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Protein

Potassium voltage-gated channel subfamily E member 2

Gene

Kcne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current (By similarity). Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Protein family/group databases

TCDBi8.A.10.2.1 the slow voltage-gated k+) channel accessory protein (mink) family

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 2
Alternative name(s):
MinK-related peptide 1
Minimum potassium ion channel-related peptide 1
Potassium channel subunit beta MiRP1
Gene namesi
Name:Kcne2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891123 Kcne2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 123CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442861 – 123Potassium voltage-gated channel subfamily E member 2Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D808
PRIDEiQ9D808

PTM databases

iPTMnetiQ9D808
PhosphoSitePlusiQ9D808

Interactioni

Subunit structurei

Interacts with KCNB1. Associates with KCNH2/ERG1. May associate with KCNQ2 and KCNQ3. Associates with HCN1 and probably HCN2. Heteromultimer with KCNC2. Interacts with KCNC2 (By similarity). Interacts with KCNQ1; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3197 Voltage-gated potassium channel complex variant 2
STRINGi10090.ENSMUSP00000048849

Structurei

3D structure databases

ProteinModelPortaliQ9D808
SMRiQ9D808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX4Y Eukaryota
ENOG411297Y LUCA
HOGENOMiHOG000113208
HOVERGENiHBG052227
InParanoidiQ9D808
KOiK04896
PhylomeDBiQ9D808
TreeFamiTF336058

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
IPR005425 K_chnl_volt-dep_bsu_KCNE2
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR01605 KCNE2CHANNEL

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D808-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLANLTQT LEDAFKKIFI TYMDSWRRNT TAEEQALQAR VDAENFYYVI
60 70 80 90 100
LYLMVMIGMF SFIVVAILVS TVKSKRREHS QHPYHQYIVE DWQEKYKSQI
110 120
LHLEDSKATI HENMGATGFT VSP
Length:123
Mass (Da):14,370
Last modified:November 28, 2002 - v2
Checksum:i0A52784967FD741C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1J2A0A0R4J1J2_MOUSE
Potassium voltage-gated channel sub...
Kcne2 mCG_49059
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82H → D in BAB25781 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008619 mRNA Translation: BAB25781.1
BC022699 mRNA Translation: AAH22699.1
CCDSiCCDS28333.1
RefSeqiNP_598871.1, NM_134110.3
XP_006523096.1, XM_006523033.3
UniGeneiMm.156736

Genome annotation databases

GeneIDi246133
KEGGimmu:246133
UCSCiuc007zyw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008619 mRNA Translation: BAB25781.1
BC022699 mRNA Translation: AAH22699.1
CCDSiCCDS28333.1
RefSeqiNP_598871.1, NM_134110.3
XP_006523096.1, XM_006523033.3
UniGeneiMm.156736

3D structure databases

ProteinModelPortaliQ9D808
SMRiQ9D808
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3197 Voltage-gated potassium channel complex variant 2
STRINGi10090.ENSMUSP00000048849

Protein family/group databases

TCDBi8.A.10.2.1 the slow voltage-gated k+) channel accessory protein (mink) family

PTM databases

iPTMnetiQ9D808
PhosphoSitePlusiQ9D808

Proteomic databases

PaxDbiQ9D808
PRIDEiQ9D808

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246133
KEGGimmu:246133
UCSCiuc007zyw.2 mouse

Organism-specific databases

CTDi9992
MGIiMGI:1891123 Kcne2

Phylogenomic databases

eggNOGiENOG410IX4Y Eukaryota
ENOG411297Y LUCA
HOGENOMiHOG000113208
HOVERGENiHBG052227
InParanoidiQ9D808
KOiK04896
PhylomeDBiQ9D808
TreeFamiTF336058

Miscellaneous databases

PROiPR:Q9D808
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
IPR005425 K_chnl_volt-dep_bsu_KCNE2
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR01605 KCNE2CHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE2_MOUSE
AccessioniPrimary (citable) accession number: Q9D808
Secondary accession number(s): Q8R1Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: June 20, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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