UniProtKB - Q9DAK2 (PACRG_MOUSE)
Protein
Parkin coregulated gene protein homolog
Gene
Pacrg
Organism
Mus musculus (Mouse)
Status
Functioni
Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity).By similarity
GO - Molecular functioni
- actin binding Source: MGI
- alpha-tubulin binding Source: MGI
- beta-tubulin binding Source: MGI
- chaperone binding Source: MGI
- G protein-coupled receptor binding Source: MGI
- heat shock protein binding Source: MGI
- Hsp70 protein binding Source: MGI
- Hsp90 protein binding Source: MGI
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cellular response to unfolded protein Source: ParkinsonsUK-UCL
- negative regulation of cell death Source: ParkinsonsUK-UCL
- spermatid development Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Parkin coregulated gene protein homologAlternative name(s): Hypertension-related protein 1-like protein PARK2 coregulated gene protein |
Gene namesi | Name:Pacrg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916560, Pacrg |
Subcellular locationi
Cytosol
- cytosol Source: ParkinsonsUK-UCL
Mitochondrion
- mitochondrion Source: MGI
Other locations
- cell body Source: MGI
- cilium Source: MGI
- neuron projection Source: ParkinsonsUK-UCL
- sperm midpiece Source: MGI
- vesicle Source: ParkinsonsUK-UCL
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058170 | 1 – 241 | Parkin coregulated gene protein homologAdd BLAST | 241 |
Proteomic databases
MaxQBi | Q9DAK2 |
PaxDbi | Q9DAK2 |
PRIDEi | Q9DAK2 |
PTM databases
PhosphoSitePlusi | Q9DAK2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037196, Expressed in testis and 175 other tissues |
ExpressionAtlasi | Q9DAK2, baseline and differential |
Genevisiblei | Q9DAK2, MM |
Interactioni
Subunit structurei
Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components.
Interacts with STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7 and CCT8 (By similarity).
Interacts with MEIG1.
By similarity1 PublicationBinary interactionsi
Q9DAK2
With | #Exp. | IntAct |
---|---|---|
Meig1 [Q61845] | 3 | EBI-8572392,EBI-15805257 |
GO - Molecular functioni
- actin binding Source: MGI
- alpha-tubulin binding Source: MGI
- beta-tubulin binding Source: MGI
- chaperone binding Source: MGI
- G protein-coupled receptor binding Source: MGI
- heat shock protein binding Source: MGI
- Hsp70 protein binding Source: MGI
- Hsp90 protein binding Source: MGI
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
DIPi | DIP-48983N |
IntActi | Q9DAK2, 2 interactors |
MINTi | Q9DAK2 |
STRINGi | 10090.ENSMUSP00000044376 |
Miscellaneous databases
RNActi | Q9DAK2, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG3961, Eukaryota |
GeneTreei | ENSGT00940000157330 |
HOGENOMi | CLU_073223_1_0_1 |
InParanoidi | Q9DAK2 |
OMAi | INGPIHE |
OrthoDBi | 1095804at2759 |
PhylomeDBi | Q9DAK2 |
TreeFami | TF321123 |
Family and domain databases
InterProi | View protein in InterPro IPR019399, Parkin_co-regulated_protein |
PANTHERi | PTHR21207, PTHR21207, 1 hit |
Pfami | View protein in Pfam PF10274, ParcG, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9DAK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKRTKLLPQ QTFQVHQPRS LVSEGFTVKA MMKNSVVRGP PVAGAFKERP
60 70 80 90 100
AKPTTFRKCY ERGDFPIALE HDSKGNKIAW KVEIEKLDYH HYLPLFFDGL
110 120 130 140 150
SEMTFPYEFF ARRGIHDMLE HGGNKILPVI PQLIIPIKNA LNLRNRQIIC
160 170 180 190 200
VTLKVLQHLV VSSEMVGEAL LPYYRQILPI LNIFKNMNVN SGDGIDYSQQ
210 220 230 240
KRENIGDLIQ ETLEAFERYG GEDAFINIKY MVPTYESCLL N
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005771 mRNA Translation: BAB24230.1 AC109609 Genomic DNA Translation: AAP94052.1 AF549257 Genomic DNA Translation: AAO16245.1 |
CCDSi | CCDS28388.1 |
RefSeqi | NP_081308.1, NM_027032.2 |
Genome annotation databases
Ensembli | ENSMUST00000041463; ENSMUSP00000044376; ENSMUSG00000037196 |
GeneIDi | 69310 |
KEGGi | mmu:69310 |
UCSCi | uc008akg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005771 mRNA Translation: BAB24230.1 AC109609 Genomic DNA Translation: AAP94052.1 AF549257 Genomic DNA Translation: AAO16245.1 |
CCDSi | CCDS28388.1 |
RefSeqi | NP_081308.1, NM_027032.2 |
3D structure databases
SMRi | Q9DAK2 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-48983N |
IntActi | Q9DAK2, 2 interactors |
MINTi | Q9DAK2 |
STRINGi | 10090.ENSMUSP00000044376 |
PTM databases
PhosphoSitePlusi | Q9DAK2 |
Proteomic databases
MaxQBi | Q9DAK2 |
PaxDbi | Q9DAK2 |
PRIDEi | Q9DAK2 |
Protocols and materials databases
Antibodypediai | 20047, 152 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000041463; ENSMUSP00000044376; ENSMUSG00000037196 |
GeneIDi | 69310 |
KEGGi | mmu:69310 |
UCSCi | uc008akg.1, mouse |
Organism-specific databases
CTDi | 135138 |
MGIi | MGI:1916560, Pacrg |
Phylogenomic databases
eggNOGi | KOG3961, Eukaryota |
GeneTreei | ENSGT00940000157330 |
HOGENOMi | CLU_073223_1_0_1 |
InParanoidi | Q9DAK2 |
OMAi | INGPIHE |
OrthoDBi | 1095804at2759 |
PhylomeDBi | Q9DAK2 |
TreeFami | TF321123 |
Miscellaneous databases
BioGRID-ORCSi | 69310, 0 hits in 17 CRISPR screens |
ChiTaRSi | Pacrg, mouse |
PROi | PR:Q9DAK2 |
RNActi | Q9DAK2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037196, Expressed in testis and 175 other tissues |
ExpressionAtlasi | Q9DAK2, baseline and differential |
Genevisiblei | Q9DAK2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019399, Parkin_co-regulated_protein |
PANTHERi | PTHR21207, PTHR21207, 1 hit |
Pfami | View protein in Pfam PF10274, ParcG, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PACRG_MOUSE | |
Accessioni | Q9DAK2Primary (citable) accession number: Q9DAK2 Secondary accession number(s): Q7TPF9, Q8CG20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot