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Protein

CKLF-like MARVEL transmembrane domain-containing protein 2B

Gene

Cmtm2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 2B
Alternative name(s):
Chemokine-like factor superfamily member 2B
Gene namesi
Name:Cmtm2b
Synonyms:Cklfsf2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2447311 Cmtm2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861001 – 210CKLF-like MARVEL transmembrane domain-containing protein 2BAdd BLAST210

Proteomic databases

PaxDbiQ9DAC0
PRIDEiQ9DAC0

PTM databases

PhosphoSitePlusiQ9DAC0

Expressioni

Gene expression databases

BgeeiENSMUSG00000035785 Expressed in 19 organ(s), highest expression level in seminiferous tubule of testis
ExpressionAtlasiQ9DAC0 baseline and differential
GenevisibleiQ9DAC0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043127

Structurei

3D structure databases

SMRiQ9DAC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 157MARVELPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000005715
HOGENOMiHOG000111750
HOVERGENiHBG050993
InParanoidiQ9DAC0
OMAiMMDLMND
OrthoDBiEOG091G0POB
PhylomeDBiQ9DAC0
TreeFamiTF338711

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 4 (identifier: Q9DAC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPAPRART GGKKKDERRG FKGYKWEFRD SNKDFWAQGH AECKSLIMIL
60 70 80 90 100
LIAAMVCFQR VATHPIVILL LTMELSICAF FFFLYSLAIN RYIPFVFWPM
110 120 130 140 150
MDLMNDLACS TFLIGGIFFA LEARRELPVP YLTGMILMGV TAFISIIDLC
160 170 180 190 200
LQRRQFKSRK LRKFILLTPD RKGKKQDPKL LLMLAAKEDE EERQRELAEK
210
AKRESMDPGW
Length:210
Mass (Da):24,366
Last modified:June 1, 2001 - v1
Checksum:i795308551CD1AF10
GO
Isoform 1 (identifier: Q9DAR1-1) [UniParc]FASTAAdd to basket
Also known as: 1b
The sequence of this isoform can be found in the external entry Q9DAR1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:169
Mass (Da):19,553
GO
Isoform 2 (identifier: Q9DAR1-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9DAR1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:169
Mass (Da):19,484
GO
Isoform 3 (identifier: Q9DAR1-3) [UniParc]FASTAAdd to basket
Also known as: 1a
The sequence of this isoform can be found in the external entry Q9DAR1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:101
Mass (Da):11,500
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLT3A0A1D5RLT3_MOUSE
CKLF-like MARVEL transmembrane doma...
Cmtm2b
126Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162282 mRNA Translation: AAO34103.1
AY241872 mRNA Translation: AAP33494.1
AK005970 mRNA Translation: BAB24346.1
BC060997 mRNA Translation: AAH60997.1
CCDSiCCDS22576.1 [Q9DAC0-1]
RefSeqiNP_082800.1, NM_028524.3 [Q9DAC0-1]
UniGeneiMm.232593

Genome annotation databases

EnsembliENSMUST00000041973; ENSMUSP00000043127; ENSMUSG00000035785 [Q9DAC0-1]
GeneIDi75502
KEGGimmu:75502
UCSCiuc009nal.2 mouse [Q9DAC0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162282 mRNA Translation: AAO34103.1
AY241872 mRNA Translation: AAP33494.1
AK005970 mRNA Translation: BAB24346.1
BC060997 mRNA Translation: AAH60997.1
CCDSiCCDS22576.1 [Q9DAC0-1]
RefSeqiNP_082800.1, NM_028524.3 [Q9DAC0-1]
UniGeneiMm.232593

3D structure databases

SMRiQ9DAC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043127

PTM databases

PhosphoSitePlusiQ9DAC0

Proteomic databases

PaxDbiQ9DAC0
PRIDEiQ9DAC0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041973; ENSMUSP00000043127; ENSMUSG00000035785 [Q9DAC0-1]
GeneIDi75502
KEGGimmu:75502
UCSCiuc009nal.2 mouse [Q9DAC0-1]

Organism-specific databases

CTDi75502
MGIiMGI:2447311 Cmtm2b

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000005715
HOGENOMiHOG000111750
HOVERGENiHBG050993
InParanoidiQ9DAC0
OMAiMMDLMND
OrthoDBiEOG091G0POB
PhylomeDBiQ9DAC0
TreeFamiTF338711

Miscellaneous databases

PROiPR:Q9DAC0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035785 Expressed in 19 organ(s), highest expression level in seminiferous tubule of testis
ExpressionAtlasiQ9DAC0 baseline and differential
GenevisibleiQ9DAC0 MM

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLF2B_MOUSE
AccessioniPrimary (citable) accession number: Q9DAC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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