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Protein

Probable rRNA-processing protein EBP2

Gene

Ebna1bp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the processing of the 27S pre-rRNA.By similarity

GO - Biological processi

  • ribosomal large subunit biogenesis Source: GO_Central
  • rRNA processing Source: GO_Central

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Probable rRNA-processing protein EBP2
Gene namesi
Name:Ebna1bp2
Synonyms:Ebp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916322 Ebna1bp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199941 – 306Probable rRNA-processing protein EBP2Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphothreonineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Cross-linki93Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei264PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D903
MaxQBiQ9D903
PaxDbiQ9D903
PeptideAtlasiQ9D903
PRIDEiQ9D903

PTM databases

iPTMnetiQ9D903
PhosphoSitePlusiQ9D903

Miscellaneous databases

PMAP-CutDBiQ9D903

Expressioni

Gene expression databases

BgeeiENSMUSG00000028729 Expressed in 289 organ(s), highest expression level in midbrain
CleanExiMM_EBNA1BP2
ExpressionAtlasiQ9D903 baseline and differential
GenevisibleiQ9D903 MM

Interactioni

Subunit structurei

Interacts with WDR46.By similarity

Protein-protein interaction databases

BioGridi213211, 3 interactors
CORUMiQ9D903
DIPiDIP-48579N
IntActiQ9D903, 2 interactors
MINTiQ9D903
STRINGi10090.ENSMUSP00000030501

Structurei

3D structure databases

ProteinModelPortaliQ9D903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 171Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the EBP2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3080 Eukaryota
ENOG410YYHN LUCA
GeneTreeiENSGT00390000014984
HOGENOMiHOG000231281
HOVERGENiHBG031528
InParanoidiQ9D903
KOiK14823
OMAiMFHRQAQ
OrthoDBiEOG091G0HC5
PhylomeDBiQ9D903
TreeFamiTF314642

Family and domain databases

InterProiView protein in InterPro
IPR008610 Ebp2
PANTHERiPTHR13028 PTHR13028, 1 hit
PfamiView protein in Pfam
PF05890 Ebp2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D903-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTPPLSESD SESDACLASD QELQDAFSRG LLKPGLNVVL EKPKKAVNDV
60 70 80 90 100
SGLKQCLAEF RRDLEWVERL DVTLGPVPEV SETQPTPQNQ DQKKGVNPED
110 120 130 140 150
DFQREMSFYR QAQAAVLAVL PRLHQLQVPT KRPTDYFAEM AKSDQQMQKI
160 170 180 190 200
RQKLQTKQAA MEKSEKAKQL RALRKYGKKV QTEVLQKRQR EKAHMMNAIK
210 220 230 240 250
KYQKGFSDKL DFLEGDQKPV ERSAKAGGKG QQMSKGPNAK RRYKNQKFGF
260 270 280 290 300
GGKKKGSKWN TKESYDDVSS FRAKVAHGKG SRRPGKKGAN KRPGKRARQK

LKSKAR
Length:306
Mass (Da):34,703
Last modified:June 1, 2001 - v1
Checksum:iC612FB25A47084EA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ACZ1A2ACZ1_MOUSE
Probable rRNA-processing protein EB...
Ebna1bp2
186Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007491 mRNA Translation: BAB25065.1
AK134732 mRNA Translation: BAE22261.1
AK167070 mRNA Translation: BAE39230.1
AK168269 mRNA Translation: BAE40215.1
AL669952 Genomic DNA No translation available.
BC054723 mRNA Translation: AAH54723.1
BC062876 mRNA Translation: AAH62876.1
CCDSiCCDS18555.1
RefSeqiNP_081208.1, NM_026932.4
UniGeneiMm.29906

Genome annotation databases

EnsembliENSMUST00000030501; ENSMUSP00000030501; ENSMUSG00000028729
GeneIDi69072
KEGGimmu:69072
UCSCiuc008ukn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007491 mRNA Translation: BAB25065.1
AK134732 mRNA Translation: BAE22261.1
AK167070 mRNA Translation: BAE39230.1
AK168269 mRNA Translation: BAE40215.1
AL669952 Genomic DNA No translation available.
BC054723 mRNA Translation: AAH54723.1
BC062876 mRNA Translation: AAH62876.1
CCDSiCCDS18555.1
RefSeqiNP_081208.1, NM_026932.4
UniGeneiMm.29906

3D structure databases

ProteinModelPortaliQ9D903
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213211, 3 interactors
CORUMiQ9D903
DIPiDIP-48579N
IntActiQ9D903, 2 interactors
MINTiQ9D903
STRINGi10090.ENSMUSP00000030501

PTM databases

iPTMnetiQ9D903
PhosphoSitePlusiQ9D903

Proteomic databases

EPDiQ9D903
MaxQBiQ9D903
PaxDbiQ9D903
PeptideAtlasiQ9D903
PRIDEiQ9D903

Protocols and materials databases

DNASUi69072
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030501; ENSMUSP00000030501; ENSMUSG00000028729
GeneIDi69072
KEGGimmu:69072
UCSCiuc008ukn.2 mouse

Organism-specific databases

CTDi10969
MGIiMGI:1916322 Ebna1bp2

Phylogenomic databases

eggNOGiKOG3080 Eukaryota
ENOG410YYHN LUCA
GeneTreeiENSGT00390000014984
HOGENOMiHOG000231281
HOVERGENiHBG031528
InParanoidiQ9D903
KOiK14823
OMAiMFHRQAQ
OrthoDBiEOG091G0HC5
PhylomeDBiQ9D903
TreeFamiTF314642

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PMAP-CutDBiQ9D903
PROiPR:Q9D903
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028729 Expressed in 289 organ(s), highest expression level in midbrain
CleanExiMM_EBNA1BP2
ExpressionAtlasiQ9D903 baseline and differential
GenevisibleiQ9D903 MM

Family and domain databases

InterProiView protein in InterPro
IPR008610 Ebp2
PANTHERiPTHR13028 PTHR13028, 1 hit
PfamiView protein in Pfam
PF05890 Ebp2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9D903
Secondary accession number(s): A2ACZ0, Q3TKB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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