UniProtKB - Q9D903 (EBP2_MOUSE)
Protein
Probable rRNA-processing protein EBP2
Gene
Ebna1bp2
Organism
Mus musculus (Mouse)
Status
Functioni
Required for the processing of the 27S pre-rRNA.By similarity
GO - Biological processi
- ribosomal large subunit biogenesis Source: GO_Central
- rRNA processing Source: GO_Central
Keywordsi
Biological process | Ribosome biogenesis |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Probable rRNA-processing protein EBP2 |
Gene namesi | Name:Ebna1bp2 Synonyms:Ebp2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916322, Ebna1bp2 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- nuclear periphery Source: GO_Central
- nucleolus Source: UniProtKB
Other locations
- preribosome, large subunit precursor Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119994 | 1 – 306 | Probable rRNA-processing protein EBP2Add BLAST | 306 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 3 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 9 | PhosphoserineBy similarity | 1 | |
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Cross-linki | 93 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 179 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 218 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 270 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9D903 |
MaxQBi | Q9D903 |
PaxDbi | Q9D903 |
PeptideAtlasi | Q9D903 |
PRIDEi | Q9D903 |
PTM databases
iPTMneti | Q9D903 |
PhosphoSitePlusi | Q9D903 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028729, Expressed in embryonic post-anal tail and 305 other tissues |
ExpressionAtlasi | Q9D903, baseline and differential |
Genevisiblei | Q9D903, MM |
Interactioni
Subunit structurei
Interacts with WDR46.
By similarityProtein-protein interaction databases
BioGRIDi | 213211, 10 interactors |
CORUMi | Q9D903 |
DIPi | DIP-48579N |
IntActi | Q9D903, 2 interactors |
MINTi | Q9D903 |
STRINGi | 10090.ENSMUSP00000030501 |
Miscellaneous databases
RNActi | Q9D903, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 135 – 171 | Sequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the EBP2 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3080, Eukaryota |
GeneTreei | ENSGT00390000014984 |
HOGENOMi | CLU_036007_1_0_1 |
InParanoidi | Q9D903 |
OMAi | MFHRQAQ |
OrthoDBi | 1154126at2759 |
PhylomeDBi | Q9D903 |
TreeFami | TF314642 |
Family and domain databases
InterProi | View protein in InterPro IPR008610, Ebp2 |
PANTHERi | PTHR13028, PTHR13028, 1 hit |
Pfami | View protein in Pfam PF05890, Ebp2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9D903-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTPPLSESD SESDACLASD QELQDAFSRG LLKPGLNVVL EKPKKAVNDV
60 70 80 90 100
SGLKQCLAEF RRDLEWVERL DVTLGPVPEV SETQPTPQNQ DQKKGVNPED
110 120 130 140 150
DFQREMSFYR QAQAAVLAVL PRLHQLQVPT KRPTDYFAEM AKSDQQMQKI
160 170 180 190 200
RQKLQTKQAA MEKSEKAKQL RALRKYGKKV QTEVLQKRQR EKAHMMNAIK
210 220 230 240 250
KYQKGFSDKL DFLEGDQKPV ERSAKAGGKG QQMSKGPNAK RRYKNQKFGF
260 270 280 290 300
GGKKKGSKWN TKESYDDVSS FRAKVAHGKG SRRPGKKGAN KRPGKRARQK
LKSKAR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2ACZ1 | A2ACZ1_MOUSE | Probable rRNA-processing protein EB... | Ebna1bp2 | 186 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK007491 mRNA Translation: BAB25065.1 AK134732 mRNA Translation: BAE22261.1 AK167070 mRNA Translation: BAE39230.1 AK168269 mRNA Translation: BAE40215.1 AL669952 Genomic DNA No translation available. BC054723 mRNA Translation: AAH54723.1 BC062876 mRNA Translation: AAH62876.1 |
CCDSi | CCDS18555.1 |
RefSeqi | NP_081208.1, NM_026932.4 |
Genome annotation databases
Ensembli | ENSMUST00000030501; ENSMUSP00000030501; ENSMUSG00000028729 |
GeneIDi | 69072 |
KEGGi | mmu:69072 |
UCSCi | uc008ukn.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK007491 mRNA Translation: BAB25065.1 AK134732 mRNA Translation: BAE22261.1 AK167070 mRNA Translation: BAE39230.1 AK168269 mRNA Translation: BAE40215.1 AL669952 Genomic DNA No translation available. BC054723 mRNA Translation: AAH54723.1 BC062876 mRNA Translation: AAH62876.1 |
CCDSi | CCDS18555.1 |
RefSeqi | NP_081208.1, NM_026932.4 |
3D structure databases
SMRi | Q9D903 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 213211, 10 interactors |
CORUMi | Q9D903 |
DIPi | DIP-48579N |
IntActi | Q9D903, 2 interactors |
MINTi | Q9D903 |
STRINGi | 10090.ENSMUSP00000030501 |
PTM databases
iPTMneti | Q9D903 |
PhosphoSitePlusi | Q9D903 |
Proteomic databases
EPDi | Q9D903 |
MaxQBi | Q9D903 |
PaxDbi | Q9D903 |
PeptideAtlasi | Q9D903 |
PRIDEi | Q9D903 |
Protocols and materials databases
Antibodypediai | 18196, 127 antibodies |
DNASUi | 69072 |
Genome annotation databases
Ensembli | ENSMUST00000030501; ENSMUSP00000030501; ENSMUSG00000028729 |
GeneIDi | 69072 |
KEGGi | mmu:69072 |
UCSCi | uc008ukn.2, mouse |
Organism-specific databases
CTDi | 10969 |
MGIi | MGI:1916322, Ebna1bp2 |
Phylogenomic databases
eggNOGi | KOG3080, Eukaryota |
GeneTreei | ENSGT00390000014984 |
HOGENOMi | CLU_036007_1_0_1 |
InParanoidi | Q9D903 |
OMAi | MFHRQAQ |
OrthoDBi | 1154126at2759 |
PhylomeDBi | Q9D903 |
TreeFami | TF314642 |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 69072, 7 hits in 17 CRISPR screens |
ChiTaRSi | Ebna1bp2, mouse |
PROi | PR:Q9D903 |
RNActi | Q9D903, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028729, Expressed in embryonic post-anal tail and 305 other tissues |
ExpressionAtlasi | Q9D903, baseline and differential |
Genevisiblei | Q9D903, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008610, Ebp2 |
PANTHERi | PTHR13028, PTHR13028, 1 hit |
Pfami | View protein in Pfam PF05890, Ebp2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EBP2_MOUSE | |
Accessioni | Q9D903Primary (citable) accession number: Q9D903 Secondary accession number(s): A2ACZ0, Q3TKB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families