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Protein

GON-4-like protein

Gene

Gon4l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1 (PubMed:21454521). Required for B cell lymphopoiesis (PubMed:20530203).2 Publications

GO - Molecular functioni

  • DNA binding Source: InterPro
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • B cell differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GON-4-like protein
Alternative name(s):
GON-4 homolog
Gene namesi
Name:Gon4l
Synonyms:Gon4, Kiaa1606
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917579 Gon4l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971101 – 2260GON-4-like proteinAdd BLAST2260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347PhosphoserineBy similarity1
Modified residuei784PhosphoserineCombined sources1
Modified residuei1925PhosphoserineBy similarity1
Modified residuei1998PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DB00
MaxQBiQ9DB00
PaxDbiQ9DB00
PRIDEiQ9DB00

PTM databases

iPTMnetiQ9DB00
PhosphoSitePlusiQ9DB00

Expressioni

Tissue specificityi

Expressed in thymus. Specifically expressed in B cells and their precursors (at protein level). Also detected in brain, heart, spleen and bone marrow.1 Publication

Interactioni

Subunit structurei

Found in a complex with YY1, SIN3A and HDAC1.1 Publication

Protein-protein interaction databases

BioGridi217912, 3 interactors
STRINGi10090.ENSMUSP00000080397

Structurei

Secondary structure

12260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9DB00
SMRiQ9DB00
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DB00

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1648 – 1720PAH 1PROSITE-ProRule annotationAdd BLAST73
Domaini1730 – 1801PAH 2PROSITE-ProRule annotationAdd BLAST72
Domaini2167 – 2220Myb-likePROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni610 – 1364Required for interaction with YY1, SIN3A AND HDAC1, and transcriptional repression activity1 PublicationAdd BLAST755

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 248Poly-Lys7
Compositional biasi380 – 385Poly-Glu6
Compositional biasi450 – 456Poly-Pro7
Compositional biasi519 – 578Asp-richAdd BLAST60
Compositional biasi622 – 625Poly-Glu4
Compositional biasi1476 – 1570Glu-richAdd BLAST95

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHDM Eukaryota
ENOG410XS4M LUCA
HOGENOMiHOG000082442
HOVERGENiHBG081563
InParanoidiQ9DB00

Family and domain databases

InterProiView protein in InterPro
IPR033277 GON-4-like
IPR009057 Homeobox-like_sf
IPR017877 Myb-like_dom
IPR003822 PAH
IPR036600 PAH_sf
PANTHERiPTHR16088:SF11 PTHR16088:SF11, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47762 SSF47762, 2 hits
PROSITEiView protein in PROSITE
PS50090 MYB_LIKE, 1 hit
PS51477 PAH, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9DB00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPCKKRRLS VTESSQQQDD QEGDDLDLEA AVKPDTDQLP DSASESLSWG
60 70 80 90 100
QSQDSAVCPE GLSMQDGDDQ LRAEGLSLNS KMLAQHVNLA VLEAVDVAVS
110 120 130 140 150
QEIPLPSLES SHSLPVHVDK GRLQVSASKK GKRVVFTPGQ VTREDRGDHP
160 170 180 190 200
VPEEPPSGEP AEEAKTEGGE LELRSDGEVP LLSSSSQSAK PGAQPRKSVQ
210 220 230 240 250
PDGSAFPQDK PLGPLVRQAE EEMEDGGLFI PTEEQDSEES DKKKKTKKGT
260 270 280 290 300
KRKRDGKGPE QGTMVYDPKL DDMLDRTLED GAKQHNLTAV NVRNILHEVI
310 320 330 340 350
TNEHVVAMMK AAISETEDMP LFEPKMTRSK LKEVVEKGVV IPTWNISPIK
360 370 380 390 400
KASEIKQPPQ FVDIHLEEDD SSDEEYSPDE EEEDETAEES LLESDVESTA
410 420 430 440 450
SSPRGVKRSR LRLSSEVAET DEESGMLSEV EKAATPALRH ISAEVVPMGP
460 470 480 490 500
PPPPKPKQSR DSVFMEKLDA VDEELASSPV CMDSFQPMED SLIAFRTRSK
510 520 530 540 550
MPLKDVPLGQ LEAELQAPDI TPDMYDPNTA DDEDWKQWLG GLINDDVENE
560 570 580 590 600
DEADDDDDPE YNFLEDLDEP DTEDFRTDRA VRITKKEVNG LMEELFETVQ
610 620 630 640 650
SVVPSKFQDE MGFSNMEDDG PEEEERATES RPSFNTPQAL RFEEPLANLL
660 670 680 690 700
NERHRTVKEL LEQLKMKKPS VRQQPEVEKL KPQEEAAHQT LVLDPAQRSR
710 720 730 740 750
LQQQMQQHVQ LLTQIYLLTT SNPNLSSEAS TTRIFLKELG TFAENSIALH
760 770 780 790 800
QQFNPRFQTL FQPCNWMGAM RLIEDFTQVS IDCSPHKTAK KTASEFPCLP
810 820 830 840 850
KQVAWILATN KVFMYPELLP ICSLKANNPR DKTIFTKAED NLLALGLKHF
860 870 880 890 900
EGTEFPKPLI SKYLVTCKTA HQLTVRIKNL NLNRAPNNVI KFYKKTKQLP
910 920 930 940 950
VLVRCCEEIQ PHQWKPPFEK EEHRLPFWLK ASLQSIQDEL RNISEGATEG
960 970 980 990 1000
GSVTTATESS TDQHLQKASP ALGDEPQYPL LLPKGVVLKL KPGSKRFSRK
1010 1020 1030 1040 1050
AWRQKRPLVQ KPLLIQPSPS VQPVFNPGKM ATWPTQSEVP PSNTVVQIPH
1060 1070 1080 1090 1100
LIQPAAVLQT LPGFPSVGVR GEDGFESPTA LPAMPCGSEA RTTFPLSETQ
1110 1120 1130 1140 1150
SAPPSCSAPK LMLPSLAPSK FRKPYVRRKP TRRKGAKVSP CVKPAPIIHP
1160 1170 1180 1190 1200
TPVIFTVPAT TVKVVSIGGG CNMIQPVSAA VAPSPQTIPI TTLLVNPTTF
1210 1220 1230 1240 1250
PCSLNQPLVA SSISPLIVSS NPLTLPVTSI PEDKAQVKLD VAEGKNAPQN
1260 1270 1280 1290 1300
PESKLKPQEL TPLCTTVFSK EEPKSWHSSA DTGSQEAFSE SSACSWAVVK
1310 1320 1330 1340 1350
TESQEGSSEK SACGWTVVKT EDGGHAVEPL PQNLQDSLSS SSKDLLNMVK
1360 1370 1380 1390 1400
MEAQDCMVEI SSNFPKQDIG EEVKEECSME LDSESPQEKP SSASEMSKQT
1410 1420 1430 1440 1450
VLQREDMQAA KSPSVPQDAA AEGRTSSHAS RGLPKSTLSS MGQGGGLSGP
1460 1470 1480 1490 1500
PGKLEDSANA DGQSVGTPAG PDTGGEKDGP EEEEEEDFDD LTQDEEDELS
1510 1520 1530 1540 1550
SASEESVLSV PELQETMEKL TWLASERRMS QEGESEEENS QEENSEPEEE
1560 1570 1580 1590 1600
EEEEAEGMET LQKEDEVNDE AVGDAAKKPP STLASPQTAP EIETSIAPAG
1610 1620 1630 1640 1650
ESIKAAGKGR SSHRARNKRG SRARASKDTS KLLLLYDEDI LDRDPLREQK
1660 1670 1680 1690 1700
DLAFAQAYLT RVREALQHTP GKYEDFLQII YEFESSTQMH SAVDLFKSLQ
1710 1720 1730 1740 1750
TLLQDWPQLL KDFAAFLLPE QALSCGLFEE QQAFEKSRKF LRQLEICFAE
1760 1770 1780 1790 1800
NPSHHQKIIK VLQGCADCLP QDIAELKTQM WQLLRGHDHL QDEFSIFFDH
1810 1820 1830 1840 1850
LRPAASRMGD FEEINWTEEK EYEFDGFEEV ILPDVEEDEE PAKVSTASKS
1860 1870 1880 1890 1900
KRRKEIGVQH QDKDTEWPEA AKDCSCSCHE GGPESKLKKS KRRNCHCSSK
1910 1920 1930 1940 1950
VCDSKPYKSK EPPELVGSGP LHEASTVPGS KEAGQGKDML EEEILEEQEN
1960 1970 1980 1990 2000
MEVTQSKTAR TTRKGEAPAP GSTIGSTLLC PAEVTPMELL LEGPALCSAE
2010 2020 2030 2040 2050
TPRLPPQTGA VVCSVRRNQA GPEVVSCLST SSLPPEEGED QRAAANSETI
2060 2070 2080 2090 2100
APHREASETE RLPETVEHSA PLPSPVSTRT RDTGRRHICG KAGSQSWLIE
2110 2120 2130 2140 2150
SRAEAEAAHV AAPICEKSSG ARASEAAPKT AREVLAEDSG TQGMGPEGAL
2160 2170 2180 2190 2200
PKASEATVCA NNSKVSSTGE KVVLWTREAD RVILTMCQEQ GAQPHTFSVI
2210 2220 2230 2240 2250
SQQLGNKTPV EVSHRFRELM QLFHTACEAS SEDEDDATST SNADQLSDHG
2260
DLLSEEELDE
Length:2,260
Mass (Da):248,742
Last modified:July 27, 2011 - v3
Checksum:iBB0F605666D642C6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K4DI71K4DI71_MOUSE
GON-4-like protein
Gon4l
2,243Annotation score:
E9Q507E9Q507_MOUSE
GON-4-like protein
Gon4l
2,242Annotation score:
A0A1D5RM47A0A1D5RM47_MOUSE
GON-4-like protein
Gon4l
502Annotation score:

Sequence cautioni

The sequence AAH16616 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB23992 differs from that shown. Chimeric cDNA.Curated
The sequence BAC65813 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti259P → L in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti734I → V in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1080A → S in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1341S → P in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1354Q → E in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1364F → L in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1392S → R in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1407M → T in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1438L → P in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti1458A → V in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti2069S → P in BAC65813 (PubMed:12693553).Curated1
Sequence conflicti2069S → P in AAH16616 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127377 Genomic DNA No translation available.
AK005385 mRNA Translation: BAB23992.1 Different termination.
AK122531 mRNA Translation: BAC65813.1 Different initiation.
BC016616 mRNA Translation: AAH16616.1 Different initiation.
RefSeqiXP_017175282.1, XM_017319793.1
UniGeneiMm.126870
Mm.482358

Genome annotation databases

GeneIDi76022
UCSCiuc008pxb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127377 Genomic DNA No translation available.
AK005385 mRNA Translation: BAB23992.1 Different termination.
AK122531 mRNA Translation: BAC65813.1 Different initiation.
BC016616 mRNA Translation: AAH16616.1 Different initiation.
RefSeqiXP_017175282.1, XM_017319793.1
UniGeneiMm.126870
Mm.482358

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG2NMR-A2148-2228[»]
ProteinModelPortaliQ9DB00
SMRiQ9DB00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217912, 3 interactors
STRINGi10090.ENSMUSP00000080397

PTM databases

iPTMnetiQ9DB00
PhosphoSitePlusiQ9DB00

Proteomic databases

EPDiQ9DB00
MaxQBiQ9DB00
PaxDbiQ9DB00
PRIDEiQ9DB00

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76022
UCSCiuc008pxb.1 mouse

Organism-specific databases

CTDi54856
MGIiMGI:1917579 Gon4l
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHDM Eukaryota
ENOG410XS4M LUCA
HOGENOMiHOG000082442
HOVERGENiHBG081563
InParanoidiQ9DB00

Miscellaneous databases

ChiTaRSiGon4l mouse
EvolutionaryTraceiQ9DB00
PROiPR:Q9DB00
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR033277 GON-4-like
IPR009057 Homeobox-like_sf
IPR017877 Myb-like_dom
IPR003822 PAH
IPR036600 PAH_sf
PANTHERiPTHR16088:SF11 PTHR16088:SF11, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47762 SSF47762, 2 hits
PROSITEiView protein in PROSITE
PS50090 MYB_LIKE, 1 hit
PS51477 PAH, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGON4L_MOUSE
AccessioniPrimary (citable) accession number: Q9DB00
Secondary accession number(s): E9Q5N3, Q80TB4, Q91YI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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