Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inorganic pyrophosphatase

Gene

Ppa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi116Magnesium 1By similarity1
Metal bindingi121Magnesium 1By similarity1
Metal bindingi121Magnesium 2By similarity1
Metal bindingi153Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • phosphate-containing compound metabolic process Source: MGI

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-379716 Cytosolic tRNA aminoacylation
R-MMU-71737 Pyrophosphate hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:Ppa1
Synonyms:Pp, Pyp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97831 Ppa1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001375692 – 289Inorganic pyrophosphataseAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1
Modified residuei228N6-acetyllysineBy similarity1
Modified residuei250PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D819
MaxQBiQ9D819
PaxDbiQ9D819
PRIDEiQ9D819

2D gel databases

REPRODUCTION-2DPAGEiIPI00110684
Q9D819

PTM databases

iPTMnetiQ9D819
PhosphoSitePlusiQ9D819
SwissPalmiQ9D819

Expressioni

Gene expression databases

BgeeiENSMUSG00000020089
CleanExiMM_PPA1
ExpressionAtlasiQ9D819 baseline and differential
GenevisibleiQ9D819 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi212519, 1 interactor
IntActiQ9D819, 4 interactors
MINTiQ9D819
STRINGi10090.ENSMUSP00000020286

Structurei

3D structure databases

ProteinModelPortaliQ9D819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiKOG1626 Eukaryota
COG0221 LUCA
GeneTreeiENSGT00390000017004
HOGENOMiHOG000195569
HOVERGENiHBG000491
InParanoidiQ9D819
KOiK01507
OMAiDGGEINC
OrthoDBiEOG091G0KFV
PhylomeDBiQ9D819
TreeFamiTF300887

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFSSEERA APFTLEYRVF LKNEKGQYIS PFHDVPIYAD KDVFHMVVEV
60 70 80 90 100
PRWSNAKMEI ATKDPLNPIK QDVKKGKLRY VANLFPYKGY IWNYGAIPQT
110 120 130 140 150
WEDPGHSDKH TGCCGDNDPI DVCEIGSKVC ARGEIIRVKV LGILAMIDEG
160 170 180 190 200
ETDWKVIAIN VDDPDAANYK DISDVERLKP GYLEATVDWF RRYKVPDGKP
210 220 230 240 250
ENEFAFNAEF KNKDFAVDII KSTHDYWKAL VTKKTDGKGI SCMNTTVSES
260 270 280
PFKCDPDAAK AIVDALPPPC ESACSLPTDV DKWFHQQKN
Length:289
Mass (Da):32,667
Last modified:June 1, 2001 - v1
Checksum:i4E2D35387CCFED8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008575 mRNA Translation: BAB25754.1
BC010468 mRNA Translation: AAH10468.1
CCDSiCCDS23882.1
RefSeqiNP_080714.2, NM_026438.4
UniGeneiMm.28897

Genome annotation databases

EnsembliENSMUST00000020286; ENSMUSP00000020286; ENSMUSG00000020089
GeneIDi67895
KEGGimmu:67895
UCSCiuc007fge.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIPYR_MOUSE
AccessioniPrimary (citable) accession number: Q9D819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health