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Protein

SH2 domain-containing protein 4A

Gene

Sh2d4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4A
Gene namesi
Name:Sh2d4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919531 Sh2d4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331341 – 421SH2 domain-containing protein 4AAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei123PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D7V1
PaxDbiQ9D7V1
PeptideAtlasiQ9D7V1
PRIDEiQ9D7V1

PTM databases

iPTMnetiQ9D7V1
PhosphoSitePlusiQ9D7V1

Expressioni

Tissue specificityi

In the kidney, expressed only in the glomerulus. Expressed in T-cells, B-cells, macrophages and dendritic cells (at protein level). In adult, highest levels are found in muscle and lung with lower levels in kidney.2 Publications

Inductioni

Upon CD3/CD28 stimulation in CD4 T-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000053886 Expressed in 180 organ(s), highest expression level in epithelium of stomach
CleanExiMM_SH2D4A
ExpressionAtlasiQ9D7V1 baseline and differential
GenevisibleiQ9D7V1 MM

Interactioni

Subunit structurei

Interacts with ESR1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070825

Structurei

3D structure databases

ProteinModelPortaliQ9D7V1
SMRiQ9D7V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 407SH2PROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IEFY Eukaryota
ENOG410XPPJ LUCA
GeneTreeiENSGT00570000079047
HOGENOMiHOG000031527
HOVERGENiHBG057918
InParanoidiQ9D7V1
KOiK17577
OMAiYGFHQKK
OrthoDBiEOG091G08HG
PhylomeDBiQ9D7V1
TreeFamiTF336893

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D7V1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRQILSDMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE
60 70 80 90 100
SLPVKSRPKK ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE
110 120 130 140 150
REHLRAAKDS ELRKTQSLEL ANSLKIKSQN CDLQAMKKTE PQNVTRKAAS
160 170 180 190 200
EEASGQGPRA IPTRKDDKAQ TKPVKEKDHE EMKQTEDEKT KQIYKSWKED
210 220 230 240 250
SEWQASLRKS KAADEKRRSL AKQAREDYKR LSQRGRSGDG LQNPLTGPQK
260 270 280 290 300
PRRPPLPPKP QFLQPLGIPP KSLGNQGVIR TEISSAQMDT IRWFKEEQLP
310 320 330 340 350
FRAGYQKNSD TIAPWFHGIL TLKKANELLS TGVPGSFLIR VSEKIKGYAL
360 370 380 390 400
SYLSEEGCKH FLIDASANSY SFLGVDQLQH ATLADLVEYH KEEPITSLGK
410 420
ELLLYPCGQQ DKLPDYLELF Q
Length:421
Mass (Da):48,460
Last modified:June 1, 2001 - v1
Checksum:iEED076D6A1AE32D8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RMA9A0A1D5RMA9_MOUSE
SH2 domain-containing protein 4A
Sh2d4a
390Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283I → T in AAI16683 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008803 mRNA Translation: BAB25905.1
BC116682 mRNA Translation: AAI16683.1
CCDSiCCDS52564.1
RefSeqiNP_082458.1, NM_028182.1
XP_006509814.1, XM_006509751.3
UniGeneiMm.40974

Genome annotation databases

EnsembliENSMUST00000066594; ENSMUSP00000070825; ENSMUSG00000053886
GeneIDi72281
KEGGimmu:72281
UCSCiuc009lwe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008803 mRNA Translation: BAB25905.1
BC116682 mRNA Translation: AAI16683.1
CCDSiCCDS52564.1
RefSeqiNP_082458.1, NM_028182.1
XP_006509814.1, XM_006509751.3
UniGeneiMm.40974

3D structure databases

ProteinModelPortaliQ9D7V1
SMRiQ9D7V1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070825

PTM databases

iPTMnetiQ9D7V1
PhosphoSitePlusiQ9D7V1

Proteomic databases

MaxQBiQ9D7V1
PaxDbiQ9D7V1
PeptideAtlasiQ9D7V1
PRIDEiQ9D7V1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066594; ENSMUSP00000070825; ENSMUSG00000053886
GeneIDi72281
KEGGimmu:72281
UCSCiuc009lwe.2 mouse

Organism-specific databases

CTDi63898
MGIiMGI:1919531 Sh2d4a

Phylogenomic databases

eggNOGiENOG410IEFY Eukaryota
ENOG410XPPJ LUCA
GeneTreeiENSGT00570000079047
HOGENOMiHOG000031527
HOVERGENiHBG057918
InParanoidiQ9D7V1
KOiK17577
OMAiYGFHQKK
OrthoDBiEOG091G08HG
PhylomeDBiQ9D7V1
TreeFamiTF336893

Miscellaneous databases

ChiTaRSiSh2d4a mouse
PROiPR:Q9D7V1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053886 Expressed in 180 organ(s), highest expression level in epithelium of stomach
CleanExiMM_SH2D4A
ExpressionAtlasiQ9D7V1 baseline and differential
GenevisibleiQ9D7V1 MM

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSH24A_MOUSE
AccessioniPrimary (citable) accession number: Q9D7V1
Secondary accession number(s): Q14AV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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