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Protein

EF-hand domain-containing protein D2

Gene

Efhd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi105 – 1161PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi141 – 1522PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing protein D2
Alternative name(s):
Swiprosin-1
Gene namesi
Name:Efhd2
Synonyms:Sws1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106504 Efhd2

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000736462 – 240EF-hand domain-containing protein D2Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei74PhosphoserineCombined sources1
Modified residuei76PhosphoserineBy similarity1
Modified residuei83PhosphotyrosineCombined sources1
Modified residuei233N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D8Y0
MaxQBiQ9D8Y0
PaxDbiQ9D8Y0
PeptideAtlasiQ9D8Y0
PRIDEiQ9D8Y0

2D gel databases

REPRODUCTION-2DPAGEiQ9D8Y0

PTM databases

iPTMnetiQ9D8Y0
PhosphoSitePlusiQ9D8Y0

Expressioni

Tissue specificityi

Detected in thymus, kidney, spleen, lung, liver and brain. Highest abundance in brain and lowest in kidney and thymus.1 Publication

Developmental stagei

Expressed throughout B-cell differentiation, with highest expression in immature bone marrow B-cells.1 Publication

Gene expression databases

CleanExiMM_EFHD2

Interactioni

Subunit structurei

Interacts with CASP9; with inactive form.By similarity

Protein-protein interaction databases

IntActiQ9D8Y0, 3 interactors
STRINGi10090.ENSMUSP00000044502

Structurei

3D structure databases

ProteinModelPortaliQ9D8Y0
SMRiQ9D8Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 127EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0041 Eukaryota
ENOG4111JG9 LUCA
HOGENOMiHOG000007978
HOVERGENiHBG051446
InParanoidiQ9D8Y0
PhylomeDBiQ9D8Y0

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D8Y0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDELASKL SRRLQMEGEG GEATEQPGLN GAAAAAAAEA PDETAQALGS
60 70 80 90 100
ADDELSAKLL RRADLNQGIG EPQSPSRRVF NPYTEFKEFS RKQIKDMEKM
110 120 130 140 150
FKQYDAGRDG FIDLMELKLM MEKLGAPQTH LGLKSMIQEV DEDFDSKLSF
160 170 180 190 200
REFLLIFRKA AAGELQEDSG LQVLARLSEI DVSTEGVKGA KNFFEAKVQA
210 220 230 240
INVSSRFEEE IKAEQEERKK QAEEVKQRKA AFKELQSTFK
Length:240
Mass (Da):26,791
Last modified:June 1, 2001 - v1
Checksum:iF11E549BFCB2C247
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C845Q8C845_MOUSE
EF-hand domain-containing protein D...
Efhd2
240Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14L → V in BAB27476 (PubMed:16141072).Curated1
Sequence conflicti172Q → H in BAB27476 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007560 mRNA Translation: BAB25108.1
AK011219 mRNA Translation: BAB27476.1
CCDSiCCDS18885.1
UniGeneiMm.395598

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007560 mRNA Translation: BAB25108.1
AK011219 mRNA Translation: BAB27476.1
CCDSiCCDS18885.1
UniGeneiMm.395598

3D structure databases

ProteinModelPortaliQ9D8Y0
SMRiQ9D8Y0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D8Y0, 3 interactors
STRINGi10090.ENSMUSP00000044502

PTM databases

iPTMnetiQ9D8Y0
PhosphoSitePlusiQ9D8Y0

2D gel databases

REPRODUCTION-2DPAGEiQ9D8Y0

Proteomic databases

EPDiQ9D8Y0
MaxQBiQ9D8Y0
PaxDbiQ9D8Y0
PeptideAtlasiQ9D8Y0
PRIDEiQ9D8Y0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106504 Efhd2

Phylogenomic databases

eggNOGiKOG0041 Eukaryota
ENOG4111JG9 LUCA
HOGENOMiHOG000007978
HOVERGENiHBG051446
InParanoidiQ9D8Y0
PhylomeDBiQ9D8Y0

Miscellaneous databases

PROiPR:Q9D8Y0
SOURCEiSearch...

Gene expression databases

CleanExiMM_EFHD2

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEFHD2_MOUSE
AccessioniPrimary (citable) accession number: Q9D8Y0
Secondary accession number(s): Q9D0P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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