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Protein

Regenerating islet-derived protein 4

Gene

Reg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).By similarity

GO - Molecular functioni

  • heparin binding Source: MGI
  • mannan binding Source: MGI
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  • response to bacterium Source: MGI

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 4
Short name:
REG-4
Gene namesi
Name:Reg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914959 Reg4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001743823 – 157Regenerating islet-derived protein 4Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 40PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 153PROSITE-ProRule annotation
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 145PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D8G5
PaxDbiQ9D8G5
PeptideAtlasiQ9D8G5
PRIDEiQ9D8G5

PTM databases

iPTMnetiQ9D8G5
PhosphoSitePlusiQ9D8G5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027876 Expressed in 53 organ(s), highest expression level in crypt of Lieberkuhn of small intestine
CleanExiMM_REG4
GenevisibleiQ9D8G5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029469

Structurei

3D structure databases

ProteinModelPortaliQ9D8G5
SMRiQ9D8G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 154C-type lectinPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 102Carbohydrate-bindingBy similarity6
Regioni134 – 136Carbohydrate-bindingBy similarity3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ9D8G5
KOiK22244
OMAiCNKRQHF
OrthoDBiEOG091G0PSR
PhylomeDBiQ9D8G5

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKGVRLLL LLSWVAGPEV LSDILRPSCA PGWFYYRSHC YGYFRKLRNW
60 70 80 90 100
SHAELECQSY GNGSHLASVL NQKEASVISK YITGYQRNLP VWIGLHDPQK
110 120 130 140 150
KQLWQWTDGS TNLYRRWNPR TKSEARHCAE MNPKDKFLTW NKNGCANRQH

FLCKYKT
Length:157
Mass (Da):18,398
Last modified:June 1, 2001 - v1
Checksum:iF3981722BBD83968
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → Y in BAB25669 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008049 mRNA Translation: BAB25429.1
AK008438 mRNA Translation: BAB25669.1
AK162316 mRNA Translation: BAE36851.1
BC019465 mRNA Translation: AAH19465.1
CCDSiCCDS17661.1
RefSeqiNP_080604.2, NM_026328.2
UniGeneiMm.46306

Genome annotation databases

EnsembliENSMUST00000029469; ENSMUSP00000029469; ENSMUSG00000027876
GeneIDi67709
KEGGimmu:67709
UCSCiuc008qpq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008049 mRNA Translation: BAB25429.1
AK008438 mRNA Translation: BAB25669.1
AK162316 mRNA Translation: BAE36851.1
BC019465 mRNA Translation: AAH19465.1
CCDSiCCDS17661.1
RefSeqiNP_080604.2, NM_026328.2
UniGeneiMm.46306

3D structure databases

ProteinModelPortaliQ9D8G5
SMRiQ9D8G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029469

PTM databases

iPTMnetiQ9D8G5
PhosphoSitePlusiQ9D8G5

Proteomic databases

MaxQBiQ9D8G5
PaxDbiQ9D8G5
PeptideAtlasiQ9D8G5
PRIDEiQ9D8G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029469; ENSMUSP00000029469; ENSMUSG00000027876
GeneIDi67709
KEGGimmu:67709
UCSCiuc008qpq.1 mouse

Organism-specific databases

CTDi83998
MGIiMGI:1914959 Reg4

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ9D8G5
KOiK22244
OMAiCNKRQHF
OrthoDBiEOG091G0PSR
PhylomeDBiQ9D8G5

Miscellaneous databases

PROiPR:Q9D8G5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027876 Expressed in 53 organ(s), highest expression level in crypt of Lieberkuhn of small intestine
CleanExiMM_REG4
GenevisibleiQ9D8G5 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG4_MOUSE
AccessioniPrimary (citable) accession number: Q9D8G5
Secondary accession number(s): Q3TS25, Q9D858
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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