UniProtKB - Q9DAT2 (MRGBP_MOUSE)
MRG/MORF4L-binding protein
Mrgbp
Functioni
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- histone acetylation Source: GO_Central
- histone H2A acetylation Source: Ensembl
- histone H4 acetylation Source: Ensembl
- positive regulation of double-strand break repair via homologous recombination Source: Ensembl
- regulation of cell cycle Source: Ensembl
- regulation of growth Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | Growth regulation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: MRG/MORF4L-binding proteinAlternative name(s): MRG-binding protein |
Gene namesi | Name:Mrgbp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920497, Mrgbp |
VEuPathDBi | HostDB:ENSMUSG00000027569 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- NuA4 histone acetyltransferase complex Source: GO_Central
- nucleoplasm Source: MGI
Other locations
- nucleosome Source: Ensembl
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000215877 | 2 – 204 | MRG/MORF4L-binding proteinAdd BLAST | 203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineBy similarity | 1 | |
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Cross-linki | 127 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 191 | PhosphoserineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9DAT2 |
jPOSTi | Q9DAT2 |
MaxQBi | Q9DAT2 |
PaxDbi | Q9DAT2 |
PeptideAtlasi | Q9DAT2 |
PRIDEi | Q9DAT2 |
ProteomicsDBi | 290313 [Q9DAT2-1] 290314 [Q9DAT2-2] |
PTM databases
iPTMneti | Q9DAT2 |
PhosphoSitePlusi | Q9DAT2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027569, Expressed in spermatocyte and 252 other tissues |
Genevisiblei | Q9DAT2, MM |
Interactioni
Subunit structurei
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 215861, 5 interactors |
ComplexPortali | CPX-990, NuA4 histone acetyltransferase complex |
IntActi | Q9DAT2, 1 interactor |
STRINGi | 10090.ENSMUSP00000029085 |
Miscellaneous databases
RNActi | Q9DAT2, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 128 – 204 | DisorderedSequence analysisAdd BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 154 – 184 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4051, Eukaryota |
GeneTreei | ENSGT00390000007823 |
HOGENOMi | CLU_080546_0_0_1 |
InParanoidi | Q9DAT2 |
OMAi | EEREFCL |
OrthoDBi | 1476852at2759 |
PhylomeDBi | Q9DAT2 |
TreeFami | TF326334 |
Family and domain databases
InterProi | View protein in InterPro IPR012423, Eaf7/MRGBP |
PANTHERi | PTHR13581, PTHR13581, 1 hit |
Pfami | View protein in Pfam PF07904, Eaf7, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGEAEVGGTG APGDKGPGEA APSPAEETVV WSPEVEVCLF HAMLGHKPVG
60 70 80 90 100
VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN
110 120 130 140 150
PERNFVLPDE IIQEVREGKV VIEEEMKEEM KEDVDPHSGA DDVFSSSGSL
160 170 180 190 200
GKALEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK
RRRT
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | P → S in BAC35046 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 110 | E → D in BAC35046 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 156 | K → E in BAB24117 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003793 | 119 – 204 | KVVIE…KRRRT → ETRPPPGLGIKKASPGQRWG GLGPPGRCKDPAQTIPPVAP GRFWEPRAGESGAQRQSPDG CRLVMDAEACVGSENRKQSW PDRPPALATTVGFQ in isoform 2. 1 PublicationAdd BLAST | 86 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005551 mRNA Translation: BAB24117.1 Frameshift. AK052575 mRNA Translation: BAC35046.1 AL669926 Genomic DNA No translation available. CH466626 Genomic DNA Translation: EDL07342.1 BC116732 mRNA Translation: AAI16733.1 BC116734 mRNA Translation: AAI16735.1 |
CCDSi | CCDS17178.1 [Q9DAT2-1] |
RefSeqi | NP_082755.1, NM_028479.1 [Q9DAT2-1] |
Genome annotation databases
Ensembli | ENSMUST00000029085; ENSMUSP00000029085; ENSMUSG00000027569 [Q9DAT2-1] ENSMUST00000169630; ENSMUSP00000127747; ENSMUSG00000027569 [Q9DAT2-1] |
GeneIDi | 73247 |
KEGGi | mmu:73247 |
UCSCi | uc008ojh.1, mouse [Q9DAT2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005551 mRNA Translation: BAB24117.1 Frameshift. AK052575 mRNA Translation: BAC35046.1 AL669926 Genomic DNA No translation available. CH466626 Genomic DNA Translation: EDL07342.1 BC116732 mRNA Translation: AAI16733.1 BC116734 mRNA Translation: AAI16735.1 |
CCDSi | CCDS17178.1 [Q9DAT2-1] |
RefSeqi | NP_082755.1, NM_028479.1 [Q9DAT2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 215861, 5 interactors |
ComplexPortali | CPX-990, NuA4 histone acetyltransferase complex |
IntActi | Q9DAT2, 1 interactor |
STRINGi | 10090.ENSMUSP00000029085 |
PTM databases
iPTMneti | Q9DAT2 |
PhosphoSitePlusi | Q9DAT2 |
Proteomic databases
EPDi | Q9DAT2 |
jPOSTi | Q9DAT2 |
MaxQBi | Q9DAT2 |
PaxDbi | Q9DAT2 |
PeptideAtlasi | Q9DAT2 |
PRIDEi | Q9DAT2 |
ProteomicsDBi | 290313 [Q9DAT2-1] 290314 [Q9DAT2-2] |
Protocols and materials databases
Antibodypediai | 14923, 175 antibodies from 26 providers |
Genome annotation databases
Ensembli | ENSMUST00000029085; ENSMUSP00000029085; ENSMUSG00000027569 [Q9DAT2-1] ENSMUST00000169630; ENSMUSP00000127747; ENSMUSG00000027569 [Q9DAT2-1] |
GeneIDi | 73247 |
KEGGi | mmu:73247 |
UCSCi | uc008ojh.1, mouse [Q9DAT2-1] |
Organism-specific databases
CTDi | 55257 |
MGIi | MGI:1920497, Mrgbp |
VEuPathDBi | HostDB:ENSMUSG00000027569 |
Phylogenomic databases
eggNOGi | KOG4051, Eukaryota |
GeneTreei | ENSGT00390000007823 |
HOGENOMi | CLU_080546_0_0_1 |
InParanoidi | Q9DAT2 |
OMAi | EEREFCL |
OrthoDBi | 1476852at2759 |
PhylomeDBi | Q9DAT2 |
TreeFami | TF326334 |
Miscellaneous databases
BioGRID-ORCSi | 73247, 11 hits in 65 CRISPR screens |
ChiTaRSi | Mrgbp, mouse |
PROi | PR:Q9DAT2 |
RNActi | Q9DAT2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027569, Expressed in spermatocyte and 252 other tissues |
Genevisiblei | Q9DAT2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR012423, Eaf7/MRGBP |
PANTHERi | PTHR13581, PTHR13581, 1 hit |
Pfami | View protein in Pfam PF07904, Eaf7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MRGBP_MOUSE | |
Accessioni | Q9DAT2Primary (citable) accession number: Q9DAT2 Secondary accession number(s): Q14AR7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | September 18, 2013 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families