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Protein

Marginal zone B- and B1-cell-specific protein

Gene

Mzb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion and integrin activation.
Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Marginal zone B- and B1-cell-specific protein
Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name:
Plasma cell-induced resident ER protein
Short name:
pERp1
Proapoptotic caspase adapter protein
Gene namesi
Name:Mzb1
Synonyms:Pacap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1917066 Mzb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49C → A: Reduced electrophoretic mobility; when associated with A-52. 1 Publication1
Mutagenesisi52C → A: Reduced electrophoretic mobility; when associated with A-49. 1 Publication1
Mutagenesisi94C → A: Small loss of electrophoretic mobility. 1 Publication1
Mutagenesisi142C → A: Small loss of electrophoretic mobility. 1 Publication1
Mutagenesisi170C → A: Reduced electrophoretic mobility; when associated with A-177. 1 Publication1
Mutagenesisi177C → A: Reduced electrophoretic mobility; when associated with A-170. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3259485

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000031874121 – 188Marginal zone B- and B1-cell-specific proteinAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 1771 Publication
Disulfide bondi52 ↔ 1701 Publication
Disulfide bondi94 ↔ 1421 Publication

Post-translational modificationi

Forms an interchain disulfide bond with IgM monomers.

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9D8I1
PaxDbiQ9D8I1
PeptideAtlasiQ9D8I1
PRIDEiQ9D8I1

PTM databases

PhosphoSitePlusiQ9D8I1

Expressioni

Tissue specificityi

Expressed predominantly in the spleen and lymph nodes. Abundantly expressed in marginal zone B and B1 cells. High expression in mesenteric adipose tissue (MAT). Expressed also in pancreas, perigonadal adipose tissue (PAT), uterus, subcutaneous adipose tissue, heart, muscle, ovary and liver. Very low expression is detected in brown adipose tissue. In PAT, significantly higher expression in stromal-vascular cell than in adipocytes. Expressed in macrophage RAW 264.7 cell line. Down-regulated in For-knockout female MAT at 5 months (obese state) followed by steep up-regulation at 9 months (prediabetic condition) when mutants progress towards the metabolic syndrome.3 Publications

Developmental stagei

Up-regulated during plasma cell differentiation.2 Publications

Gene expression databases

BgeeiENSMUSG00000024353 Expressed in 66 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_2010001M09RIK
GenevisibleiQ9D8I1 MM

Interactioni

Subunit structurei

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.2 Publications

Protein-protein interaction databases

DIPiDIP-48984N
IntActiQ9D8I1, 1 interactor
STRINGi10090.ENSMUSP00000025211

Structurei

3D structure databases

ProteinModelPortaliQ9D8I1
SMRiQ9D8I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi185 – 188Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the MZB1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J06F Eukaryota
ENOG4111YKY LUCA
GeneTreeiENSGT00390000002716
HOGENOMiHOG000068171
HOVERGENiHBG108230
InParanoidiQ9D8I1
OMAiEKYSAHM
OrthoDBiEOG091G1197
PhylomeDBiQ9D8I1
TreeFamiTF329450

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8I1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPLPLLLL FGCRAILGSA GDRVSLSASA PTLDDEEKYS AHMPAHLRCD
60 70 80 90 100
ACRAVAFQMG QRLAKAEAKS HTPDASGLQE LSESTYTDVL DQTCSQNWQS
110 120 130 140 150
YGVHEVNQMK RLTGPGLSKG PEPRISVMIS GGPWPNRLSK TCFHYLGEFG
160 170 180
EDQIYEAYRQ GQANLEALLC GGTHGPCSQE ILAQREEL
Length:188
Mass (Da):20,580
Last modified:February 26, 2008 - v2
Checksum:i101640BE6E9B0A93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6P → T in BAC40141 (PubMed:16141072).Curated1
Sequence conflicti11F → L in ACY74344 (PubMed:19805157).Curated1
Sequence conflicti11F → L in BAB25410 (PubMed:16141072).Curated1
Sequence conflicti31P → H in ACY74344 (PubMed:19805157).Curated1
Sequence conflicti31P → H in BAB25410 (PubMed:16141072).Curated1
Sequence conflicti136N → S in BAB25410 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ477351 mRNA Translation: ACY74344.1
AK008016 mRNA Translation: BAB25410.1
AK088094 mRNA Translation: BAC40141.1
BC030674 mRNA Translation: AAH30674.1
BC064044 mRNA Translation: AAH64044.1
CCDSiCCDS29145.1
RefSeqiNP_081498.2, NM_027222.3
UniGeneiMm.27252

Genome annotation databases

EnsembliENSMUST00000025211; ENSMUSP00000025211; ENSMUSG00000024353
GeneIDi69816
KEGGimmu:69816
UCSCiuc008emm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ477351 mRNA Translation: ACY74344.1
AK008016 mRNA Translation: BAB25410.1
AK088094 mRNA Translation: BAC40141.1
BC030674 mRNA Translation: AAH30674.1
BC064044 mRNA Translation: AAH64044.1
CCDSiCCDS29145.1
RefSeqiNP_081498.2, NM_027222.3
UniGeneiMm.27252

3D structure databases

ProteinModelPortaliQ9D8I1
SMRiQ9D8I1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48984N
IntActiQ9D8I1, 1 interactor
STRINGi10090.ENSMUSP00000025211

Chemistry databases

ChEMBLiCHEMBL3259485

PTM databases

PhosphoSitePlusiQ9D8I1

Proteomic databases

MaxQBiQ9D8I1
PaxDbiQ9D8I1
PeptideAtlasiQ9D8I1
PRIDEiQ9D8I1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025211; ENSMUSP00000025211; ENSMUSG00000024353
GeneIDi69816
KEGGimmu:69816
UCSCiuc008emm.2 mouse

Organism-specific databases

CTDi51237
MGIiMGI:1917066 Mzb1

Phylogenomic databases

eggNOGiENOG410J06F Eukaryota
ENOG4111YKY LUCA
GeneTreeiENSGT00390000002716
HOGENOMiHOG000068171
HOVERGENiHBG108230
InParanoidiQ9D8I1
OMAiEKYSAHM
OrthoDBiEOG091G1197
PhylomeDBiQ9D8I1
TreeFamiTF329450

Miscellaneous databases

PROiPR:Q9D8I1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024353 Expressed in 66 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_2010001M09RIK
GenevisibleiQ9D8I1 MM

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMZB1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8I1
Secondary accession number(s): D2IYS1
, Q6P3D3, Q8BU13, Q8K2M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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