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Protein

Transmembrane and coiled-coil domain-containing protein 5A

Gene

Tmco5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 5A
Gene namesi
Name:Tmco5a
Synonyms:Tmco5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914606 Tmco5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei242 – 264HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051541 – 303Transmembrane and coiled-coil domain-containing protein 5AAdd BLAST303

Proteomic databases

PaxDbiQ9D9D5
PRIDEiQ9D9D5

PTM databases

iPTMnetiQ9D9D5
PhosphoSitePlusiQ9D9D5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027355 Expressed in 28 organ(s), highest expression level in testis
CleanExiMM_TMCO5
ExpressionAtlasiQ9D9D5 baseline and differential
GenevisibleiQ9D9D5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028834

Structurei

3D structure databases

ProteinModelPortaliQ9D9D5
SMRiQ9D9D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili25 – 204Sequence analysisAdd BLAST180

Sequence similaritiesi

Belongs to the TMCO5 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCD Eukaryota
ENOG411142W LUCA
GeneTreeiENSGT00390000004036
HOGENOMiHOG000154632
HOVERGENiHBG067207
InParanoidiQ9D9D5
OMAiWKLRCFL
OrthoDBiEOG091G0JAH
PhylomeDBiQ9D9D5
TreeFamiTF337140

Family and domain databases

InterProiView protein in InterPro
IPR026617 SMCO2/5
PANTHERiPTHR22422 PTHR22422, 1 hit
PfamiView protein in Pfam
PF14992 TMCO5, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D9D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEQKENQLD YESEKMEILR LAQSKKNIIS LNMDLERDMQ RIDEANQELL
60 70 80 90 100
LEIQEKENEI QRLEHEITQT GNPAEDEEWE KENYTVMERE QALQELEEET
110 120 130 140 150
ARLERKNETL VHSISELQRK LTRKSQKVIR YEQGDLETTP EESKVKLQQL
160 170 180 190 200
ESSCADQEKE LGKIMEDYVF VSQLCEDQAL CIKKYQEALK RIEEELETGY
210 220 230 240 250
LEREVSKVLS MDSERERSTS LNKMDGFISK GALRFSKSIF RSLLFSTLFF
260 270 280 290 300
IRLLGYLIFH LSFINPDLLV NALPKILSRD VLWKLRCFLF PSLTLETEDM

LPH
Length:303
Mass (Da):35,854
Last modified:June 1, 2001 - v1
Checksum:iD4AA3952B5C10586
GO
Isoform 2 (identifier: Q9D9D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-182: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):33,524
Checksum:i719A8E0D76EAF093
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YLS6Z4YLS6_MOUSE
Transmembrane and coiled-coil domai...
Tmco5
250Annotation score:
A0A0R4J1W9A0A0R4J1W9_MOUSE
Transmembrane and coiled-coil domai...
Tmco5
226Annotation score:

Sequence cautioni

The sequence CAM20932 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM20933 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028248163 – 182Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007078 mRNA Translation: BAB24853.1
AK007251 mRNA Translation: BAB24916.1
AL845318 Genomic DNA Translation: CAM20932.1 Sequence problems.
AL845318 Genomic DNA Translation: CAM20933.1 Sequence problems.
AL845318 Genomic DNA Translation: CAM20934.1
BC049568 mRNA Translation: AAH49568.1
CCDSiCCDS16569.1 [Q9D9D5-1]
RefSeqiNP_080380.1, NM_026104.4 [Q9D9D5-1]
XP_006500140.1, XM_006500077.2
UniGeneiMm.131623
Mm.447273

Genome annotation databases

EnsembliENSMUST00000028834; ENSMUSP00000028834; ENSMUSG00000027355 [Q9D9D5-1]
GeneIDi67356
KEGGimmu:67356
UCSCiuc008lre.2 mouse [Q9D9D5-1]
uc008lrf.2 mouse [Q9D9D5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007078 mRNA Translation: BAB24853.1
AK007251 mRNA Translation: BAB24916.1
AL845318 Genomic DNA Translation: CAM20932.1 Sequence problems.
AL845318 Genomic DNA Translation: CAM20933.1 Sequence problems.
AL845318 Genomic DNA Translation: CAM20934.1
BC049568 mRNA Translation: AAH49568.1
CCDSiCCDS16569.1 [Q9D9D5-1]
RefSeqiNP_080380.1, NM_026104.4 [Q9D9D5-1]
XP_006500140.1, XM_006500077.2
UniGeneiMm.131623
Mm.447273

3D structure databases

ProteinModelPortaliQ9D9D5
SMRiQ9D9D5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028834

PTM databases

iPTMnetiQ9D9D5
PhosphoSitePlusiQ9D9D5

Proteomic databases

PaxDbiQ9D9D5
PRIDEiQ9D9D5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028834; ENSMUSP00000028834; ENSMUSG00000027355 [Q9D9D5-1]
GeneIDi67356
KEGGimmu:67356
UCSCiuc008lre.2 mouse [Q9D9D5-1]
uc008lrf.2 mouse [Q9D9D5-2]

Organism-specific databases

CTDi67356
MGIiMGI:1914606 Tmco5

Phylogenomic databases

eggNOGiENOG410IFCD Eukaryota
ENOG411142W LUCA
GeneTreeiENSGT00390000004036
HOGENOMiHOG000154632
HOVERGENiHBG067207
InParanoidiQ9D9D5
OMAiWKLRCFL
OrthoDBiEOG091G0JAH
PhylomeDBiQ9D9D5
TreeFamiTF337140

Miscellaneous databases

PROiPR:Q9D9D5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027355 Expressed in 28 organ(s), highest expression level in testis
CleanExiMM_TMCO5
ExpressionAtlasiQ9D9D5 baseline and differential
GenevisibleiQ9D9D5 MM

Family and domain databases

InterProiView protein in InterPro
IPR026617 SMCO2/5
PANTHERiPTHR22422 PTHR22422, 1 hit
PfamiView protein in Pfam
PF14992 TMCO5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMC5A_MOUSE
AccessioniPrimary (citable) accession number: Q9D9D5
Secondary accession number(s): A2ARB1, Q9CVN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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