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Protein

Histone chaperone ASF1B

Gene

Asf1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA.1 Publication

GO - Molecular functioni

  • histone binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone, Chromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone chaperone ASF1B
Alternative name(s):
Anti-silencing function protein 1 homolog B
Short name:
mCIA-II
Gene namesi
Name:Asf1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914179 Asf1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840161 – 202Histone chaperone ASF1BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198Phosphoserine; by TLK2By similarity1

Post-translational modificationi

Phosphorylated by TLK2 (By similarity). Phosphorylated by TLK1.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DAP7
MaxQBiQ9DAP7
PaxDbiQ9DAP7
PeptideAtlasiQ9DAP7
PRIDEiQ9DAP7

PTM databases

iPTMnetiQ9DAP7
PhosphoSitePlusiQ9DAP7

Expressioni

Tissue specificityi

Highly expressed in testis. Restricted to premeiotic to meiotic stages during spermatogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000005470 Expressed in 245 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
GenevisibleiQ9DAP7 MM

Interactioni

Subunit structurei

Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with HAT1, NASP, TAF1, TLK1 and TLK2 (By similarity). Interacts with CDAN1 (By similarity). Found in a cytosolic complex with CDAN1, ASF1A, IPO4 and histones H3.1 and H4. Interacts with CREBBP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211816, 1 interactor
IntActiQ9DAP7, 5 interactors
MINTiQ9DAP7
STRINGi10090.ENSMUSP00000005607

Structurei

3D structure databases

ProteinModelPortaliQ9DAP7
SMRiQ9DAP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 156Interaction with histone H3 and CHAF1BBy similarityAdd BLAST156

Sequence similaritiesi

Belongs to the ASF1 family.Curated

Phylogenomic databases

eggNOGiKOG3265 Eukaryota
COG5137 LUCA
GeneTreeiENSGT00390000004692
HOGENOMiHOG000197425
HOVERGENiHBG105617
InParanoidiQ9DAP7
KOiK10753
OMAiHINWEGC
OrthoDBiEOG091G0K07
PhylomeDBiQ9DAP7
TreeFamiTF106429

Family and domain databases

Gene3Di2.60.40.1490, 1 hit
InterProiView protein in InterPro
IPR006818 ASF1-like
IPR036747 ASF1-like_sf
PANTHERiPTHR12040 PTHR12040, 1 hit
PfamiView protein in Pfam
PF04729 ASF1_hist_chap, 1 hit
SUPFAMiSSF101546 SSF101546, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DAP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVSVLNVA VLENPSPFHS PFRFEISFEC SEALSDDLEW KIIYVGSAES
60 70 80 90 100
EEFDQILDSV LVGPVPAGRH MFVFQADAPN PSLIPETDAV GVTVVLITCT
110 120 130 140 150
YHGQEFIRVG YYVNNEYPDP ELRENPPPKP DFSQLQRNIL ASNPRVTRFH
160 170 180 190 200
INWDNNPDSL EAIENQDPNV DFSLSLSCTP VKSLGLPSCI PGLLPENSMD

CI
Length:202
Mass (Da):22,464
Last modified:June 1, 2001 - v1
Checksum:iA02546180DA18A48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93T → N in BAC36978 (PubMed:16141072).Curated1
Sequence conflicti155N → K in BAC36978 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005646 mRNA Translation: BAB24166.1
AK019594 mRNA Translation: BAB31809.1
AK077005 mRNA Translation: BAC36561.1
AK077718 mRNA Translation: BAC36978.1
AK134906 mRNA Translation: BAE22334.1
AK150818 mRNA Translation: BAE29881.1
AK151951 mRNA Translation: BAE30824.1
AK165322 mRNA Translation: BAE38137.1
BC003428 mRNA Translation: AAH03428.1
CCDSiCCDS22462.1
RefSeqiNP_077146.1, NM_024184.2
UniGeneiMm.29680

Genome annotation databases

EnsembliENSMUST00000005607; ENSMUSP00000005607; ENSMUSG00000005470
GeneIDi66929
KEGGimmu:66929
UCSCiuc009mlk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005646 mRNA Translation: BAB24166.1
AK019594 mRNA Translation: BAB31809.1
AK077005 mRNA Translation: BAC36561.1
AK077718 mRNA Translation: BAC36978.1
AK134906 mRNA Translation: BAE22334.1
AK150818 mRNA Translation: BAE29881.1
AK151951 mRNA Translation: BAE30824.1
AK165322 mRNA Translation: BAE38137.1
BC003428 mRNA Translation: AAH03428.1
CCDSiCCDS22462.1
RefSeqiNP_077146.1, NM_024184.2
UniGeneiMm.29680

3D structure databases

ProteinModelPortaliQ9DAP7
SMRiQ9DAP7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211816, 1 interactor
IntActiQ9DAP7, 5 interactors
MINTiQ9DAP7
STRINGi10090.ENSMUSP00000005607

PTM databases

iPTMnetiQ9DAP7
PhosphoSitePlusiQ9DAP7

Proteomic databases

EPDiQ9DAP7
MaxQBiQ9DAP7
PaxDbiQ9DAP7
PeptideAtlasiQ9DAP7
PRIDEiQ9DAP7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005607; ENSMUSP00000005607; ENSMUSG00000005470
GeneIDi66929
KEGGimmu:66929
UCSCiuc009mlk.1 mouse

Organism-specific databases

CTDi55723
MGIiMGI:1914179 Asf1b

Phylogenomic databases

eggNOGiKOG3265 Eukaryota
COG5137 LUCA
GeneTreeiENSGT00390000004692
HOGENOMiHOG000197425
HOVERGENiHBG105617
InParanoidiQ9DAP7
KOiK10753
OMAiHINWEGC
OrthoDBiEOG091G0K07
PhylomeDBiQ9DAP7
TreeFamiTF106429

Miscellaneous databases

PROiPR:Q9DAP7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005470 Expressed in 245 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
GenevisibleiQ9DAP7 MM

Family and domain databases

Gene3Di2.60.40.1490, 1 hit
InterProiView protein in InterPro
IPR006818 ASF1-like
IPR036747 ASF1-like_sf
PANTHERiPTHR12040 PTHR12040, 1 hit
PfamiView protein in Pfam
PF04729 ASF1_hist_chap, 1 hit
SUPFAMiSSF101546 SSF101546, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASF1B_MOUSE
AccessioniPrimary (citable) accession number: Q9DAP7
Secondary accession number(s): Q8BP41, Q9CTX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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