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Protein

EF-hand domain-containing protein 1

Gene

Efhc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis.By similarity1 Publication

GO - Molecular functioni

  • alpha-tubulin binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing protein 1
Alternative name(s):
Myoclonin-1
Gene namesi
Name:Efhc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919127 Efhc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738781 – 648EF-hand domain-containing protein 1Add BLAST648

Proteomic databases

MaxQBiQ9D9T8
PaxDbiQ9D9T8
PRIDEiQ9D9T8

PTM databases

iPTMnetiQ9D9T8
PhosphoSitePlusiQ9D9T8

Expressioni

Tissue specificityi

Expressed in adult brain including hippocampus, cerebellum, cerebral cortex, thalamus, hypothalamus, amygdala and upper brainstem. Expressed in soma and dentrites of pyramidal neurons of the hippocampal CA1 region, pyramidal neurons of the cerebral cortex and Purkinje cells of cerebellum. Highly expressed in testis, trachea, and oviduct, moderately in lung, and slightly in brain. Highly expressed in sperm flagella and tracheal cilia (at protein level).2 Publications

Gene expression databases

CleanExiMM_EFHC1

Interactioni

Subunit structurei

Interacts with the C-terminus of CACNA1E. InteractS with alpha-tubulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042343

Structurei

3D structure databases

ProteinModelPortaliQ9D9T8
SMRiQ9D9T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 198DM10 1PROSITE-ProRule annotationAdd BLAST106
Domaini239 – 359DM10 2PROSITE-ProRule annotationAdd BLAST121
Domaini416 – 520DM10 3PROSITE-ProRule annotationAdd BLAST105
Domaini582 – 617EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Required for its localization in the mitotic spindle and interaction with alpha-tubulinBy similarityAdd BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0043 Eukaryota
ENOG410XQCQ LUCA
HOGENOMiHOG000265451
HOVERGENiHBG059646
InParanoidiQ9D9T8
PhylomeDBiQ9D9T8

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR010554 DUF1126
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR006602 Uncharacterised_DM10
PfamiView protein in Pfam
PF06565 DUF1126, 3 hits
SMARTiView protein in SMART
SM00676 DM10, 3 hits
SM00054 EFh, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS51336 DM10, 3 hits
PS50222 EF_HAND_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9D9T8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTNPVHGLP FLPGSSFTDS TKTAFHRSQT LNYRNGYAVV RRPTMGIGGD
60 70 80 90 100
RLHYNQLSQA ELDELANKAP ILTYGPLKQA PLAEFVPAHV AFDKKVLKFS
110 120 130 140 150
AYFQEDVPIS MEEHYRIRHV NIYYYLEDDS MSVIEPVVEN SGIPQGKLIK
160 170 180 190 200
RQRFTKNDMG DHYHWKDLNR GINLTVYGKT FRIVDCDRFT QDFLESQGIE
210 220 230 240 250
LNPSEKIPLD PYTQLRKEPV RKYVTPSDFD QLKQFLTFDK QVLRFYAIWD
260 270 280 290 300
DTDSLFGECR HYIIHYYLMD DTVEIREVHE RNNGRDPFPL LMNRQRMPKV
310 320 330 340 350
LVENAKNFPK CVLEISDQEV LEWYTAKDFI VGKPLTILGR TFFIYDCDPF
360 370 380 390 400
TRQFYKDKFG MPDLPPVDVT KKEPPPVKQE LPPYNGYGLI EDSAQNCFAL
410 420 430 440 450
IPKAPRKDVV KMLMNDNKVL RYLAALESPI PEDKDRRFVF SYFLATDMIS
460 470 480 490 500
IFEPPVRNSG IIGGKFLGRT KVVKSFSPVD NPIYYSPSDF FIGAVIEVFG
510 520 530 540 550
HRFVILDTDE YVLKYMESNA SQYSPEALAS IQNRIQKPEL PAPELESKQA
560 570 580 590 600
TGEPMVQGTE ESKVQDLDAL IDQIHMHLKY NSYKENLRET FQMYDKDESG
610 620 630 640
YVDRETFFKI CETLNVPVDD SLIKELIRLC THGEGRINYY NFVRAFSN
Length:648
Mass (Da):75,142
Last modified:June 1, 2001 - v1
Checksum:iBBA3377AADB9D373
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2CKC6B2CKC6_MOUSE
EF-hand domain containing 1
Efhc1
648Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006489 mRNA Translation: BAB24614.1
CCDSiCCDS48227.1
RefSeqiNP_082250.1, NM_027974.1
UniGeneiMm.29178

Genome annotation databases

GeneIDi71877
KEGGimmu:71877

Similar proteinsi

Entry informationi

Entry nameiEFHC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D9T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: January 31, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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