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Protein

GLIPR1-like protein 1

Gene

Glipr1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the binding between sperm and oocytes (PubMed:20219979). Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.By similarity1 Publication

GO - Biological processi

  • binding of sperm to zona pellucida Source: MGI

Keywordsi

Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
GLIPR1-like protein 1Curated
Gene namesi
Name:Glipr1l1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1916536 Glipr1l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500934822628 – 236GLIPR1-like protein 1Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi126N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Post-translational modificationi

N-glycosylated (PubMed:20219979). N-glycosylation decreases during the transit in the caput.By similarity1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9DAG6
PRIDEiQ9DAG6

PTM databases

PhosphoSitePlusiQ9DAG6

Expressioni

Tissue specificityi

Expressed in testis (at protein level). Little or no expression in other tissues tested.1 Publication

Developmental stagei

Detected at postnatal day 14 in developing testis (at protein level). Detected from postnatal day 18 onwards, with increasing levels through to postnatal day 36.1 Publication

Gene expression databases

BgeeiENSMUSG00000020213

Structurei

3D structure databases

SMRiQ9DAG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 178SCPSequence analysisAdd BLAST133

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000036879
HOVERGENiHBG072125
OMAiMAKAWAN
OrthoDBiEOG091G048D
TreeFamiTF316148

Family and domain databases

CDDicd05385 SCP_GLIPR-1_like, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034121 SCP_GLIPR-1-like
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DAG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKKKLNFL WTLVLYLIAS RLPKAFGKDL PRVPTITDPK FIDAFLNIHN
60 70 80 90 100
ELRRKVQPPA ADMNQLFWDQ QLAKLAKAWT RECKLAHNPC IKQRYECLED
110 120 130 140 150
YDFIGENIYL GRIETQPEDV VINWYNESKY FNFDFNTCSE MCGHYTQVVW
160 170 180 190 200
AKTVKIGCAV SNCPNLKGFS AGLFVCNYSP AGNFIGFRPY TRGDSCSMCG
210 220 230
QKTCENSLCR PMNRKTPHHK AACHVLVLGF ILQSLL
Length:236
Mass (Da):27,074
Last modified:June 1, 2001 - v1
Checksum:i239579A8BF7D1AAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159470 Genomic DNA No translation available.
AK005860 mRNA Translation: BAB24280.1
CCDSiCCDS48691.1
RefSeqiNP_081294.1, NM_027018.1
UniGeneiMm.47058

Genome annotation databases

EnsembliENSMUST00000073617; ENSMUSP00000073302; ENSMUSG00000020213
GeneIDi69286
KEGGimmu:69286
UCSCiuc007hak.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGPRL1_MOUSE
AccessioniPrimary (citable) accession number: Q9DAG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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