UniProtKB - Q9D9J3 (ACTT1_MOUSE)
Protein
Actin-related protein T1
Gene
Actrt1
Organism
Mus musculus (Mouse)
Status
Functioni
Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.By similarity
GO - Molecular functioni
- chromatin binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- regulation of smoothened signaling pathway Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein T1 |
Gene namesi | Name:Actrt1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920610, Actrt1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Cytoplasm By similarity
Note: Both detected in the nucleus and cytoplasm, localizes to the nucleus where it binds chromatin upon stimulation of the Hedgehog pathway.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000255658 | 1 – 376 | Actin-related protein T1Add BLAST | 376 |
Proteomic databases
PaxDbi | Q9D9J3 |
PRIDEi | Q9D9J3 |
PTM databases
PhosphoSitePlusi | Q9D9J3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000046615, Expressed in spermatid and 7 other tissues |
Genevisiblei | Q9D9J3, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000062570 |
Miscellaneous databases
RNActi | Q9D9J3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the actin family.Curated
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000162451 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | Q9D9J3 |
OMAi | CNHAVGA |
OrthoDBi | 708610at2759 |
PhylomeDBi | Q9D9J3 |
TreeFami | TF354237 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR030139, Arp-T1 IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit PTHR11937:SF153, PTHR11937:SF153, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9D9J3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDPARLDNP AVIFDNGSGL CKVGISGEIE PRHVINSVVG HPKFNIPSAR
60 70 80 90 100
SNRKRYFVGE EAQCMYDGLY LHYPIERGLV TRWDDMEKLW KDLFEWELGV
110 120 130 140 150
KPNEQPVFMT EPSLNPQETR EKTTEIMFEK FNVPALYLCN HAVGALCASA
160 170 180 190 200
CITGLVLDSG DGVTCTVPVY EGYSLPHAIT KLYVAGRDIT EHLTRLLLAK
210 220 230 240 250
GYTFPCILNK AVVDDIKEKL CTVSLGYKDT EKNCQQFLRK YTLPDGNTIQ
260 270 280 290 300
MSDHLCQVPE VLFTPDHLGI HDLGISKMVC NSIMNCDTDI QENLFAEIVL
310 320 330 340 350
SGGTTMFPGL QDRLLKELED LAFEGTPIKI TASSDRCYSA WIGGSVMTSM
360 370
TTFKQMWVTA EDFKEYGAFV VQRKCF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK006855 mRNA Translation: BAB24765.1 BC116431 mRNA Translation: AAI16432.1 BC116432 mRNA Translation: AAI16433.1 |
CCDSi | CCDS30102.1 |
RefSeqi | NP_082790.1, NM_028514.3 |
Genome annotation databases
Ensembli | ENSMUST00000059466; ENSMUSP00000062570; ENSMUSG00000046615 |
GeneIDi | 73360 |
KEGGi | mmu:73360 |
UCSCi | uc009tbj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK006855 mRNA Translation: BAB24765.1 BC116431 mRNA Translation: AAI16432.1 BC116432 mRNA Translation: AAI16433.1 |
CCDSi | CCDS30102.1 |
RefSeqi | NP_082790.1, NM_028514.3 |
3D structure databases
SMRi | Q9D9J3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000062570 |
PTM databases
PhosphoSitePlusi | Q9D9J3 |
Proteomic databases
PaxDbi | Q9D9J3 |
PRIDEi | Q9D9J3 |
Protocols and materials databases
Antibodypediai | 511, 107 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000059466; ENSMUSP00000062570; ENSMUSG00000046615 |
GeneIDi | 73360 |
KEGGi | mmu:73360 |
UCSCi | uc009tbj.1, mouse |
Organism-specific databases
CTDi | 139741 |
MGIi | MGI:1920610, Actrt1 |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000162451 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | Q9D9J3 |
OMAi | CNHAVGA |
OrthoDBi | 708610at2759 |
PhylomeDBi | Q9D9J3 |
TreeFami | TF354237 |
Miscellaneous databases
BioGRID-ORCSi | 73360, 3 hits in 18 CRISPR screens |
PROi | PR:Q9D9J3 |
RNActi | Q9D9J3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046615, Expressed in spermatid and 7 other tissues |
Genevisiblei | Q9D9J3, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR030139, Arp-T1 IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit PTHR11937:SF153, PTHR11937:SF153, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACTT1_MOUSE | |
Accessioni | Q9D9J3Primary (citable) accession number: Q9D9J3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families