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Protein

Transcriptional and immune response regulator

Gene

Tcim

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (PubMed:24937306). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional and immune response regulator
Gene namesi
Name:TcimImported
Synonyms:Tc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916318 Tcim

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice have increased number of myeloid and lymphoid cells on peripheral blood compared to wild type controls. Red blood cells are small-sized but increased in number. In bone marrow, cells show higher colony forming units.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896061 – 106Transcriptional and immune response regulatorAdd BLAST106

Proteomic databases

MaxQBiQ9D915
PaxDbiQ9D915
PRIDEiQ9D915

PTM databases

iPTMnetiQ9D915
PhosphoSitePlusiQ9D915

Expressioni

Tissue specificityi

Expressed in liver, expression levels decrease in regenerating liver (PubMed:25985737). In bone marrow, expressed in large progenitor-like cells, cells with ring-shaped nuclei and, at lower, levels in hematopietic stem cell-like cells with round nuclei (at protein level) (PubMed:24937306).2 Publications

Gene expression databases

BgeeiENSMUSG00000056313 Expressed in 223 organ(s), highest expression level in parotid gland
CleanExiMM_1810011O10RIK
GenevisibleiQ9D915 MM

Interactioni

Subunit structurei

Monomer. Interacts with NOTCH2 (via ANK repeats), the interaction inhibits the nuclear translocation of NOTCH2 N2ICD. Interacts (C-terminus) with CBY1 (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058631

Structurei

3D structure databases

ProteinModelPortaliQ9D915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXNR Eukaryota
ENOG410YPN0 LUCA
GeneTreeiENSGT00390000003458
HOGENOMiHOG000111608
HOVERGENiHBG054954
InParanoidiQ9D915
OMAiSPSVHGY
OrthoDBiEOG091G0YFM
PhylomeDBiQ9D915
TreeFamiTF338287

Family and domain databases

InterProiView protein in InterPro
IPR020282 Avpi1/C8orf4_dom
IPR039580 Tcim
PANTHERiPTHR32358 PTHR32358, 1 hit
PfamiView protein in Pfam
PF15063 TC1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD287216 Arg_vasopressin-induced_prot_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAKPSHQAT SMSSSLRVSP SIHGYHFDTA ARKKAVGNIF ENIDQESLQR
60 70 80 90 100
LFRNSGDKKA EERAKIIFAI DQDLEEKTRA LMALKKRTKD KLLQFLKLRK

YSIKVH
Length:106
Mass (Da):12,215
Last modified:June 1, 2001 - v1
Checksum:i46D87C0D259DFDB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007441 mRNA Translation: BAB25041.1
BC016562 mRNA Translation: AAH16562.1
CCDSiCCDS22194.1
RefSeqiNP_081207.1, NM_026931.2
UniGeneiMm.25775

Genome annotation databases

EnsembliENSMUST00000052622; ENSMUSP00000058631; ENSMUSG00000056313
GeneIDi69068
KEGGimmu:69068
UCSCiuc009lex.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007441 mRNA Translation: BAB25041.1
BC016562 mRNA Translation: AAH16562.1
CCDSiCCDS22194.1
RefSeqiNP_081207.1, NM_026931.2
UniGeneiMm.25775

3D structure databases

ProteinModelPortaliQ9D915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058631

PTM databases

iPTMnetiQ9D915
PhosphoSitePlusiQ9D915

Proteomic databases

MaxQBiQ9D915
PaxDbiQ9D915
PRIDEiQ9D915

Protocols and materials databases

DNASUi69068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052622; ENSMUSP00000058631; ENSMUSG00000056313
GeneIDi69068
KEGGimmu:69068
UCSCiuc009lex.1 mouse

Organism-specific databases

CTDi56892
MGIiMGI:1916318 Tcim

Phylogenomic databases

eggNOGiENOG410IXNR Eukaryota
ENOG410YPN0 LUCA
GeneTreeiENSGT00390000003458
HOGENOMiHOG000111608
HOVERGENiHBG054954
InParanoidiQ9D915
OMAiSPSVHGY
OrthoDBiEOG091G0YFM
PhylomeDBiQ9D915
TreeFamiTF338287

Miscellaneous databases

PROiPR:Q9D915
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056313 Expressed in 223 organ(s), highest expression level in parotid gland
CleanExiMM_1810011O10RIK
GenevisibleiQ9D915 MM

Family and domain databases

InterProiView protein in InterPro
IPR020282 Avpi1/C8orf4_dom
IPR039580 Tcim
PANTHERiPTHR32358 PTHR32358, 1 hit
PfamiView protein in Pfam
PF15063 TC1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD287216 Arg_vasopressin-induced_prot_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCIM_MOUSE
AccessioniPrimary (citable) accession number: Q9D915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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