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Protein

General transcription factor IIE subunit 2

Gene

Gtf2e2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 147TFIIE betaPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • transcription initiation from RNA polymerase II promoter Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIE subunit 2
Alternative name(s):
Transcription initiation factor IIE subunit beta
Short name:
TFIIE-beta
Gene namesi
Name:Gtf2e2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915403 Gtf2e2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112271 – 292General transcription factor IIE subunit 2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei75N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D902
MaxQBiQ9D902
PaxDbiQ9D902
PeptideAtlasiQ9D902
PRIDEiQ9D902

PTM databases

iPTMnetiQ9D902
PhosphoSitePlusiQ9D902

Expressioni

Gene expression databases

BgeeiENSMUSG00000031585 Expressed in 288 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ9D902 baseline and differential
GenevisibleiQ9D902 MM

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains. Interacts with FACT subunit SUPT16H. Interacts with ATF7IP. Interacts with SND1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EpopQ7TNS82EBI-309435,EBI-16024836

Protein-protein interaction databases

BioGridi212686, 22 interactors
DIPiDIP-49546N
IntActiQ9D902, 16 interactors
MINTiQ9D902
STRINGi10090.ENSMUSP00000126284

Structurei

3D structure databases

ProteinModelPortaliQ9D902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 37Poly-Ser9
Compositional biasi38 – 43Lys-rich (basic)6
Compositional biasi252 – 272Arg/Lys-rich (basic)Add BLAST21

Sequence similaritiesi

Belongs to the TFIIE beta subunit family.Curated

Phylogenomic databases

eggNOGiKOG3095 Eukaryota
COG5174 LUCA
GeneTreeiENSGT00390000011749
HOGENOMiHOG000008149
HOVERGENiHBG009400
InParanoidiQ9D902
KOiK03137
OMAiETYEDNT
OrthoDBiEOG091G0HXJ
PhylomeDBiQ9D902
TreeFamiTF105901

Family and domain databases

CDDicd07977 TFIIE_beta_winged_helix, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016656 TFIIE-bsu
IPR003166 TFIIE_bsu_DNA-bd
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12716 PTHR12716, 1 hit
PfamiView protein in Pfam
PF02186 TFIIE_beta, 1 hit
PIRSFiPIRSF016398 TFIIE-beta, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51351 TFIIE_BETA_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9D902-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPSLLRDRE LFKKRALSTP VVEKRAVPSE SPSSSSSKKK KAKVEHGGSS
60 70 80 90 100
GSKQNSDHNN GSFNLKALSG SSGYKFGVLA KIVNYMKTRH QRGDTHPLTL
110 120 130 140 150
EEILDETQHL DIGLKQKQWL MTEALVNNPK IEVVDGKYAF KPKYNLKDKK
160 170 180 190 200
ALLRLLDNHD QRGLGGILLE DIEEGLPNSQ KAVKALGDQI LFVSRPDKKK
210 220 230 240 250
ILFFNDKSCQ FSVDEEFQKL WRSVTVDSMD EEKIEEYLKR QGISSMQESG
260 270 280 290
PKKVASIQRR KKPASQKKRR FKTHNEHLAG VLKDYSDITP GK
Length:292
Mass (Da):33,047
Last modified:April 26, 2005 - v2
Checksum:i4D74B98C7ACBA60B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSE8A0A087WSE8_MOUSE
General transcription factor IIE su...
Gtf2e2
127Annotation score:
A0A087WSS5A0A087WSS5_MOUSE
General transcription factor IIE su...
Gtf2e2
62Annotation score:
A0A087WQX6A0A087WQX6_MOUSE
General transcription factor IIE su...
Gtf2e2
30Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20P → L in BAB25066 (PubMed:16141072).Curated1
Sequence conflicti80A → S in BAB25066 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007492 mRNA Translation: BAB25066.1
AK088342 mRNA Translation: BAC40294.1
AK150415 mRNA Translation: BAE29539.1
AK153370 mRNA Translation: BAE31938.1
AK158783 mRNA Translation: BAE34662.1
BC020016 mRNA Translation: AAH20016.1
CCDSiCCDS22236.1
RefSeqiNP_001161393.1, NM_001167921.1
NP_001161394.1, NM_001167922.1
NP_080860.3, NM_026584.3
XP_006509249.1, XM_006509186.1
XP_006509250.1, XM_006509187.1
XP_006509251.1, XM_006509188.3
UniGeneiMm.286104

Genome annotation databases

EnsembliENSMUST00000167264; ENSMUSP00000129834; ENSMUSG00000031585
ENSMUST00000170705; ENSMUSP00000126284; ENSMUSG00000031585
ENSMUST00000171010; ENSMUSP00000132287; ENSMUSG00000031585
GeneIDi68153
KEGGimmu:68153
UCSCiuc009lkh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007492 mRNA Translation: BAB25066.1
AK088342 mRNA Translation: BAC40294.1
AK150415 mRNA Translation: BAE29539.1
AK153370 mRNA Translation: BAE31938.1
AK158783 mRNA Translation: BAE34662.1
BC020016 mRNA Translation: AAH20016.1
CCDSiCCDS22236.1
RefSeqiNP_001161393.1, NM_001167921.1
NP_001161394.1, NM_001167922.1
NP_080860.3, NM_026584.3
XP_006509249.1, XM_006509186.1
XP_006509250.1, XM_006509187.1
XP_006509251.1, XM_006509188.3
UniGeneiMm.286104

3D structure databases

ProteinModelPortaliQ9D902
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212686, 22 interactors
DIPiDIP-49546N
IntActiQ9D902, 16 interactors
MINTiQ9D902
STRINGi10090.ENSMUSP00000126284

PTM databases

iPTMnetiQ9D902
PhosphoSitePlusiQ9D902

Proteomic databases

EPDiQ9D902
MaxQBiQ9D902
PaxDbiQ9D902
PeptideAtlasiQ9D902
PRIDEiQ9D902

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167264; ENSMUSP00000129834; ENSMUSG00000031585
ENSMUST00000170705; ENSMUSP00000126284; ENSMUSG00000031585
ENSMUST00000171010; ENSMUSP00000132287; ENSMUSG00000031585
GeneIDi68153
KEGGimmu:68153
UCSCiuc009lkh.2 mouse

Organism-specific databases

CTDi2961
MGIiMGI:1915403 Gtf2e2

Phylogenomic databases

eggNOGiKOG3095 Eukaryota
COG5174 LUCA
GeneTreeiENSGT00390000011749
HOGENOMiHOG000008149
HOVERGENiHBG009400
InParanoidiQ9D902
KOiK03137
OMAiETYEDNT
OrthoDBiEOG091G0HXJ
PhylomeDBiQ9D902
TreeFamiTF105901

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

ChiTaRSiGtf2e2 mouse
PROiPR:Q9D902
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031585 Expressed in 288 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ9D902 baseline and differential
GenevisibleiQ9D902 MM

Family and domain databases

CDDicd07977 TFIIE_beta_winged_helix, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016656 TFIIE-bsu
IPR003166 TFIIE_bsu_DNA-bd
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12716 PTHR12716, 1 hit
PfamiView protein in Pfam
PF02186 TFIIE_beta, 1 hit
PIRSFiPIRSF016398 TFIIE-beta, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51351 TFIIE_BETA_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT2EB_MOUSE
AccessioniPrimary (citable) accession number: Q9D902
Secondary accession number(s): Q3U5Y7, Q8BTZ2, Q8VE14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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