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Protein

Protein lifeguard 4

Gene

Tmbim4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 4
Alternative name(s):
Transmembrane BAX inhibitor motif-containing protein 4
Z-protein
Gene namesi
Name:Tmbim4
Synonyms:Lfg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1915462 Tmbim4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 68LumenalSequence analysis9
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 97CytoplasmicSequence analysis8
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 120LumenalSequence analysis2
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 175LumenalSequence analysis3
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 208CytoplasmicSequence analysisAdd BLAST12
Intramembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 238CytoplasmicSequence analysis9

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790931 – 238Protein lifeguard 4Add BLAST238

Proteomic databases

MaxQBiQ9DA39
PaxDbiQ9DA39
PRIDEiQ9DA39

PTM databases

PhosphoSitePlusiQ9DA39

Expressioni

Gene expression databases

BgeeiENSMUSG00000020225 Expressed in 265 organ(s), highest expression level in dorsal pancreas
CleanExiMM_TMBIM4
ExpressionAtlasiQ9DA39 baseline and differential
GenevisibleiQ9DA39 MM

Interactioni

Subunit structurei

Interacts with ITPR3.By similarity

Protein-protein interaction databases

BioGridi212733, 1 interactor
STRINGi10090.ENSMUSP00000020446

Structurei

3D structure databases

ProteinModelPortaliQ9DA39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ9DA39
KOiK06890
OMAiSHNAYAE
OrthoDBiEOG091G0JRK
PhylomeDBiQ9DA39
TreeFamiTF321860

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9DA39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADTDPGYPR SSIEDDFNYG SCVASASVHI RMAFLRKVYS ILSLQVLLTT
60 70 80 90 100
VTSALFLYFQ ALRTFVHESP ALIVVFALGS LGLIFALTLH RHTHPLNLYL
110 120 130 140 150
LFAFTLSESL AVAAVVTFYD VYLVLQAFIM TTAVFLGLTA YTLQSKRDFT
160 170 180 190 200
KFGAGLFAGL WILCLAGFLK LFFYSETMEL VLASLGALLF CGFIIYDTHS
210 220 230
LMHRLSPEEY VIAAISLYMD IINLFLHLLK FLEAVNKK
Length:238
Mass (Da):26,647
Last modified:June 1, 2001 - v1
Checksum:i67F3B6ECA496C9F7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8K191Q8K191_MOUSE
Protein lifeguard 4
Tmbim4
120Annotation score:
D6RIR2D6RIR2_MOUSE
Protein lifeguard 4
Tmbim4
93Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006207 mRNA Translation: BAB24458.1
CCDSiCCDS24205.1
RefSeqiNP_080893.1, NM_026617.3
UniGeneiMm.157426

Genome annotation databases

EnsembliENSMUST00000020446; ENSMUSP00000020446; ENSMUSG00000020225
GeneIDi68212
KEGGimmu:68212
UCSCiuc007hey.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006207 mRNA Translation: BAB24458.1
CCDSiCCDS24205.1
RefSeqiNP_080893.1, NM_026617.3
UniGeneiMm.157426

3D structure databases

ProteinModelPortaliQ9DA39
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212733, 1 interactor
STRINGi10090.ENSMUSP00000020446

PTM databases

PhosphoSitePlusiQ9DA39

Proteomic databases

MaxQBiQ9DA39
PaxDbiQ9DA39
PRIDEiQ9DA39

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020446; ENSMUSP00000020446; ENSMUSG00000020225
GeneIDi68212
KEGGimmu:68212
UCSCiuc007hey.1 mouse

Organism-specific databases

CTDi51643
MGIiMGI:1915462 Tmbim4

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ9DA39
KOiK06890
OMAiSHNAYAE
OrthoDBiEOG091G0JRK
PhylomeDBiQ9DA39
TreeFamiTF321860

Miscellaneous databases

ChiTaRSiTmbim4 mouse
PROiPR:Q9DA39
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020225 Expressed in 265 organ(s), highest expression level in dorsal pancreas
CleanExiMM_TMBIM4
ExpressionAtlasiQ9DA39 baseline and differential
GenevisibleiQ9DA39 MM

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLFG4_MOUSE
AccessioniPrimary (citable) accession number: Q9DA39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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