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Protein

Parkin coregulated gene protein homolog

Gene

Pacrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to unfolded protein Source: ParkinsonsUK-UCL
  • negative regulation of cell death Source: ParkinsonsUK-UCL
  • spermatid development Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Parkin coregulated gene protein homolog
Alternative name(s):
Hypertension-related protein 1-like protein
PARK2 coregulated gene protein
Gene namesi
Name:Pacrg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1916560 Pacrg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581701 – 241Parkin coregulated gene protein homologAdd BLAST241

Proteomic databases

MaxQBiQ9DAK2
PaxDbiQ9DAK2
PRIDEiQ9DAK2

PTM databases

PhosphoSitePlusiQ9DAK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000037196 Expressed in 145 organ(s), highest expression level in testis
CleanExiMM_PACRG
ExpressionAtlasiQ9DAK2 baseline and differential
GenevisibleiQ9DAK2 MM

Interactioni

Subunit structurei

Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7 and CCT8 (By similarity). Interacts with MEIG1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Meig1Q618453EBI-8572392,EBI-15805257

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48983N
IntActiQ9DAK2, 2 interactors
MINTiQ9DAK2
STRINGi10090.ENSMUSP00000044376

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3961 Eukaryota
ENOG410XSXW LUCA
GeneTreeiENSGT00530000063549
HOGENOMiHOG000230829
HOVERGENiHBG053487
InParanoidiQ9DAK2
OMAiKDRNVNL
OrthoDBiEOG091G0HH5
PhylomeDBiQ9DAK2
TreeFamiTF321123

Family and domain databases

InterProiView protein in InterPro
IPR019399 Parkin_co-regulated_protein
PANTHERiPTHR21207 PTHR21207, 1 hit
PfamiView protein in Pfam
PF10274 ParcG, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DAK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRTKLLPQ QTFQVHQPRS LVSEGFTVKA MMKNSVVRGP PVAGAFKERP
60 70 80 90 100
AKPTTFRKCY ERGDFPIALE HDSKGNKIAW KVEIEKLDYH HYLPLFFDGL
110 120 130 140 150
SEMTFPYEFF ARRGIHDMLE HGGNKILPVI PQLIIPIKNA LNLRNRQIIC
160 170 180 190 200
VTLKVLQHLV VSSEMVGEAL LPYYRQILPI LNIFKNMNVN SGDGIDYSQQ
210 220 230 240
KRENIGDLIQ ETLEAFERYG GEDAFINIKY MVPTYESCLL N
Length:241
Mass (Da):27,726
Last modified:June 1, 2001 - v1
Checksum:iC871D590AA773AC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005771 mRNA Translation: BAB24230.1
AC109609 Genomic DNA Translation: AAP94052.1
AF549257 Genomic DNA Translation: AAO16245.1
CCDSiCCDS28388.1
RefSeqiNP_081308.1, NM_027032.2
UniGeneiMm.18889

Genome annotation databases

EnsembliENSMUST00000041463; ENSMUSP00000044376; ENSMUSG00000037196
GeneIDi69310
KEGGimmu:69310
UCSCiuc008akg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005771 mRNA Translation: BAB24230.1
AC109609 Genomic DNA Translation: AAP94052.1
AF549257 Genomic DNA Translation: AAO16245.1
CCDSiCCDS28388.1
RefSeqiNP_081308.1, NM_027032.2
UniGeneiMm.18889

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48983N
IntActiQ9DAK2, 2 interactors
MINTiQ9DAK2
STRINGi10090.ENSMUSP00000044376

PTM databases

PhosphoSitePlusiQ9DAK2

Proteomic databases

MaxQBiQ9DAK2
PaxDbiQ9DAK2
PRIDEiQ9DAK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041463; ENSMUSP00000044376; ENSMUSG00000037196
GeneIDi69310
KEGGimmu:69310
UCSCiuc008akg.1 mouse

Organism-specific databases

CTDi135138
MGIiMGI:1916560 Pacrg

Phylogenomic databases

eggNOGiKOG3961 Eukaryota
ENOG410XSXW LUCA
GeneTreeiENSGT00530000063549
HOGENOMiHOG000230829
HOVERGENiHBG053487
InParanoidiQ9DAK2
OMAiKDRNVNL
OrthoDBiEOG091G0HH5
PhylomeDBiQ9DAK2
TreeFamiTF321123

Miscellaneous databases

PROiPR:Q9DAK2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037196 Expressed in 145 organ(s), highest expression level in testis
CleanExiMM_PACRG
ExpressionAtlasiQ9DAK2 baseline and differential
GenevisibleiQ9DAK2 MM

Family and domain databases

InterProiView protein in InterPro
IPR019399 Parkin_co-regulated_protein
PANTHERiPTHR21207 PTHR21207, 1 hit
PfamiView protein in Pfam
PF10274 ParcG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPACRG_MOUSE
AccessioniPrimary (citable) accession number: Q9DAK2
Secondary accession number(s): Q7TPF9, Q8CG20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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