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Protein

N-acylethanolamine-hydrolyzing acid amidase

Gene

Naaa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Degrades bioactive fatty acid amides to their corresponding acids, with a preference for N-palmitoylethanolamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.5.1.4 3474
ReactomeiR-MMU-112310 Neurotransmitter release cycle

Protein family/group databases

MEROPSiC89.002

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylethanolamine-hydrolyzing acid amidase (EC:3.5.1.-)
Alternative name(s):
N-acylsphingosine amidohydrolase-like
Short name:
ASAH-like protein
Cleaved into the following 2 chains:
Gene namesi
Name:Naaa
Synonyms:Asahl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914361 Naaa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
ChainiPRO_000000231934 – 362N-acylethanolamine-hydrolyzing acid amidaseAdd BLAST329
ChainiPRO_000041965234 – 130N-acylethanolamine-hydrolyzing acid amidase subunit alphaAdd BLAST97
ChainiPRO_0000419653131 – 349N-acylethanolamine-hydrolyzing acid amidase subunit betaAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Autoproteolytic cleavage in the acidic lumen of the lysosome activates the enzyme.By similarity

Keywords - PTMi

Autocatalytic cleavage, Glycoprotein, Zymogen

Proteomic databases

EPDiQ9D7V9
MaxQBiQ9D7V9
PaxDbiQ9D7V9
PRIDEiQ9D7V9

Expressioni

Gene expression databases

BgeeiENSMUSG00000029413 Expressed in 218 organ(s), highest expression level in ventricular system choroidal fissure
ExpressionAtlasiQ9D7V9 baseline and differential
GenevisibleiQ9D7V9 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit, non-covalently linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D7V9, 2 interactors
MINTiQ9D7V9
STRINGi10090.ENSMUSP00000108726

Structurei

3D structure databases

ProteinModelPortaliQ9D7V9
SMRiQ9D7V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid ceramidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJHJ Eukaryota
ENOG4111HJY LUCA
GeneTreeiENSGT00530000063548
HOGENOMiHOG000007253
HOVERGENiHBG050586
InParanoidiQ9D7V9
KOiK13720
OMAiYESTAFC
OrthoDBiEOG091G0E3H
PhylomeDBiQ9D7V9
TreeFamiTF313219

Family and domain databases

InterProiView protein in InterPro
IPR016699 Acid_ceramidase-like
IPR029130 Acid_ceramidase_N
IPR029132 CBAH/NAAA_C
PfamiView protein in Pfam
PF02275 CBAH, 1 hit
PF15508 NAAA-beta, 1 hit
PIRSFiPIRSF017632 Acid_ceramidase-like, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D7V9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTLATRAAC HGAHLALALL LLLSLSGPWL SAVVPGTPPL FNVSLDAAPE
60 70 80 90 100
QRWLPMLRHY DPDFLRTAVA QVIGDRVPQW VLGMVGEIVS KVESFLPQPF
110 120 130 140 150
TDEIRSICDS LNLSLADGIL VNLAYEASAF CTSIVAQDSQ GHIYHGRNLD
160 170 180 190 200
YPFGKILRKL TANVQFIKNG QIAFTGTTFV GYVGLWTGQS PHKFTISGDE
210 220 230 240 250
RDKGWWWENM IAALSLGHSP ISWLIRKTLS ESESFEAAVY TLAKTPLIAD
260 270 280 290 300
VYYIVGGTSP KEGVVITRDR GGPADIWPLD PLNGEWFRVE TNYDHWKPAP
310 320 330 340 350
KVDDRRTPAI KALNATGQAH LNLETLFQVL SLFPVYNNYT IYTTVMSAAE
360
PDKYLTMIRN PS
Length:362
Mass (Da):40,075
Last modified:June 21, 2005 - v2
Checksum:i49480CCA1630699F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XA18G3XA18_MOUSE
N-acylethanolamine-hydrolyzing acid...
Naaa Asahl, mCG_120408
360Annotation score:
H3BL13H3BL13_MOUSE
N-acylethanolamine-hydrolyzing acid...
Naaa
217Annotation score:

Sequence cautioni

The sequence BAB29350 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → D in BAB25888 (PubMed:16141072).Curated1
Sequence conflicti47A → V in AAH04572 (PubMed:15489334).Curated1
Sequence conflicti142H → R in AAH04572 (PubMed:15489334).Curated1
Sequence conflicti163N → D in AAH04572 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162194 mRNA Translation: BAD88530.1
AK008776 mRNA Translation: BAB25888.1
AK014438 mRNA Translation: BAB29350.2 Sequence problems.
BC004572 mRNA Translation: AAH04572.1
CCDSiCCDS19428.1
RefSeqiNP_001157159.1, NM_001163687.1
NP_080248.2, NM_025972.4
UniGeneiMm.28890

Genome annotation databases

EnsembliENSMUST00000113102; ENSMUSP00000108726; ENSMUSG00000029413
GeneIDi67111
KEGGimmu:67111
UCSCiuc008ycq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162194 mRNA Translation: BAD88530.1
AK008776 mRNA Translation: BAB25888.1
AK014438 mRNA Translation: BAB29350.2 Sequence problems.
BC004572 mRNA Translation: AAH04572.1
CCDSiCCDS19428.1
RefSeqiNP_001157159.1, NM_001163687.1
NP_080248.2, NM_025972.4
UniGeneiMm.28890

3D structure databases

ProteinModelPortaliQ9D7V9
SMRiQ9D7V9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D7V9, 2 interactors
MINTiQ9D7V9
STRINGi10090.ENSMUSP00000108726

Protein family/group databases

MEROPSiC89.002

Proteomic databases

EPDiQ9D7V9
MaxQBiQ9D7V9
PaxDbiQ9D7V9
PRIDEiQ9D7V9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113102; ENSMUSP00000108726; ENSMUSG00000029413
GeneIDi67111
KEGGimmu:67111
UCSCiuc008ycq.2 mouse

Organism-specific databases

CTDi27163
MGIiMGI:1914361 Naaa

Phylogenomic databases

eggNOGiENOG410IJHJ Eukaryota
ENOG4111HJY LUCA
GeneTreeiENSGT00530000063548
HOGENOMiHOG000007253
HOVERGENiHBG050586
InParanoidiQ9D7V9
KOiK13720
OMAiYESTAFC
OrthoDBiEOG091G0E3H
PhylomeDBiQ9D7V9
TreeFamiTF313219

Enzyme and pathway databases

BRENDAi3.5.1.4 3474
ReactomeiR-MMU-112310 Neurotransmitter release cycle

Miscellaneous databases

PROiPR:Q9D7V9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029413 Expressed in 218 organ(s), highest expression level in ventricular system choroidal fissure
ExpressionAtlasiQ9D7V9 baseline and differential
GenevisibleiQ9D7V9 MM

Family and domain databases

InterProiView protein in InterPro
IPR016699 Acid_ceramidase-like
IPR029130 Acid_ceramidase_N
IPR029132 CBAH/NAAA_C
PfamiView protein in Pfam
PF02275 CBAH, 1 hit
PF15508 NAAA-beta, 1 hit
PIRSFiPIRSF017632 Acid_ceramidase-like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAAA_MOUSE
AccessioniPrimary (citable) accession number: Q9D7V9
Secondary accession number(s): Q5KTC6, Q99KM3, Q9D6B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 12, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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