDVGLMP
110 120 130 140 150
MGGMVPGPVS AAAPASEAAE EEDVPKQKER THFTVRLTEA KPVDKVKLIK
160 170 180 190 200
EIKNYVQGIN LVQAKKLVES LPQEIKANVA KAEAEKIKAA LEAVGGTVVL

E
Length:201
Mass (Da):21,708
Last modified:December 13, 2001 - v2
Checksum:i893BEFB4F154076D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8 – 18RCLWGPRLGLR → AACGGHGLDSW in BAB23955 (PubMed:16141072).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005328 mRNA Translation: BAB23955.1
AK028168 mRNA Translation: BAC25787.1
AK134816 mRNA Translation: BAE22297.1
AK166969 mRNA Translation: BAE39152.1
AK168337 mRNA Translation: BAE40275.1
AL669855 Genomic DNA No translation available.
BC005712 mRNA Translation: AAH05712.1
BC019565 mRNA Translation: AAH19565.1
CCDSiCCDS25737.1
RefSeqiNP_081480.2, NM_027204.2
UniGeneiMm.133851
Mm.491127

Genome annotation databases

EnsembliENSMUST00000043627; ENSMUSP00000044417; ENSMUSG00000039640
GeneIDi56282
KEGGimmu:56282
UCSCiuc007mta.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005328 mRNA Translation: BAB23955.1
AK028168 mRNA Translation: BAC25787.1
AK134816 mRNA Translation: BAE22297.1
AK166969 mRNA Translation: BAE39152.1
AK168337 mRNA Translation: BAE40275.1
AL669855 Genomic DNA No translation available.
BC005712 mRNA Translation: AAH05712.1
BC019565 mRNA Translation: AAH19565.1
CCDSiCCDS25737.1
RefSeqiNP_081480.2, NM_027204.2
UniGeneiMm.133851
Mm.491127

3D structure databases

ProteinModelPortaliQ9DB15
SMRiQ9DB15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207875, 1 interactor
IntActiQ9DB15, 5 interactors
MINTiQ9DB15
STRINGi10090.ENSMUSP00000044417

PTM databases

iPTMnetiQ9DB15
PhosphoSitePlusiQ9DB15

Proteomic databases

EPDiQ9DB15
MaxQBiQ9DB15
PaxDbiQ9DB15
PeptideAtlasiQ9DB15
PRIDEiQ9DB15

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043627; ENSMUSP00000044417; ENSMUSG00000039640
GeneIDi56282
KEGGimmu:56282
UCSCiuc007mta.1 mouse

Organism-specific databases

CTDi6182
MGIiMGI:1926273 Mrpl12

Phylogenomic databases

eggNOGiKOG1715 Eukaryota
COG0222 LUCA
GeneTreeiENSGT00390000000190
HOGENOMiHOG000248814
HOVERGENiHBG001832
InParanoidiQ9DB15
KOiK02935
OMAiVDNAPKP
OrthoDBiEOG091G0BQ7
PhylomeDBiQ9DB15
TreeFamiTF105997

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:Q9DB15
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039640 Expressed in 285 organ(s), highest expression level in outflow tract
CleanExiMM_MRPL12
GenevisibleiQ9DB15 MM

Family and domain databases

CDDicd00387 Ribosomal_L7_L12, 1 hit
Gene3Di3.30.1390.10, 1 hit
HAMAPiMF_00368 Ribosomal_L7_L12, 1 hit
InterProiView protein in InterPro
IPR000206 Ribosomal_L7/12
IPR014719 Ribosomal_L7/12_C/ClpS-like
IPR013823 Ribosomal_L7/L12_C
IPR008932 Ribosomal_L7/L12_oligo
IPR036235 Ribosomal_L7/L12_oligo_N_sf
PfamiView protein in Pfam
PF00542 Ribosomal_L12, 1 hit
PF16320 Ribosomal_L12_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001326 Ribosomal_L7/L12_C, 1 hit
SUPFAMiSSF48300 SSF48300, 1 hit
SSF54736 SSF54736, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM12_MOUSE
AccessioniPrimary (citable) accession number: Q9DB15
Secondary accession number(s): B1ATZ3, Q3TKJ3, Q99JS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: December 13, 2001
Last modified: September 12, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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