Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein SLX4IP

Gene

Slx4ip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SLX4IP
Alternative name(s):
SLX4-interacting protein
Gene namesi
Name:Slx4ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921493 Slx4ip

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061201 – 413Protein SLX4IPAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki344Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei389PhosphothreonineBy similarity1
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9D7Y9
PeptideAtlasiQ9D7Y9
PRIDEiQ9D7Y9

PTM databases

iPTMnetiQ9D7Y9
PhosphoSitePlusiQ9D7Y9

Expressioni

Gene expression databases

BgeeiENSMUSG00000027281 Expressed in 165 organ(s), highest expression level in embryo
CleanExiMM_2210009G21RIK
ExpressionAtlasiQ9D7Y9 baseline and differential
GenevisibleiQ9D7Y9 MM

Interactioni

Subunit structurei

Interacts with SLX4/BTBD12; subunit of different structure-specific endonucleases.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096914

Structurei

3D structure databases

ProteinModelPortaliQ9D7Y9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLX4IP family.Curated

Phylogenomic databases

eggNOGiENOG410IK12 Eukaryota
ENOG4111ZEV LUCA
GeneTreeiENSGT00390000016400
HOGENOMiHOG000112024
HOVERGENiHBG094893
InParanoidiQ9D7Y9
OMAiQKRRNCS
OrthoDBiEOG091G07FA
PhylomeDBiQ9D7Y9
TreeFamiTF330769

Family and domain databases

InterProiView protein in InterPro
IPR031479 SLX4IP
PANTHERiPTHR28557 PTHR28557, 1 hit
PfamiView protein in Pfam
PF15744 UPF0492, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9D7Y9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKKFAVKC GNFAVLVDLH VLPQGSNRDS SWFSEQKKEE VCLLLKETID
60 70 80 90 100
SRVKEYVGIY KQRKPSSAEF TRSSPLSLKG YGFQITAYFL KRGIHLHCIQ
110 120 130 140 150
NSQNTELRVF PERFVVCVSQ LAFGHDIWAN QNEKSTKKAL HGVSDYFPEC
160 170 180 190 200
AESSPSPGTK LKRNALKEIV RRTKSKGTDV SKPQPSGDLV GRSSDSVITV
210 220 230 240 250
VPWRRDASAI LLSESVGQAQ DDIRAAKSHQ ELPVQKLENV SQTQPGDTRS
260 270 280 290 300
QQQLHPGEWL KTGLLSRSPA YNYESASPGP KQSLRAAKTQ QKHRNCGSVE
310 320 330 340 350
DCDHRRRVSL GNEGLVPEDA DRERSTAVRV LPALELSDPG LLLKQDLAKA
360 370 380 390 400
KAKEELHALE NLSSRHLVTN NPGQAQQSDS AAITEQLATD QGGPSKKRKK
410
LQSYNRGCSG KKN
Length:413
Mass (Da):45,736
Last modified:June 1, 2001 - v1
Checksum:iEC51E234CF65D2F3
GO
Isoform 2 (identifier: Q9D7Y9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-135: EVCLLLKETI...DIWANQNEKS → VMAFRSQLISSREGYTFTVSRTPRIL

Note: No experimental confirmation available.
Show »
Length:343
Mass (Da):37,657
Checksum:iB0293D3BB10D6CEC
GO
Isoform 3 (identifier: Q9D7Y9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-125: EVCLLLKETI...VCVSQLAFGH → VMAFRSQLIS...LLVQSSRGTL
     126-413: Missing.

Show »
Length:125
Mass (Da):14,486
Checksum:i5C2264DB5C8EC4FD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AHF0A2AHF0_MOUSE
Protein SLX4IP
Slx4ip 2210009G21Rik
55Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02842140 – 135EVCLL…QNEKS → VMAFRSQLISSREGYTFTVS RTPRIL in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_02842240 – 125EVCLL…LAFGH → VMAFRSQLISSREGYTFTVS RTPRILNFVYFLKDLWCVLV SLHLVMIFGQTRMKNRQKKP SMECLIIFLSVQRVHRLLVQ SSRGTL in isoform 3. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_028423126 – 413Missing in isoform 3. 1 PublicationAdd BLAST288

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008687 mRNA Translation: BAB25833.1
AK010392 mRNA Translation: BAB26906.1
AK136226 mRNA Translation: BAE22883.1
AL713981, AL731706 Genomic DNA Translation: CAM16363.1
AL731706, AL713981 Genomic DNA Translation: CAM17285.1
BC067037 mRNA Translation: AAH67037.1
BC071202 mRNA Translation: AAH71202.1
CCDSiCCDS16795.1 [Q9D7Y9-1]
CCDS16796.1 [Q9D7Y9-2]
RefSeqiNP_001033730.1, NM_001038641.1 [Q9D7Y9-1]
NP_082477.1, NM_028201.2 [Q9D7Y9-2]
NP_083110.1, NM_028834.2 [Q9D7Y9-1]
XP_006500353.1, XM_006500290.3 [Q9D7Y9-2]
XP_006500356.1, XM_006500293.3
XP_011238113.1, XM_011239811.1 [Q9D7Y9-1]
UniGeneiMm.330612

Genome annotation databases

EnsembliENSMUST00000028737; ENSMUSP00000028737; ENSMUSG00000027281 [Q9D7Y9-2]
ENSMUST00000099311; ENSMUSP00000096914; ENSMUSG00000027281 [Q9D7Y9-1]
ENSMUST00000180277; ENSMUSP00000136131; ENSMUSG00000027281 [Q9D7Y9-1]
GeneIDi74243
KEGGimmu:74243
UCSCiuc008mou.1 mouse [Q9D7Y9-2]
uc008mov.1 mouse [Q9D7Y9-3]
uc008mow.1 mouse [Q9D7Y9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008687 mRNA Translation: BAB25833.1
AK010392 mRNA Translation: BAB26906.1
AK136226 mRNA Translation: BAE22883.1
AL713981, AL731706 Genomic DNA Translation: CAM16363.1
AL731706, AL713981 Genomic DNA Translation: CAM17285.1
BC067037 mRNA Translation: AAH67037.1
BC071202 mRNA Translation: AAH71202.1
CCDSiCCDS16795.1 [Q9D7Y9-1]
CCDS16796.1 [Q9D7Y9-2]
RefSeqiNP_001033730.1, NM_001038641.1 [Q9D7Y9-1]
NP_082477.1, NM_028201.2 [Q9D7Y9-2]
NP_083110.1, NM_028834.2 [Q9D7Y9-1]
XP_006500353.1, XM_006500290.3 [Q9D7Y9-2]
XP_006500356.1, XM_006500293.3
XP_011238113.1, XM_011239811.1 [Q9D7Y9-1]
UniGeneiMm.330612

3D structure databases

ProteinModelPortaliQ9D7Y9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096914

PTM databases

iPTMnetiQ9D7Y9
PhosphoSitePlusiQ9D7Y9

Proteomic databases

PaxDbiQ9D7Y9
PeptideAtlasiQ9D7Y9
PRIDEiQ9D7Y9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028737; ENSMUSP00000028737; ENSMUSG00000027281 [Q9D7Y9-2]
ENSMUST00000099311; ENSMUSP00000096914; ENSMUSG00000027281 [Q9D7Y9-1]
ENSMUST00000180277; ENSMUSP00000136131; ENSMUSG00000027281 [Q9D7Y9-1]
GeneIDi74243
KEGGimmu:74243
UCSCiuc008mou.1 mouse [Q9D7Y9-2]
uc008mov.1 mouse [Q9D7Y9-3]
uc008mow.1 mouse [Q9D7Y9-1]

Organism-specific databases

CTDi128710
MGIiMGI:1921493 Slx4ip

Phylogenomic databases

eggNOGiENOG410IK12 Eukaryota
ENOG4111ZEV LUCA
GeneTreeiENSGT00390000016400
HOGENOMiHOG000112024
HOVERGENiHBG094893
InParanoidiQ9D7Y9
OMAiQKRRNCS
OrthoDBiEOG091G07FA
PhylomeDBiQ9D7Y9
TreeFamiTF330769

Miscellaneous databases

PROiPR:Q9D7Y9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027281 Expressed in 165 organ(s), highest expression level in embryo
CleanExiMM_2210009G21RIK
ExpressionAtlasiQ9D7Y9 baseline and differential
GenevisibleiQ9D7Y9 MM

Family and domain databases

InterProiView protein in InterPro
IPR031479 SLX4IP
PANTHERiPTHR28557 PTHR28557, 1 hit
PfamiView protein in Pfam
PF15744 UPF0492, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLX4I_MOUSE
AccessioniPrimary (citable) accession number: Q9D7Y9
Secondary accession number(s): Q6NXK0, Q9CWT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again