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Protein

Cytochrome P450 2C55

Gene

Cyp2c55

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid mainly to 19-hydroxyeicosatetraenoic acid (HETE).1 Publication

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981 Xenobiotics

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C55 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIIC55
Gene namesi
Name:Cyp2c55Imported
Synonyms:Cyp2c-55By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1919332 Cyp2c55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829591 – 490Cytochrome P450 2C55Add BLAST490

Proteomic databases

MaxQBiQ9D816
PaxDbiQ9D816
PeptideAtlasiQ9D816
PRIDEiQ9D816

PTM databases

iPTMnetiQ9D816
PhosphoSitePlusiQ9D816

Expressioni

Tissue specificityi

Highest level in colon. Low levels in liver and small intestine.1 Publication

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiENSMUSG00000025002 Expressed in 30 organ(s), highest expression level in large intestine
GenevisibleiQ9D816 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025966

Structurei

3D structure databases

ProteinModelPortaliQ9D816
SMRiQ9D816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00930000151023
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ9D816
KOiK07413
OMAiRICAGTR
OrthoDBiEOG091G0BT8
PhylomeDBiQ9D816
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D816-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPVLVLVLT LSCLLLLSLW RQNSGRGKLP PGPTPFPIIG NILQIDIKNI
60 70 80 90 100
SKSFNYFSKV YGPVFTLYFG SKPTVVVHGY EAVKEALDDL GEEFSGRGSF
110 120 130 140 150
QIFERINNDL GVIFSNGTKW KELRRFSIMT LRSFGMGKRS IEDRIQEEAS
160 170 180 190 200
CLVEELRKAN GSLCDPTFIL SCAPSNVICS VIFHNRFDYK DEKFLNLMER
210 220 230 240 250
LNENFKILNS PWMQVYNALP TLINYLPGSH NKVIKNFTEI KSYILGRVKE
260 270 280 290 300
HQETLDMDNP RDFIDCFLIK MEQEKHNPHS EFTIESLMAT VTDIFVAGTE
310 320 330 340 350
TTNITLRYGL LLLLKHTEVT AKVQAEIDHV IGRHRSPCMQ DRTRMPYTDA
360 370 380 390 400
MVHEIQRYID LIPNNVPHAA TCNVRFRSYF IPKGTELVTS LTSVLHDDKE
410 420 430 440 450
FPNPEVFDPG HFLDENGNFK KSDYFMPFSI GKRMCVGEAL ARTELFLILT
460 470 480 490
TILQNFNLKS LVDTKDIDTT PVANTFGRVP PSYQLYFIPR
Length:490
Mass (Da):56,096
Last modified:June 1, 2001 - v1
Checksum:i5CB0F771C0268FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY206875 mRNA Translation: AAO52738.1
AK008580 mRNA Translation: BAB25759.1
BC010824 mRNA Translation: AAH10824.1
CCDSiCCDS29790.1
RefSeqiNP_082365.1, NM_028089.3
UniGeneiMm.142581

Genome annotation databases

EnsembliENSMUST00000025966; ENSMUSP00000025966; ENSMUSG00000025002
GeneIDi72082
KEGGimmu:72082
UCSCiuc008hju.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY206875 mRNA Translation: AAO52738.1
AK008580 mRNA Translation: BAB25759.1
BC010824 mRNA Translation: AAH10824.1
CCDSiCCDS29790.1
RefSeqiNP_082365.1, NM_028089.3
UniGeneiMm.142581

3D structure databases

ProteinModelPortaliQ9D816
SMRiQ9D816
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025966

PTM databases

iPTMnetiQ9D816
PhosphoSitePlusiQ9D816

Proteomic databases

MaxQBiQ9D816
PaxDbiQ9D816
PeptideAtlasiQ9D816
PRIDEiQ9D816

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025966; ENSMUSP00000025966; ENSMUSG00000025002
GeneIDi72082
KEGGimmu:72082
UCSCiuc008hju.1 mouse

Organism-specific databases

CTDi72082
MGIiMGI:1919332 Cyp2c55

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00930000151023
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ9D816
KOiK07413
OMAiRICAGTR
OrthoDBiEOG091G0BT8
PhylomeDBiQ9D816
TreeFamiTF352043

Enzyme and pathway databases

ReactomeiR-MMU-211981 Xenobiotics

Miscellaneous databases

PROiPR:Q9D816
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025002 Expressed in 30 organ(s), highest expression level in large intestine
GenevisibleiQ9D816 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP255_MOUSE
AccessioniPrimary (citable) accession number: Q9D816
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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