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Protein

Mediator of RNA polymerase II transcription subunit 11

Gene

Med11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11
Alternative name(s):
Mediator complex subunit 11
Gene namesi
Name:Med11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913422 Med11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003043092 – 117Mediator of RNA polymerase II transcription subunit 11Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D8C6
MaxQBiQ9D8C6
PaxDbiQ9D8C6
PeptideAtlasiQ9D8C6
PRIDEiQ9D8C6

PTM databases

PhosphoSitePlusiQ9D8C6

Expressioni

Gene expression databases

BgeeiENSMUSG00000018923 Expressed in 278 organ(s), highest expression level in striatum
ExpressionAtlasiQ9D8C6 baseline and differential
GenevisibleiQ9D8C6 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

ComplexPortaliCPX-3264 Core mediator complex
IntActiQ9D8C6, 11 interactors
MINTiQ9D8C6
STRINGi10090.ENSMUSP00000019067

Structurei

3D structure databases

SMRiQ9D8C6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 11 family.Curated

Phylogenomic databases

eggNOGiKOG4057 Eukaryota
ENOG4111SCB LUCA
GeneTreeiENSGT00390000010184
HOGENOMiHOG000006725
HOVERGENiHBG108126
InParanoidiQ9D8C6
KOiK15131
PhylomeDBiQ9D8C6
TreeFamiTF318328

Family and domain databases

InterProiView protein in InterPro
IPR019404 Mediator_Med11
PANTHERiPTHR22890 PTHR22890, 1 hit
PfamiView protein in Pfam
PF10280 Med11, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D8C6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYSLANER LRALEDIERE IGAILQNAGT AILELSKEKT NERLLDRQAA
60 70 80 90 100
AFTTSVQHVE AELSAQIRYL TQVATGQPHE GSSYSSRKDC QMALKRVDYA
110
RLKISDVART CEQMLEN
Length:117
Mass (Da):13,131
Last modified:June 1, 2001 - v1
Checksum:i4A1DD1F73619267D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZ31G3UZ31_MOUSE
Mediator of RNA polymerase II trans...
Med11 MED11
127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108A → V in BAE43156 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003984 mRNA Translation: BAE43156.1
AK008153 mRNA Translation: BAB25497.1
AL596096 Genomic DNA Translation: CAI51988.1
CR936841 Genomic DNA Translation: CAM28187.1
BC025057 mRNA Translation: AAH25057.1
CCDSiCCDS24947.1
RefSeqiNP_079673.2, NM_025397.2
UniGeneiMm.46424

Genome annotation databases

EnsembliENSMUST00000019067; ENSMUSP00000019067; ENSMUSG00000018923
GeneIDi66172
KEGGimmu:66172
UCSCiuc007juv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003984 mRNA Translation: BAE43156.1
AK008153 mRNA Translation: BAB25497.1
AL596096 Genomic DNA Translation: CAI51988.1
CR936841 Genomic DNA Translation: CAM28187.1
BC025057 mRNA Translation: AAH25057.1
CCDSiCCDS24947.1
RefSeqiNP_079673.2, NM_025397.2
UniGeneiMm.46424

3D structure databases

SMRiQ9D8C6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3264 Core mediator complex
IntActiQ9D8C6, 11 interactors
MINTiQ9D8C6
STRINGi10090.ENSMUSP00000019067

PTM databases

PhosphoSitePlusiQ9D8C6

Proteomic databases

EPDiQ9D8C6
MaxQBiQ9D8C6
PaxDbiQ9D8C6
PeptideAtlasiQ9D8C6
PRIDEiQ9D8C6

Protocols and materials databases

DNASUi66172
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019067; ENSMUSP00000019067; ENSMUSG00000018923
GeneIDi66172
KEGGimmu:66172
UCSCiuc007juv.1 mouse

Organism-specific databases

CTDi400569
MGIiMGI:1913422 Med11

Phylogenomic databases

eggNOGiKOG4057 Eukaryota
ENOG4111SCB LUCA
GeneTreeiENSGT00390000010184
HOGENOMiHOG000006725
HOVERGENiHBG108126
InParanoidiQ9D8C6
KOiK15131
PhylomeDBiQ9D8C6
TreeFamiTF318328

Miscellaneous databases

PROiPR:Q9D8C6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018923 Expressed in 278 organ(s), highest expression level in striatum
ExpressionAtlasiQ9D8C6 baseline and differential
GenevisibleiQ9D8C6 MM

Family and domain databases

InterProiView protein in InterPro
IPR019404 Mediator_Med11
PANTHERiPTHR22890 PTHR22890, 1 hit
PfamiView protein in Pfam
PF10280 Med11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED11_MOUSE
AccessioniPrimary (citable) accession number: Q9D8C6
Secondary accession number(s): Q3V4D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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