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Protein

Rho-related BTB domain-containing protein 1

Gene

Rhobtb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPSequence analysis8
Nucleotide bindingi84 – 88GTPSequence analysis5
Nucleotide bindingi140 – 143GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 1
Gene namesi
Name:Rhobtb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1916538 Rhobtb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989611 – 695Rho-related BTB domain-containing protein 1Add BLAST695

Proteomic databases

MaxQBiQ9DAK3
PaxDbiQ9DAK3
PRIDEiQ9DAK3

PTM databases

iPTMnetiQ9DAK3
PhosphoSitePlusiQ9DAK3

Expressioni

Tissue specificityi

Highest expression in heart and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000019944 Expressed in 191 organ(s), highest expression level in cumulus cell
CleanExiMM_RHOBTB1
ExpressionAtlasiQ9DAK3 baseline and differential
GenevisibleiQ9DAK3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213337, 5 interactors
STRINGi10090.ENSMUSP00000020101

Structurei

3D structure databases

ProteinModelPortaliQ9DAK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 426BTB 1PROSITE-ProRule annotationAdd BLAST161
Domaini484 – 551BTB 2PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 210Rho-likeAdd BLAST210

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000007723
HOVERGENiHBG054987
InParanoidiQ9DAK3
KOiK07868
OMAiEMQVNPV
OrthoDBiEOG091G03I3
PhylomeDBiQ9DAK3
TreeFamiTF323347

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR027417 P-loop_NTPase
IPR011333 SKP1/BTB/POZ_sf
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00071 Ras, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54695 SSF54695, 2 hits
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 2 hits
PS51420 RHO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9DAK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV
60 70 80 90 100
PTVWAIDQYR VCQEVLERSR DVVDEVSISL RLWDTFGDHH KDRRFAYGRS
110 120 130 140 150
DVVVLCFSIA NPNSLNHVKT MWYQEIKHFC PRTPVVLVGC QLDLRYADLE
160 170 180 190 200
AVNRARRPLA RPIKRGDILP PEKGREVAKE LGIPYYETSV FDQFGIKDVF
210 220 230 240 250
DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKVPECPS
260 270 280 290 300
AGTSDAACLL DNPLCADVLF VLHDEEHIFA HRIYLATSSS KFYDLFLMEC
310 320 330 340 350
EESPCWGGGA GEEVPCRDFQ GRTQSLGSAE EGKEGPQRTP QADPGASSGQ
360 370 380 390 400
DLPESLALQM EASGSEGHAL SGWSKGFVSM HREVRVNPIS KRVGPVTVVR
410 420 430 440 450
LDPSMQSGPF RTLLRFLYSG QLDEKEKDLL GLAQMAEVLE MFDLRMMVEN
460 470 480 490 500
IMNKEAFMNQ EITKAFHVRK ANRIKECLSK GTFSDVTFTL DDGAISAHKP
510 520 530 540 550
LLICSCEWMA AMFGGSFVES ANREVHLPNI NKMSMQAVLE YLYTKQLSPN
560 570 580 590 600
LDLDPLELIA LANRFCLTHL VALVEQHAVQ ELTKAAVSGV SIDGEVLSYL
610 620 630 640 650
ELAQFHNANQ LAAWCLHHIC TNYNSVCSKF RKEIKSKSAD NQEYFERHRW
660 670 680 690
PPVWYLKEED HYQRVKRERE KEDLALNKHH SRRKWCFWHS SPAVA
Length:695
Mass (Da):78,819
Last modified:July 27, 2011 - v2
Checksum:iAA5F75C033004641
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ72E9PZ72_MOUSE
Rho-related BTB domain-containing p...
Rhobtb1
633Annotation score:
E9QAZ7E9QAZ7_MOUSE
Rho-related BTB domain-containing p...
Rhobtb1
97Annotation score:
E9Q1X7E9Q1X7_MOUSE
Rho-related BTB domain-containing p...
Rhobtb1
101Annotation score:
E9Q922E9Q922_MOUSE
Rho-related BTB domain-containing p...
Rhobtb1
98Annotation score:
F6UIH6F6UIH6_MOUSE
Rho-related BTB domain-containing p...
Rhobtb1
96Annotation score:
E9PYH9E9PYH9_MOUSE
Rho-related BTB domain-containing p...
Rhobtb1
100Annotation score:
E9PZ17E9PZ17_MOUSE
Rho-related BTB domain-containing p...
Rhobtb1
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti636S → Y in BAB24229 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005770 mRNA Translation: BAB24229.1
CH466553 Genomic DNA Translation: EDL32000.1
CH466553 Genomic DNA Translation: EDL32001.1
CH466553 Genomic DNA Translation: EDL32002.1
CH466553 Genomic DNA Translation: EDL32003.1
CH466553 Genomic DNA Translation: EDL32004.1
BC137646 mRNA Translation: AAI37647.1
BC137647 mRNA Translation: AAI37648.1
CCDSiCCDS35930.1
RefSeqiNP_001074816.1, NM_001081347.1
NP_001239565.1, NM_001252636.1
NP_001239566.1, NM_001252637.1
XP_006514111.1, XM_006514048.3
XP_006514112.1, XM_006514049.3
XP_006514114.1, XM_006514051.3
XP_011241855.1, XM_011243553.2
UniGeneiMm.26659

Genome annotation databases

EnsembliENSMUST00000020101; ENSMUSP00000020101; ENSMUSG00000019944
ENSMUST00000067908; ENSMUSP00000065095; ENSMUSG00000019944
ENSMUST00000164034; ENSMUSP00000132068; ENSMUSG00000019944
GeneIDi69288
KEGGimmu:69288
UCSCiuc007fmp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005770 mRNA Translation: BAB24229.1
CH466553 Genomic DNA Translation: EDL32000.1
CH466553 Genomic DNA Translation: EDL32001.1
CH466553 Genomic DNA Translation: EDL32002.1
CH466553 Genomic DNA Translation: EDL32003.1
CH466553 Genomic DNA Translation: EDL32004.1
BC137646 mRNA Translation: AAI37647.1
BC137647 mRNA Translation: AAI37648.1
CCDSiCCDS35930.1
RefSeqiNP_001074816.1, NM_001081347.1
NP_001239565.1, NM_001252636.1
NP_001239566.1, NM_001252637.1
XP_006514111.1, XM_006514048.3
XP_006514112.1, XM_006514049.3
XP_006514114.1, XM_006514051.3
XP_011241855.1, XM_011243553.2
UniGeneiMm.26659

3D structure databases

ProteinModelPortaliQ9DAK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213337, 5 interactors
STRINGi10090.ENSMUSP00000020101

PTM databases

iPTMnetiQ9DAK3
PhosphoSitePlusiQ9DAK3

Proteomic databases

MaxQBiQ9DAK3
PaxDbiQ9DAK3
PRIDEiQ9DAK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020101; ENSMUSP00000020101; ENSMUSG00000019944
ENSMUST00000067908; ENSMUSP00000065095; ENSMUSG00000019944
ENSMUST00000164034; ENSMUSP00000132068; ENSMUSG00000019944
GeneIDi69288
KEGGimmu:69288
UCSCiuc007fmp.1 mouse

Organism-specific databases

CTDi9886
MGIiMGI:1916538 Rhobtb1

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000007723
HOVERGENiHBG054987
InParanoidiQ9DAK3
KOiK07868
OMAiEMQVNPV
OrthoDBiEOG091G03I3
PhylomeDBiQ9DAK3
TreeFamiTF323347

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiRhobtb1 mouse
PROiPR:Q9DAK3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019944 Expressed in 191 organ(s), highest expression level in cumulus cell
CleanExiMM_RHOBTB1
ExpressionAtlasiQ9DAK3 baseline and differential
GenevisibleiQ9DAK3 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR027417 P-loop_NTPase
IPR011333 SKP1/BTB/POZ_sf
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00071 Ras, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54695 SSF54695, 2 hits
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 2 hits
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHBT1_MOUSE
AccessioniPrimary (citable) accession number: Q9DAK3
Secondary accession number(s): B2RPX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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