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Protein

WAP four-disulfide core domain protein 2

Gene

Wfdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Broad range protease inhibitor.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI17.004

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 2
Alternative name(s):
WAP domain-containing protein HE4
Gene namesi
Name:Wfdc2
Synonyms:He4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914951 Wfdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004137126 – 174WAP four-disulfide core domain protein 2Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 62PROSITE-ProRule annotation
Disulfide bondi45 ↔ 66PROSITE-ProRule annotation
Disulfide bondi49 ↔ 61PROSITE-ProRule annotation
Disulfide bondi55 ↔ 70PROSITE-ProRule annotation
Disulfide bondi132 ↔ 160PROSITE-ProRule annotation
Disulfide bondi143 ↔ 164PROSITE-ProRule annotation
Disulfide bondi147 ↔ 159PROSITE-ProRule annotation
Disulfide bondi153 ↔ 169PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9DAU7
PaxDbiQ9DAU7
PeptideAtlasiQ9DAU7
PRIDEiQ9DAU7

Expressioni

Gene expression databases

BgeeiENSMUSG00000017723 Expressed in 199 organ(s), highest expression level in carotid body
CleanExiMM_WFDC2
ExpressionAtlasiQ9DAU7 baseline and differential
GenevisibleiQ9DAU7 MM

Interactioni

Subunit structurei

Homotrimer; disulfide-linked.By similarity

Protein-protein interaction databases

IntActiQ9DAU7, 1 interactor
MINTiQ9DAU7
STRINGi10090.ENSMUSP00000017867

Structurei

3D structure databases

ProteinModelPortaliQ9DAU7
SMRiQ9DAU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 74WAP 1PROSITE-ProRule annotationAdd BLAST46
Domaini125 – 173WAP 2PROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J36N Eukaryota
ENOG41125F3 LUCA
GeneTreeiENSGT00730000111410
HOGENOMiHOG000115819
HOVERGENiHBG018073
InParanoidiQ9DAU7
OrthoDBiEOG091G0UW4
PhylomeDBiQ9DAU7

Family and domain databases

Gene3Di4.10.75.10, 2 hits
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 2 hits
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 2 hits
SUPFAMiSSF57256 SSF57256, 2 hits
PROSITEiView protein in PROSITE
PS51390 WAP, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9DAU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPACRLCLLA AGLLLGLLLF TPISATGTDA EKPGECPQLE PITDCVLECT
60 70 80 90 100
LDKDCADNRK CCQAGCSSVC SKPNGPSEGE LSGTDTKLSE TGTTTQSAGL
110 120 130 140 150
DHTTKPPGGQ VSTKPPAVTR EGLGVREKQG TCPSVDIPKL GLCEDQCQVD
160 170
SQCSGNMKCC RNGCGKMACT TPKF
Length:174
Mass (Da):18,032
Last modified:June 1, 2001 - v1
Checksum:i82484E28ED6F1E20
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A5G5A2A5G5_MOUSE
WAP four-disulfide core domain prot...
Wfdc2
122Annotation score:
A2A5G4A2A5G4_MOUSE
WAP four-disulfide core domain prot...
Wfdc2
74Annotation score:
A2A5G6A2A5G6_MOUSE
WAP four-disulfide core domain prot...
Wfdc2
131Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334269 mRNA Translation: AAL73189.1
AK005519 mRNA Translation: BAB24094.1
CCDSiCCDS17040.1
RefSeqiNP_080599.1, NM_026323.2
UniGeneiMm.27289

Genome annotation databases

EnsembliENSMUST00000017867; ENSMUSP00000017867; ENSMUSG00000017723
GeneIDi67701
KEGGimmu:67701
UCSCiuc008nve.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334269 mRNA Translation: AAL73189.1
AK005519 mRNA Translation: BAB24094.1
CCDSiCCDS17040.1
RefSeqiNP_080599.1, NM_026323.2
UniGeneiMm.27289

3D structure databases

ProteinModelPortaliQ9DAU7
SMRiQ9DAU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DAU7, 1 interactor
MINTiQ9DAU7
STRINGi10090.ENSMUSP00000017867

Protein family/group databases

MEROPSiI17.004

Proteomic databases

MaxQBiQ9DAU7
PaxDbiQ9DAU7
PeptideAtlasiQ9DAU7
PRIDEiQ9DAU7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017867; ENSMUSP00000017867; ENSMUSG00000017723
GeneIDi67701
KEGGimmu:67701
UCSCiuc008nve.1 mouse

Organism-specific databases

CTDi10406
MGIiMGI:1914951 Wfdc2

Phylogenomic databases

eggNOGiENOG410J36N Eukaryota
ENOG41125F3 LUCA
GeneTreeiENSGT00730000111410
HOGENOMiHOG000115819
HOVERGENiHBG018073
InParanoidiQ9DAU7
OrthoDBiEOG091G0UW4
PhylomeDBiQ9DAU7

Miscellaneous databases

PROiPR:Q9DAU7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017723 Expressed in 199 organ(s), highest expression level in carotid body
CleanExiMM_WFDC2
ExpressionAtlasiQ9DAU7 baseline and differential
GenevisibleiQ9DAU7 MM

Family and domain databases

Gene3Di4.10.75.10, 2 hits
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 2 hits
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 2 hits
SUPFAMiSSF57256 SSF57256, 2 hits
PROSITEiView protein in PROSITE
PS51390 WAP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiWFDC2_MOUSE
AccessioniPrimary (citable) accession number: Q9DAU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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