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Protein

Septin-14

Gene

Sept14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113GTP; via amide nitrogenBy similarity1
Binding sitei246GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei261GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi58 – 65GTPBy similarity8
Nucleotide bindingi194 – 202GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-14
Gene namesi
Name:Sept14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921472 Sept14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944261 – 430Septin-14Add BLAST430

Proteomic databases

MaxQBiQ9DA97
PaxDbiQ9DA97
PeptideAtlasiQ9DA97
PRIDEiQ9DA97

PTM databases

iPTMnetiQ9DA97
PhosphoSitePlusiQ9DA97

Expressioni

Gene expression databases

BgeeiENSMUSG00000034219 Expressed in 13 organ(s), highest expression level in testis
CleanExiMM_SEPT14
ExpressionAtlasiQ9DA97 baseline and differential
GenevisibleiQ9DA97 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044272

Structurei

3D structure databases

ProteinModelPortaliQ9DA97
SMRiQ9DA97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 313Septin-type GPROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 65G1 motifPROSITE-ProRule annotation8
Regioni110 – 113G3 motifPROSITE-ProRule annotation4
Regioni193 – 196G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili329 – 410Sequence analysisAdd BLAST82

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ9DA97
KOiK16941
OrthoDBiEOG091G0IKM
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9DA97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKPTNTSV PIPGSEDPQK ENIRCLSTLG HFGFECLPTQ LVNKSIQKGF
60 70 80 90 100
SFNILCVGET GIGKTTLINT LFNTNLKETK SSHFYSKVGL TVKTYELLER
110 120 130 140 150
NIPLRLTVVK TVGYGDQINK EASYQPVVDY LDAQFEAYLQ EELKIKRSLA
160 170 180 190 200
DYHDSRIHVC LYFITPTGHS LKSLDLLTMK SIDRRVNIIP LIAKADSLSK
210 220 230 240 250
NDLQRFKNNI MSELNSNGIQ IYQFQVDDEA SAQVNSSGLL PFAVVGSMEE
260 270 280 290 300
VKVGKRMVRG RHYPWGVLQE VENENHCDFV KLRDLLLSTN MEDLKDQTHT
310 320 330 340 350
QHYECYRSNR LQKLGFSDTG PDNRPVSFQE MYEAKRREFH NQCQKEEEEL
360 370 380 390 400
KQTFMQRVKE KELTFKDAEK ELQDKFEHLK RIQQEEILKL EEERRKLEEQ
410 420 430
IIDFYKMKAA SESAQAQVCT NIKKDKDRKK
Length:430
Mass (Da):49,811
Last modified:April 3, 2013 - v3
Checksum:i769580BADF745878
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2P6S4R2P6_MOUSE
Septin-14
Sept14
429Annotation score:

Sequence cautioni

The sequence BAB24381 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270Missing in BAB24381 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120413 Genomic DNA No translation available.
AK006043 mRNA Translation: BAB24381.1 Sequence problems.
RefSeqiNP_083102.1, NM_028826.1
UniGeneiMm.159143

Genome annotation databases

EnsembliENSMUST00000042266; ENSMUSP00000044272; ENSMUSG00000034219
GeneIDi74222
KEGGimmu:74222

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120413 Genomic DNA No translation available.
AK006043 mRNA Translation: BAB24381.1 Sequence problems.
RefSeqiNP_083102.1, NM_028826.1
UniGeneiMm.159143

3D structure databases

ProteinModelPortaliQ9DA97
SMRiQ9DA97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044272

PTM databases

iPTMnetiQ9DA97
PhosphoSitePlusiQ9DA97

Proteomic databases

MaxQBiQ9DA97
PaxDbiQ9DA97
PeptideAtlasiQ9DA97
PRIDEiQ9DA97

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042266; ENSMUSP00000044272; ENSMUSG00000034219
GeneIDi74222
KEGGimmu:74222

Organism-specific databases

CTDi346288
MGIiMGI:1921472 Sept14

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ9DA97
KOiK16941
OrthoDBiEOG091G0IKM
TreeFamiTF101080

Miscellaneous databases

PROiPR:Q9DA97
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034219 Expressed in 13 organ(s), highest expression level in testis
CleanExiMM_SEPT14
ExpressionAtlasiQ9DA97 baseline and differential
GenevisibleiQ9DA97 MM

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEP14_MOUSE
AccessioniPrimary (citable) accession number: Q9DA97
Secondary accession number(s): E9QMM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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