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UniProtKB - Q9D8C3 (ALG13_MOUSE)

Entry version 132 (23 Feb 2022)
Sequence version 2 (15 Jun 2010)
Previous versions | rss
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Protein

Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13

Gene

Alg13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities.

May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway (By. similarity).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei233For deubiquitinase activityBy similarity1
Active sitei236Nucleophile; for deubiquitinase activityBy similarity1
Active sitei339For deubiquitinase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT1, Glycosyltransferase Family 1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (EC:2.4.1.141, EC:3.4.19.12)
Alternative name(s):
Asparagine-linked glycosylation 13 homolog
Glycosyltransferase 28 domain-containing protein 1
UDP-N-acetylglucosamine transferase subunit ALG13 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Alg13
Synonyms:Glt28d1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1914824, Alg13

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000041718

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002545741 – 1166Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13Add BLAST1166

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9D8C3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9D8C3

PeptideAtlas

More...PeptideAtlasi		Q9D8C3

PRoteomics IDEntifications database

More...PRIDEi		Q9D8C3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		296093 [Q9D8C3-1]
296094 [Q9D8C3-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9D8C3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000041718, Expressed in embryonic stem cell and 276 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9D8C3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9D8C3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2 may interact with ALG14.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		212284, 3 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9D8C3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9D8C3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini225 – 346OTUPROSITE-ProRule annotationAdd BLAST122
Domaini486 – 546TudorPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 125Glycosyltransferase activityBy similarityAdd BLAST125
Regioni126 – 394Deubiquitinase activityBy similarityAdd BLAST269
Regioni393 – 438DisorderedSequence analysisAdd BLAST46
Regioni921 – 966DisorderedSequence analysisAdd BLAST46
Regioni998 – 1056DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi413 – 437Polar residuesSequence analysisAdd BLAST25
Compositional biasi939 – 960Pro residuesSequence analysisAdd BLAST22
Compositional biasi1002 – 1030Pro residuesSequence analysisAdd BLAST29
Compositional biasi1031 – 1056Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 28 family.Curated

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159922

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_085408_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9D8C3

Identification of Orthologs from Complete Genome Data

More...OMAi		EGTYEPK

Database of Orthologous Groups

More...OrthoDBi		222767at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9D8C3

TreeFam database of animal gene trees

More...TreeFami		TF313788

Family and domain databases

Conserved Domains Database

More...CDDi		cd04508, TUDOR, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007235, Glyco_trans_28_C
IPR003323, OTU_dom
IPR038765, Papain-like_cys_pep_sf
IPR002999, Tudor

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04101, Glyco_tran_28_C, 1 hit
PF02338, OTU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50802, OTU, 1 hit
PS50304, TUDOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D8C3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRAFVTVGT TSFDELVARV VANDCVQILE SLGYNHLVLQ VGRGTVVPKP 
        60         70         80         90        100
FRTESFTLDV YRYKDSLKED LQQADLVISH AGAGSCLESL EKGKPLVVVV 
       110        120        130        140        150
NEKLMNNHQF ELAKQLHKEG HLFYCTCRVL SCPAPVSLLL VLLGSAKILQ 
       160        170        180        190        200
QLPSATLSCF GYLPTQAPVL VATAYSYLHS VFSSFPPLST FLIIPCTMQK 
       210        220        230        240        250
GWKKYCGQKS LNEASMDEYL GSLGLFRKVV AKDASCLFRA ISEQLFHSQI 
       260        270        280        290        300
HHLQIRRACV SYMKENQQAF ESYVEGSFEK YLERLGDPKE SAGQLELKAL 
       310        320        330        340        350
SLIYNRDFII YRYPGKPPTQ VTDNGFEDKI ILCYSNNGHY DSVYSKEFQS 
       360        370        380        390        400
TAGICQAILY ELLYKDVFVV DEETLKTAVD LFRSGSRRNK HHALTASVEG 
       410        420        430        440        450
SSDQKSSTED RTEEAAACSS AASTPEGNKQ GTERQKVPES PSKMLFPYKV 
       460        470        480        490        500
LKALDPEIYR NVEFDAWLDS RKELQKSECV EYGGRYYFLG DKCQVCMESG 
       510        520        530        540        550
GKYYNAHIQE IDNDKSSVVV FIEEFAERHS IPLAHVRPVN QVALLPSWNA 
       560        570        580        590        600
IPIRNGRGYP TITGGYFPEI VMTDMNMKQR KKMFKKFRGK EIYMTMAYSR 
       610        620        630        640        650
GDPLVPSRIQ HSMHYGHDPL LYYSQTAGHI LSSQHFYPQH SSQRQGRGYG 
       660        670        680        690        700
MPRDSSHLIS KQNLPNPKVG FCSGSGRKCC QSYDNVSYRS RSFRRSHRQM 
       710        720        730        740        750
HCMNKGCQYG FAPENGVEET VTFYALEEGN ETAYSTLPNN GGPTTMVPAT 
       760        770        780        790        800
SGYCVARQGY NSCKPPLNSG DSNDHCDNGG YHGDYLYSSE QGYETSSVYT 
       810        820        830        840        850
TTVSTANLSL QDSGPSSVPQ DTVTSYNYPQ KVLENSAAIA VSWASHVPVP 
       860        870        880        890        900
VIPNCAGDNE ALRTSDISSQ NAIQPGFVPP PAQGSPAYLE PSAAGAAGAA 
       910        920        930        940        950
AAAAAAAAPV ATPVAAPLPL PPPLPPPPPA TLEAGDASGF PLPPPPPPPP 
       960        970        980        990       1000
PPPPPYSYDP SGSDLPQDTK VLQYYFNLGL QCYHHNYWHP MVYMPHVQQQ 
      1010       1020       1030       1040       1050
LQPQPQPQPQ PQPQPQPQPQ PQPQQPQQQQ PPPQQQQQQQ EQVHGESYPD 
      1060       1070       1080       1090       1100
CTEQPLVDQS APQVYSDVVR EDGTQADVST NDTFPIADAV PLPHGAVYYP 
      1110       1120       1130       1140       1150
VMTDPYGSPL LGFDSYVPVA SDYSSIAMWH PVNAACGASA QIHGAMNPGP 
      1160 
IGYMLLPNSP HYTPQN
Length:1,166
Mass (Da):128,664
Last modified:June 15, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F045ACF188BBE8A
GO
Isoform 2 (identifier: Q9D8C3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-165: RVLSCPAPVS...TLSCFGYLPT → STLPGLLQSM...FLDKVVGLQK
     166-1166: Missing.

Show »
Length:165
Mass (Da):18,346
Checksum:i947DFE404D54FA8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PX10E9PX10_MOUSE
N-acetylglucosaminyldiphosphodolich...
Alg13
155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPZ7A0A5F8MPZ7_MOUSE
Ubiquitinyl hydrolase 1
Alg13
969Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2P6E9Q2P6_MOUSE
N-acetylglucosaminyldiphosphodolich...
Alg13
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q161E9Q161_MOUSE
N-acetylglucosaminyldiphosphodolich...
Alg13
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFD0A0A0G2JFD0_MOUSE
Putative bifunctional UDP-N-acetylg...
Alg13
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEZ0A0A0G2JEZ0_MOUSE
Putative bifunctional UDP-N-acetylg...
Alg13
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM45938 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM45939 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q9D8C3-2)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149Q → H in BAB29554 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039304128 – 165RVLSC…GYLPT → STLPGLLQSMDLSTLKCYPP GQPEKFSAFLDKVVGLQK in isoform 2. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_039305166 – 1166Missing in isoform 2. 2 PublicationsAdd BLAST1001

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK008162 mRNA Translation: BAB25504.1
AK014790 mRNA Translation: BAB29554.1
AK086546 mRNA Translation: BAC39689.1
AK089102 mRNA Translation: BAC40750.1
AL713978 Genomic DNA Translation: CAM45936.1
AL713978 Genomic DNA Translation: CAM45938.1 Sequence problems.
AL713978 Genomic DNA Translation: CAM45939.1 Sequence problems.
CH466610 Genomic DNA Translation: EDL14725.1
BC053004 mRNA No translation available.
BC137692 mRNA Translation: AAI37693.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30456.1 [Q9D8C3-2]

NCBI Reference Sequences

More...RefSeqi		NP_080523.2, NM_026247.3 [Q9D8C3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000070801; ENSMUSP00000068403; ENSMUSG00000041718 [Q9D8C3-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:67574

UCSC genome browser

More...UCSCi		uc009ums.2, mouse [Q9D8C3-2]
uc009umu.2, mouse [Q9D8C3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008162 mRNA Translation: BAB25504.1
AK014790 mRNA Translation: BAB29554.1
AK086546 mRNA Translation: BAC39689.1
AK089102 mRNA Translation: BAC40750.1
AL713978 Genomic DNA Translation: CAM45936.1
AL713978 Genomic DNA Translation: CAM45938.1 Sequence problems.
AL713978 Genomic DNA Translation: CAM45939.1 Sequence problems.
CH466610 Genomic DNA Translation: EDL14725.1
BC053004 mRNA No translation available.
BC137692 mRNA Translation: AAI37693.1
CCDSiCCDS30456.1 [Q9D8C3-2]
RefSeqiNP_080523.2, NM_026247.3 [Q9D8C3-2]

3D structure databases

SMRiQ9D8C3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi212284, 3 interactors

Protein family/group databases

CAZyiGT1, Glycosyltransferase Family 1

PTM databases

PhosphoSitePlusiQ9D8C3

Proteomic databases

jPOSTiQ9D8C3
MaxQBiQ9D8C3
PeptideAtlasiQ9D8C3
PRIDEiQ9D8C3
ProteomicsDBi296093 [Q9D8C3-1]
296094 [Q9D8C3-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9D8C3, 1 sequenced antibody

The DNASU plasmid repository

More...DNASUi		67574

Genome annotation databases

EnsembliENSMUST00000070801; ENSMUSP00000068403; ENSMUSG00000041718 [Q9D8C3-2]
GeneIDi67574
KEGGimmu:67574
UCSCiuc009ums.2, mouse [Q9D8C3-2]
uc009umu.2, mouse [Q9D8C3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79868
MGIiMGI:1914824, Alg13
VEuPathDBiHostDB:ENSMUSG00000041718

Phylogenomic databases

GeneTreeiENSGT00940000159922
HOGENOMiCLU_085408_2_2_1
InParanoidiQ9D8C3
OMAiEGTYEPK
OrthoDBi222767at2759
PhylomeDBiQ9D8C3
TreeFamiTF313788

Enzyme and pathway databases

ReactomeiR-MMU-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		67574, 7 hits in 67 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Alg13, mouse

Protein Ontology

More...PROi		PR:Q9D8C3
RNActiQ9D8C3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000041718, Expressed in embryonic stem cell and 276 other tissues
ExpressionAtlasiQ9D8C3, baseline and differential
GenevisibleiQ9D8C3, MM

Family and domain databases

CDDicd04508, TUDOR, 1 hit
InterProiView protein in InterPro
IPR007235, Glyco_trans_28_C
IPR003323, OTU_dom
IPR038765, Papain-like_cys_pep_sf
IPR002999, Tudor
PfamiView protein in Pfam
PF04101, Glyco_tran_28_C, 1 hit
PF02338, OTU, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802, OTU, 1 hit
PS50304, TUDOR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALG13_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9D8C3
Secondary accession number(s): A3KGC8
, A3KGD0, A3KGD1, Q8BUA4, Q9D5Z6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 15, 2010
Last modified: February 23, 2022
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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