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Protein

Androgen-induced gene 1 protein

Gene

Aig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in androgen-regulated growth of hair follicles.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Androgen-induced gene 1 protein
Short name:
AIG-1
Gene namesi
Name:Aig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913503 Aig1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900991 – 262Androgen-induced gene 1 proteinAdd BLAST262

Proteomic databases

PaxDbiQ9D8B1
PRIDEiQ9D8B1

PTM databases

PhosphoSitePlusiQ9D8B1
SwissPalmiQ9D8B1

Expressioni

Inductioni

By dihydrotestosterone (DHT).By similarity

Gene expression databases

BgeeiENSMUSG00000019806 Expressed in 263 organ(s), highest expression level in oocyte
CleanExiMM_AIG1
ExpressionAtlasiQ9D8B1 baseline and differential
GenevisibleiQ9D8B1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019942

Structurei

3D structure databases

SMRiQ9D8B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3989 Eukaryota
ENOG4111HQA LUCA
GeneTreeiENSGT00390000012526
HOGENOMiHOG000006895
HOVERGENiHBG050468
InParanoidiQ9D8B1
OMAiHTNIVIF
OrthoDBiEOG091G0LUO
PhylomeDBiQ9D8B1
TreeFamiTF318170

Family and domain databases

InterProiView protein in InterPro
IPR006838 Far-17a_AIG1
PANTHERiPTHR10989 PTHR10989, 1 hit
PfamiView protein in Pfam
PF04750 Far-17a_AIG1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D8B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVPCQVLR VAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ
60 70 80 90 100
AVFFGICVLT DLSSLLTRGS GNQEQERQLR KLISLRDWTL AVLAFPVGVF
110 120 130 140 150
VVAVFWTIYA YDREMIYPRL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH
160 170 180 190 200
QYPSRSSGLA AICTFSVGYI LWVCWIHHVT GMWVYPFLEH IGSGARIIFF
210 220 230 240 250
GSTTILMNFL YLLGEVLNSY IWDTQRTKAP SCQDTQSSLS CAKPVQNLCK
260
DTFMLEGGKA RA
Length:262
Mass (Da):29,754
Last modified:June 1, 2001 - v1
Checksum:iDD73482C7A758EA4
GO
Isoform 2 (identifier: Q9D8B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-238: TKAPSCQDTQSS → SIEEEKEKPKLE
     239-262: Missing.

Show »
Length:238
Mass (Da):27,397
Checksum:i23BAE63F35E0CF05
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BX91H7BX91_MOUSE
Androgen-induced gene 1 protein
Aig1
180Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134H → N in BAB23957 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012319227 – 238TKAPS…DTQSS → SIEEEKEKPKLE in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_012320239 – 262Missing in isoform 2. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005332 mRNA Translation: BAB23957.1
AK008210 mRNA Translation: BAB25534.1
BC035305 mRNA Translation: AAH35305.1
CCDSiCCDS23703.1 [Q9D8B1-1]
CCDS83682.1 [Q9D8B1-2]
RefSeqiNP_001334291.1, NM_001347362.1 [Q9D8B1-2]
NP_079722.1, NM_025446.4 [Q9D8B1-1]
UniGeneiMm.45755

Genome annotation databases

EnsembliENSMUST00000019942; ENSMUSP00000019942; ENSMUSG00000019806 [Q9D8B1-1]
ENSMUST00000162610; ENSMUSP00000125366; ENSMUSG00000019806 [Q9D8B1-2]
GeneIDi66253
KEGGimmu:66253
UCSCiuc007elc.1 mouse [Q9D8B1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005332 mRNA Translation: BAB23957.1
AK008210 mRNA Translation: BAB25534.1
BC035305 mRNA Translation: AAH35305.1
CCDSiCCDS23703.1 [Q9D8B1-1]
CCDS83682.1 [Q9D8B1-2]
RefSeqiNP_001334291.1, NM_001347362.1 [Q9D8B1-2]
NP_079722.1, NM_025446.4 [Q9D8B1-1]
UniGeneiMm.45755

3D structure databases

SMRiQ9D8B1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019942

PTM databases

PhosphoSitePlusiQ9D8B1
SwissPalmiQ9D8B1

Proteomic databases

PaxDbiQ9D8B1
PRIDEiQ9D8B1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019942; ENSMUSP00000019942; ENSMUSG00000019806 [Q9D8B1-1]
ENSMUST00000162610; ENSMUSP00000125366; ENSMUSG00000019806 [Q9D8B1-2]
GeneIDi66253
KEGGimmu:66253
UCSCiuc007elc.1 mouse [Q9D8B1-1]

Organism-specific databases

CTDi51390
MGIiMGI:1913503 Aig1

Phylogenomic databases

eggNOGiKOG3989 Eukaryota
ENOG4111HQA LUCA
GeneTreeiENSGT00390000012526
HOGENOMiHOG000006895
HOVERGENiHBG050468
InParanoidiQ9D8B1
OMAiHTNIVIF
OrthoDBiEOG091G0LUO
PhylomeDBiQ9D8B1
TreeFamiTF318170

Miscellaneous databases

ChiTaRSiAig1 mouse
PROiPR:Q9D8B1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019806 Expressed in 263 organ(s), highest expression level in oocyte
CleanExiMM_AIG1
ExpressionAtlasiQ9D8B1 baseline and differential
GenevisibleiQ9D8B1 MM

Family and domain databases

InterProiView protein in InterPro
IPR006838 Far-17a_AIG1
PANTHERiPTHR10989 PTHR10989, 1 hit
PfamiView protein in Pfam
PF04750 Far-17a_AIG1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8B1
Secondary accession number(s): Q8CI90, Q9CW23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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