Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DnaJ homolog subfamily B member 4

Gene

Dnajb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).By similarity

GO - Molecular functioni

  • ATPase activator activity Source: UniProtKB
  • chaperone binding Source: MGI
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 4
Gene namesi
Name:Dnajb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914285 Dnajb4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710221 – 337DnaJ homolog subfamily B member 4Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D832
MaxQBiQ9D832
PaxDbiQ9D832
PeptideAtlasiQ9D832
PRIDEiQ9D832

PTM databases

iPTMnetiQ9D832
PhosphoSitePlusiQ9D832

Expressioni

Gene expression databases

BgeeiENSMUSG00000028035 Expressed in 286 organ(s), highest expression level in secondary oocyte
CleanExiMM_DNAJB4
ExpressionAtlasiQ9D832 baseline and differential
GenevisibleiQ9D832 MM

Interactioni

Subunit structurei

Homodimer. The C-terminal section interacts with the C-terminal tail of OPRM1. Interacts also with SDIM1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D832, 3 interactors
MINTiQ9D832
STRINGi10090.ENSMUSP00000029669

Structurei

3D structure databases

ProteinModelPortaliQ9D832
SMRiQ9D832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 68JPROSITE-ProRule annotationAdd BLAST65

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00760000118947
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiQ9D832
KOiK09510
OMAiMDGRTIP
OrthoDBiEOG091G0DLS
PhylomeDBiQ9D832
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D832-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKDYYHILG IDKGATDEDV KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE
60 70 80 90 100
AYEVLSDPKK REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA
110 120 130 140 150
FFGGSNPFEI FFGRRMGGGR DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG
160 170 180 190 200
PSRLKQDPPI IHELKVSLEE IYSGCTKRMK ISRKRLNPDG RSYRSEDKIL
210 220 230 240 250
TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFVIKDKEH PKFKRDGSNI
260 270 280 290 300
VYTAKISLRE ALCGCSLNVP TMDGRNLPMS VTDIVKPGMR RRVIGYGLPF
310 320 330
PKNPDQRGDL LIEFDVSFPD VISAASKEIL RKHLPAS
Length:337
Mass (Da):37,782
Last modified:June 1, 2001 - v1
Checksum:iBEE4A0E25BCEEFF4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEM9A0A0G2JEM9_MOUSE
DnaJ homolog subfamily B member 4
Dnajb4
8Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66Q → L in BAB24608 (PubMed:16141072).Curated1
Sequence conflicti151P → T in BAB24608 (PubMed:16141072).Curated1
Sequence conflicti329I → S in BAB24608 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006478 mRNA Translation: BAB24608.1
AK008537 mRNA Translation: BAB25729.1
AK028049 mRNA Translation: BAC25720.1
AK136240 mRNA Translation: BAE22891.1
AK162194 mRNA Translation: BAE36783.1
BC017161 mRNA Translation: AAH17161.1
CCDSiCCDS17915.1
RefSeqiNP_080202.1, NM_025926.4
NP_081563.2, NM_027287.4
XP_006501983.1, XM_006501920.3
UniGeneiMm.458538
Mm.46746

Genome annotation databases

EnsembliENSMUST00000029669; ENSMUSP00000029669; ENSMUSG00000028035
ENSMUST00000050073; ENSMUSP00000053916; ENSMUSG00000028035
ENSMUST00000144950; ENSMUSP00000114356; ENSMUSG00000028035
GeneIDi67035
KEGGimmu:67035
UCSCiuc008rsq.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006478 mRNA Translation: BAB24608.1
AK008537 mRNA Translation: BAB25729.1
AK028049 mRNA Translation: BAC25720.1
AK136240 mRNA Translation: BAE22891.1
AK162194 mRNA Translation: BAE36783.1
BC017161 mRNA Translation: AAH17161.1
CCDSiCCDS17915.1
RefSeqiNP_080202.1, NM_025926.4
NP_081563.2, NM_027287.4
XP_006501983.1, XM_006501920.3
UniGeneiMm.458538
Mm.46746

3D structure databases

ProteinModelPortaliQ9D832
SMRiQ9D832
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D832, 3 interactors
MINTiQ9D832
STRINGi10090.ENSMUSP00000029669

PTM databases

iPTMnetiQ9D832
PhosphoSitePlusiQ9D832

Proteomic databases

EPDiQ9D832
MaxQBiQ9D832
PaxDbiQ9D832
PeptideAtlasiQ9D832
PRIDEiQ9D832

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029669; ENSMUSP00000029669; ENSMUSG00000028035
ENSMUST00000050073; ENSMUSP00000053916; ENSMUSG00000028035
ENSMUST00000144950; ENSMUSP00000114356; ENSMUSG00000028035
GeneIDi67035
KEGGimmu:67035
UCSCiuc008rsq.3 mouse

Organism-specific databases

CTDi11080
MGIiMGI:1914285 Dnajb4

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00760000118947
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiQ9D832
KOiK09510
OMAiMDGRTIP
OrthoDBiEOG091G0DLS
PhylomeDBiQ9D832
TreeFamiTF105141

Miscellaneous databases

PROiPR:Q9D832
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028035 Expressed in 286 organ(s), highest expression level in secondary oocyte
CleanExiMM_DNAJB4
ExpressionAtlasiQ9D832 baseline and differential
GenevisibleiQ9D832 MM

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNJB4_MOUSE
AccessioniPrimary (citable) accession number: Q9D832
Secondary accession number(s): Q3TS92, Q9D9U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again