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Protein

Tetraspanin-13

Gene

Tspan13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium channel regulator activity Source: MGI

GO - Biological processi

Protein family/group databases

TCDBi8.A.40.1.8 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Transmembrane 4 superfamily member 13
Gene namesi
Name:Tspan13
Synonyms:Tm4sf13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913359 Tspan13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 44ExtracellularSequence analysis4
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 167ExtracellularSequence analysisAdd BLAST74
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 204CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192591 – 204Tetraspanin-13Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi137N-linked (GlcNAc...) asparagineBy similarity1
Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9D8C2
MaxQBiQ9D8C2
PaxDbiQ9D8C2
PRIDEiQ9D8C2

PTM databases

iPTMnetiQ9D8C2
PhosphoSitePlusiQ9D8C2
SwissPalmiQ9D8C2

Expressioni

Gene expression databases

BgeeiENSMUSG00000020577 Expressed in 307 organ(s), highest expression level in habenula
CleanExiMM_TSPAN13
ExpressionAtlasiQ9D8C2 baseline and differential
GenevisibleiQ9D8C2 MM

Structurei

3D structure databases

ProteinModelPortaliQ9D8C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00500000044851
HOGENOMiHOG000005650
HOVERGENiHBG009195
InParanoidiQ9D8C2
KOiK17356
OMAiTEFVGVW
OrthoDBiEOG091G0PBF
PhylomeDBiQ9D8C2
TreeFamiTF323367

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D8C2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
REQQGQLLEV GWNNTASARN DIQRNLNCCG FRSYNPNDTC PASCAKSTQK
160 170 180 190 200
CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,219
Last modified:June 1, 2001 - v1
Checksum:i76B95421EBCAE5F0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJ37A0A1Y7VJ37_MOUSE
Tetraspanin-13
Tspan13
133Annotation score:
A0A1Y7VK38A0A1Y7VK38_MOUSE
Tetraspanin-13
Tspan13
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97L → S in BAC41170 (PubMed:16141072).Curated1
Sequence conflicti157I → M in BAC41170 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008175 mRNA Translation: BAB25510.1
AK090217 mRNA Translation: BAC41139.1
AK090322 mRNA Translation: BAC41170.1
AK158761 mRNA Translation: BAE34648.1
AK165768 mRNA Translation: BAE38371.1
AK167495 mRNA Translation: BAE39572.1
AK167979 mRNA Translation: BAE39971.1
CT030196 Genomic DNA No translation available.
BC018317 mRNA Translation: AAH18317.1
CCDSiCCDS25882.1
RefSeqiNP_079635.1, NM_025359.3
UniGeneiMm.254663

Genome annotation databases

EnsembliENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577
GeneIDi66109
KEGGimmu:66109
UCSCiuc007njn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008175 mRNA Translation: BAB25510.1
AK090217 mRNA Translation: BAC41139.1
AK090322 mRNA Translation: BAC41170.1
AK158761 mRNA Translation: BAE34648.1
AK165768 mRNA Translation: BAE38371.1
AK167495 mRNA Translation: BAE39572.1
AK167979 mRNA Translation: BAE39971.1
CT030196 Genomic DNA No translation available.
BC018317 mRNA Translation: AAH18317.1
CCDSiCCDS25882.1
RefSeqiNP_079635.1, NM_025359.3
UniGeneiMm.254663

3D structure databases

ProteinModelPortaliQ9D8C2
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.A.40.1.8 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiQ9D8C2
PhosphoSitePlusiQ9D8C2
SwissPalmiQ9D8C2

Proteomic databases

EPDiQ9D8C2
MaxQBiQ9D8C2
PaxDbiQ9D8C2
PRIDEiQ9D8C2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577
GeneIDi66109
KEGGimmu:66109
UCSCiuc007njn.1 mouse

Organism-specific databases

CTDi27075
MGIiMGI:1913359 Tspan13

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00500000044851
HOGENOMiHOG000005650
HOVERGENiHBG009195
InParanoidiQ9D8C2
KOiK17356
OMAiTEFVGVW
OrthoDBiEOG091G0PBF
PhylomeDBiQ9D8C2
TreeFamiTF323367

Miscellaneous databases

PROiPR:Q9D8C2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020577 Expressed in 307 organ(s), highest expression level in habenula
CleanExiMM_TSPAN13
ExpressionAtlasiQ9D8C2 baseline and differential
GenevisibleiQ9D8C2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN13_MOUSE
AccessioniPrimary (citable) accession number: Q9D8C2
Secondary accession number(s): A7NSH9, Q3TMS0, Q8BTH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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