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Protein

Zinc finger and BTB domain-containing protein 43

Gene

Zbtb43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 43
Alternative name(s):
Zinc finger protein 297B
Gene namesi
Name:Zbtb43
Synonyms:Kiaa0414, Zfp297b, Znf297b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919084 Zbtb43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475201 – 467Zinc finger and BTB domain-containing protein 43Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki247Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei423PhosphothreonineBy similarity1
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9DAI4
PRIDEiQ9DAI4

PTM databases

PhosphoSitePlusiQ9DAI4

Expressioni

Gene expression databases

BgeeiENSMUSG00000026788 Expressed in 241 organ(s), highest expression level in skin of back
CleanExiMM_ZBTB43
ExpressionAtlasiQ9DAI4 baseline and differential
GenevisibleiQ9DAI4 MM

Interactioni

Subunit structurei

Interacts with BDP1.By similarity

Protein-protein interaction databases

BioGridi214963, 2 interactors
IntActiQ9DAI4, 1 interactor
STRINGi10090.ENSMUSP00000092645

Structurei

3D structure databases

ProteinModelPortaliQ9DAI4
SMRiQ9DAI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231975
HOVERGENiHBG056510
InParanoidiQ9DAI4
KOiK10514
PhylomeDBiQ9DAI4
TreeFamiTF333162

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9DAI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGTNSFQV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFQAHKAV
60 70 80 90 100
LAASSPYFCD QVLLKNSRRI VLPDVMNPRV FENILLFSYT GRLVMPAPEI
110 120 130 140 150
VSYLTAASFL QMWHVVDKCT EVLEGNPTVL CQKLNHGSDH QSPSSSNYNG
160 170 180 190 200
LVESFELGSG GHTDFPKAQE LRDGENEEES TKDELSSQVT EHEYLPSNSS
210 220 230 240 250
TEHDRLSTEM ASQDGEEGTN DSTEFHYTRP LYSKPSIMAH RRWIHVKPER
260 270 280 290 300
LEQAWDGMDV HAAYDEHQVT ESVNTMQTDH SAQPSGAEEE FQIVEKKVEV
310 320 330 340 350
EFDEQAEGSS YDEQVDFYGS SMEEFSGEKL GGNLIGHKQE AALAAGYSEN
360 370 380 390 400
IEMAMGIKEE ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY
410 420 430 440 450
GCSVCGKKFK MKHHLVGHMK IHTGIKPYEC NICAKRFMWR DSFHRHVTSC
460
TKSYEAAKAE QNTTEAN
Length:467
Mass (Da):52,652
Last modified:May 16, 2003 - v2
Checksum:i79F7882A93128110
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9N4G3X9N4_MOUSE
Zinc finger and BTB domain-containi...
Zbtb43 Zfp297b, mCG_49077
504Annotation score:
A2AUS2A2AUS2_MOUSE
Zinc finger and BTB domain-containi...
Zbtb43
71Annotation score:
A2AUS1A2AUS1_MOUSE
Zinc finger and BTB domain-containi...
Zbtb43
160Annotation score:

Sequence cautioni

The sequence BAB24254 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65559 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti258M → T in BAB24254 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005818 mRNA Translation: BAB24254.2 Different initiation.
AK122277 mRNA Translation: BAC65559.1 Different initiation.
BC043117 mRNA Translation: AAH43117.1
CCDSiCCDS15943.1
RefSeqiNP_001020765.1, NM_001025594.1
NP_082223.2, NM_027947.2
XP_006498411.1, XM_006498348.3
XP_006498412.1, XM_006498349.2
UniGeneiMm.44186

Genome annotation databases

EnsembliENSMUST00000028125; ENSMUSP00000028125; ENSMUSG00000026788
GeneIDi71834
KEGGimmu:71834
UCSCiuc008jhw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005818 mRNA Translation: BAB24254.2 Different initiation.
AK122277 mRNA Translation: BAC65559.1 Different initiation.
BC043117 mRNA Translation: AAH43117.1
CCDSiCCDS15943.1
RefSeqiNP_001020765.1, NM_001025594.1
NP_082223.2, NM_027947.2
XP_006498411.1, XM_006498348.3
XP_006498412.1, XM_006498349.2
UniGeneiMm.44186

3D structure databases

ProteinModelPortaliQ9DAI4
SMRiQ9DAI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214963, 2 interactors
IntActiQ9DAI4, 1 interactor
STRINGi10090.ENSMUSP00000092645

PTM databases

PhosphoSitePlusiQ9DAI4

Proteomic databases

PaxDbiQ9DAI4
PRIDEiQ9DAI4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028125; ENSMUSP00000028125; ENSMUSG00000026788
GeneIDi71834
KEGGimmu:71834
UCSCiuc008jhw.1 mouse

Organism-specific databases

CTDi23099
MGIiMGI:1919084 Zbtb43
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231975
HOVERGENiHBG056510
InParanoidiQ9DAI4
KOiK10514
PhylomeDBiQ9DAI4
TreeFamiTF333162

Miscellaneous databases

ChiTaRSiZbtb43 mouse
PROiPR:Q9DAI4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026788 Expressed in 241 organ(s), highest expression level in skin of back
CleanExiMM_ZBTB43
ExpressionAtlasiQ9DAI4 baseline and differential
GenevisibleiQ9DAI4 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT43_MOUSE
AccessioniPrimary (citable) accession number: Q9DAI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 16, 2003
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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