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Protein

Intraflagellar transport protein 43 homolog

Gene

Ift43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 43 homolog
Gene namesi
Name:Ift43
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1923661 Ift43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002540421 – 206Intraflagellar transport protein 43 homologAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei77PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9DA69

PTM databases

iPTMnetiQ9DA69
PhosphoSitePlusiQ9DA69

Expressioni

Gene expression databases

BgeeiENSMUSG00000007867
CleanExiMM_1700019E19RIK
ExpressionAtlasiQ9DA69 baseline and differential
GenevisibleiQ9DA69 MM

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A) complex. Interacts with WDR35/IFT121 (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the IFT43 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012060
HOVERGENiHBG081288
InParanoidiQ9DA69
KOiK19675
OMAiRKTGWGD
OrthoDBiEOG091G12FE
PhylomeDBiQ9DA69
TreeFamiTF323566

Family and domain databases

InterProiView protein in InterPro
IPR029302 IFT43
PANTHERiPTHR33724 PTHR33724, 1 hit
PfamiView protein in Pfam
PF15305 IFT43, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DA69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLLDLGEE RRRSSATSGA KMGRRAHQES TQAENYLNSK NSSLTQTGEA
60 70 80 90 100
PPPKPPRRQG GWADDSMKMA KLGKKVSEEM EDHRLRQQNL MGSDDDDIPV
110 120 130 140 150
IPDLEDVQEE DFVLQVASPP SIQVNRVMTY RDLDNDLMKY SAFQTLDGEI
160 170 180 190 200
DLKLLTKVLA PEHEVREDDV GWDWDHLYTE VSSELLTEWD LLRAEKEDPV

GPSRYI
Length:206
Mass (Da):23,501
Last modified:October 31, 2006 - v2
Checksum:i318C95F1D108B9FE
GO
Isoform 2 (identifier: Q9DA69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-82: KLGKKVSEEMED → N

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):22,241
Checksum:i13F28081FFF6AD5A
GO
Isoform 3 (identifier: Q9DA69-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MDDLLDLGEERRRSSATS → MLGAG

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):21,897
Checksum:i090C8BA23BAF3511
GO

Sequence cautioni

The sequence AAH38915 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0211701 – 18MDDLL…SSATS → MLGAG in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_02117171 – 82KLGKK…EEMED → N in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006115 mRNA Translation: BAB24415.1
BC034668 mRNA Translation: AAH34668.1
BC038915 mRNA Translation: AAH38915.1 Different initiation.
CCDSiCCDS26064.1 [Q9DA69-2]
RefSeqiNP_001186772.1, NM_001199843.1 [Q9DA69-1]
NP_083877.1, NM_029601.3 [Q9DA69-2]
UniGeneiMm.292345

Genome annotation databases

EnsembliENSMUST00000054565; ENSMUSP00000061891; ENSMUSG00000007867 [Q9DA69-2]
ENSMUST00000222821; ENSMUSP00000152079; ENSMUSG00000007867 [Q9DA69-1]
GeneIDi76411
KEGGimmu:76411
UCSCiuc007oho.2 mouse [Q9DA69-2]
uc007ohp.2 mouse [Q9DA69-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIFT43_MOUSE
AccessioniPrimary (citable) accession number: Q9DA69
Secondary accession number(s): Q8CFI3, Q8K213
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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