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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

Gng12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • cerebral cortex development Source: GO_Central
  • G protein-coupled receptor signaling pathway Source: InterPro
  • response to lipopolysaccharide Source: GO_Central

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene namesi
Name:Gng12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1336171 Gng12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000126692 – 69Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Add BLAST68
PropeptideiPRO_000001267070 – 72Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei10PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei42PhosphotyrosineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei69Cysteine methyl esterBy similarity1
Lipidationi69S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9DAS9
MaxQBiQ9DAS9
PaxDbiQ9DAS9
PeptideAtlasiQ9DAS9
PRIDEiQ9DAS9
TopDownProteomicsiQ9DAS9

PTM databases

iPTMnetiQ9DAS9
PhosphoSitePlusiQ9DAS9

Expressioni

Gene expression databases

BgeeiENSMUSG00000036402 Expressed in 296 organ(s), highest expression level in uterus
ExpressionAtlasiQ9DAS9 baseline and differential
GenevisibleiQ9DAS9 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199985, 1 interactor
IntActiQ9DAS9, 4 interactors
STRINGi10090.ENSMUSP00000046557

Structurei

3D structure databases

ProteinModelPortaliQ9DAS9
SMRiQ9DAS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiQ9DAS9
KOiK04347
OMAiDHESDDC
OrthoDBiEOG091G17J0
PhylomeDBiQ9DAS9
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9DAS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKTASTNS IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD
60 70
PLLMGIPTSE NPFKDKKTCI IL
Length:72
Mass (Da):7,997
Last modified:January 23, 2007 - v3
Checksum:iA4D56F3BD697E7B4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SVT3A0A0N4SVT3_MOUSE
Guanine nucleotide-binding protein ...
Gng12
65Annotation score:
A0A0N4SW28A0A0N4SW28_MOUSE
Guanine nucleotide-binding protein ...
Gng12
83Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005561 mRNA Translation: BAB24121.1
AK033422 mRNA Translation: BAC28280.1
AK148765 mRNA Translation: BAE28660.1
AK159872 mRNA Translation: BAE35445.1
AK162342 mRNA Translation: BAE36863.1
AK166035 mRNA Translation: BAE38536.1
AK166299 mRNA Translation: BAE38688.1
BC040685 mRNA Translation: AAH40685.1
CCDSiCCDS39502.1
RefSeqiNP_001171027.1, NM_001177556.1
NP_001171028.1, NM_001177557.1
NP_001171029.1, NM_001177558.1
NP_001171030.1, NM_001177559.1
NP_001171031.1, NM_001177560.1
NP_079554.1, NM_025278.5
XP_006505605.1, XM_006505542.3
UniGeneiMm.234342

Genome annotation databases

EnsembliENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402
ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402
ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402
ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402
ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402
ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402
ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402
GeneIDi14701
KEGGimmu:14701
UCSCiuc009cew.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005561 mRNA Translation: BAB24121.1
AK033422 mRNA Translation: BAC28280.1
AK148765 mRNA Translation: BAE28660.1
AK159872 mRNA Translation: BAE35445.1
AK162342 mRNA Translation: BAE36863.1
AK166035 mRNA Translation: BAE38536.1
AK166299 mRNA Translation: BAE38688.1
BC040685 mRNA Translation: AAH40685.1
CCDSiCCDS39502.1
RefSeqiNP_001171027.1, NM_001177556.1
NP_001171028.1, NM_001177557.1
NP_001171029.1, NM_001177558.1
NP_001171030.1, NM_001177559.1
NP_001171031.1, NM_001177560.1
NP_079554.1, NM_025278.5
XP_006505605.1, XM_006505542.3
UniGeneiMm.234342

3D structure databases

ProteinModelPortaliQ9DAS9
SMRiQ9DAS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199985, 1 interactor
IntActiQ9DAS9, 4 interactors
STRINGi10090.ENSMUSP00000046557

PTM databases

iPTMnetiQ9DAS9
PhosphoSitePlusiQ9DAS9

Proteomic databases

EPDiQ9DAS9
MaxQBiQ9DAS9
PaxDbiQ9DAS9
PeptideAtlasiQ9DAS9
PRIDEiQ9DAS9
TopDownProteomicsiQ9DAS9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043148; ENSMUSP00000046557; ENSMUSG00000036402
ENSMUST00000114222; ENSMUSP00000109860; ENSMUSG00000036402
ENSMUST00000114224; ENSMUSP00000109862; ENSMUSG00000036402
ENSMUST00000114225; ENSMUSP00000109863; ENSMUSG00000036402
ENSMUST00000114226; ENSMUSP00000109864; ENSMUSG00000036402
ENSMUST00000114227; ENSMUSP00000109865; ENSMUSG00000036402
ENSMUST00000114228; ENSMUSP00000109866; ENSMUSG00000036402
GeneIDi14701
KEGGimmu:14701
UCSCiuc009cew.2 mouse

Organism-specific databases

CTDi55970
MGIiMGI:1336171 Gng12

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiQ9DAS9
KOiK04347
OMAiDHESDDC
OrthoDBiEOG091G17J0
PhylomeDBiQ9DAS9
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

ChiTaRSiGng12 mouse
PROiPR:Q9DAS9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036402 Expressed in 296 organ(s), highest expression level in uterus
ExpressionAtlasiQ9DAS9 baseline and differential
GenevisibleiQ9DAS9 MM

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG12_MOUSE
AccessioniPrimary (citable) accession number: Q9DAS9
Secondary accession number(s): Q544P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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