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Protein

Tumor necrosis factor receptor superfamily member 13C

Gene

Tnfrsf13c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.1 Publication

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 13C
Alternative name(s):
B-cell maturation defect
B-cell-activating factor receptor
BAFF receptor
Short name:
BAFF-R
BLyS receptor 3
CD_antigen: CD268
Gene namesi
Name:Tnfrsf13c
Synonyms:Baffr, Bcmd, Br3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1919299 Tnfrsf13c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71ExtracellularSequence analysisAdd BLAST71
Transmembranei72 – 92Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini93 – 175CytoplasmicSequence analysisAdd BLAST83

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Tnfrsf13c are a cause of severe B-cell deficiency. B-cell deficient strain A/WySnJ has a 4.7 kb insertion in the BAFFR gene leading to an altered C-terminus. The mutant RNA is not detectable. B-cell lymphopoiesis is normal, but the life span of peripheral B-cells is much reduced.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589341 – 175Tumor necrosis factor receptor superfamily member 13CAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 35By similarity
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi27 ↔ 38By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9D8D0
PRIDEiQ9D8D0

PTM databases

iPTMnetiQ9D8D0
PhosphoSitePlusiQ9D8D0

Expressioni

Tissue specificityi

Highly expressed in spleen and testis; detected at lower levels in lung and thymus.

Gene expression databases

BgeeiENSMUSG00000068105 Expressed in 112 organ(s), highest expression level in blood
ExpressionAtlasiQ9D8D0 baseline and differential
GenevisibleiQ9D8D0 MM

Interactioni

Protein-protein interaction databases

BioGridi215117, 3 interactors
STRINGi10090.ENSMUSP00000086564

Structurei

3D structure databases

ProteinModelPortaliQ9D8D0
SMRiQ9D8D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 38TNFR-Cys; truncatedAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 34Essential for TNFSF13B/TALL1/BAFF/BLyS bindingBy similarity6

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCDG Eukaryota
ENOG41114DK LUCA
GeneTreeiENSGT00390000015844
HOGENOMiHOG000132919
HOVERGENiHBG055867
InParanoidiQ9D8D0
KOiK05151
OMAiAQCFDPL
PhylomeDBiQ9D8D0

Family and domain databases

InterProiView protein in InterPro
IPR022338 TNFR_13C
IPR015336 TNFR_13C_TALL-1-bd
PANTHERiPTHR20437:SF2 PTHR20437:SF2, 1 hit
PfamiView protein in Pfam
PF09256 BaffR-Tall_bind, 1 hit
PRINTSiPR01964 TNFACTORR13C

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D8D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGARRLRVRS QRSRDSSVPT QCNQTECFDP LVRNCVSCEL FHTPDTGHTS
60 70 80 90 100
SLEPGTALQP QEGSALRPDV ALLVGAPALL GLILALTLVG LVSLVSWRWR
110 120 130 140 150
QQLRTASPDT SEGVQQESLE NVFVPSSETP HASAPTWPPL KEDADSALPR
160 170
HSVPVPATEL GSTELVTTKT AGPEQ
Length:175
Mass (Da):18,798
Last modified:June 1, 2001 - v1
Checksum:i28BC7C1A02FB87EF
GO
Isoform 2 (identifier: Q9D8D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-143: Missing.

Show »
Length:164
Mass (Da):17,576
Checksum:iD4B67752267BC706
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U106Q3U106_MOUSE
Tumor necrosis factor receptor supe...
Tnfrsf13c
200Annotation score:
Q3SXS7Q3SXS7_MOUSE
Tnfrsf13c protein
Tnfrsf13c
164Annotation score:
A0A2R8VI78A0A2R8VI78_MOUSE
Tumor necrosis factor receptor supe...
Tnfrsf13c
45Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006506133 – 143Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373847 mRNA Translation: AAK91827.1
AK008142 mRNA Translation: BAB25490.1
CCDSiCCDS27684.1 [Q9D8D0-1]
RefSeqiNP_082351.1, NM_028075.2 [Q9D8D0-1]
UniGeneiMm.240047

Genome annotation databases

EnsembliENSMUST00000089161; ENSMUSP00000086564; ENSMUSG00000068105 [Q9D8D0-1]
GeneIDi72049
KEGGimmu:72049
UCSCiuc007wyj.1 mouse [Q9D8D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373847 mRNA Translation: AAK91827.1
AK008142 mRNA Translation: BAB25490.1
CCDSiCCDS27684.1 [Q9D8D0-1]
RefSeqiNP_082351.1, NM_028075.2 [Q9D8D0-1]
UniGeneiMm.240047

3D structure databases

ProteinModelPortaliQ9D8D0
SMRiQ9D8D0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215117, 3 interactors
STRINGi10090.ENSMUSP00000086564

PTM databases

iPTMnetiQ9D8D0
PhosphoSitePlusiQ9D8D0

Proteomic databases

PaxDbiQ9D8D0
PRIDEiQ9D8D0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089161; ENSMUSP00000086564; ENSMUSG00000068105 [Q9D8D0-1]
GeneIDi72049
KEGGimmu:72049
UCSCiuc007wyj.1 mouse [Q9D8D0-1]

Organism-specific databases

CTDi115650
MGIiMGI:1919299 Tnfrsf13c

Phylogenomic databases

eggNOGiENOG410JCDG Eukaryota
ENOG41114DK LUCA
GeneTreeiENSGT00390000015844
HOGENOMiHOG000132919
HOVERGENiHBG055867
InParanoidiQ9D8D0
KOiK05151
OMAiAQCFDPL
PhylomeDBiQ9D8D0

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Miscellaneous databases

PROiPR:Q9D8D0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068105 Expressed in 112 organ(s), highest expression level in blood
ExpressionAtlasiQ9D8D0 baseline and differential
GenevisibleiQ9D8D0 MM

Family and domain databases

InterProiView protein in InterPro
IPR022338 TNFR_13C
IPR015336 TNFR_13C_TALL-1-bd
PANTHERiPTHR20437:SF2 PTHR20437:SF2, 1 hit
PfamiView protein in Pfam
PF09256 BaffR-Tall_bind, 1 hit
PRINTSiPR01964 TNFACTORR13C
ProtoNetiSearch...

Entry informationi

Entry nameiTR13C_MOUSE
AccessioniPrimary (citable) accession number: Q9D8D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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