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Protein

Claudin-22

Gene

Cldn22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-22
Gene namesi
Name:Cldn22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1922927 Cldn22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 81ExtracellularSequence analysisAdd BLAST50
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 120CytoplasmicSequence analysisAdd BLAST18
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 164ExtracellularSequence analysisAdd BLAST23
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 220CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447861 – 220Claudin-22Add BLAST220

Proteomic databases

PaxDbiQ9D7U6
PRIDEiQ9D7U6

Expressioni

Gene expression databases

BgeeiENSMUSG00000038064 Expressed in 94 organ(s), highest expression level in parotid gland
CleanExiMM_CLDN22
GenevisibleiQ9D7U6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041676

Structurei

3D structure databases

ProteinModelPortaliQ9D7U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INS5 Eukaryota
ENOG4111QE3 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG104065
InParanoidiQ9D7U6
KOiK06087
OMAiNYLPQWK
OrthoDBiEOG091G0QQ0
PhylomeDBiQ9D7U6
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D7U6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLVFRTATQ AAALLLSLLG WVLSCLTNYL PHWKNLNLEL NEMENWTMGL
60 70 80 90 100
WKSCVIQEEV GRQCKDFDSF LALPAELQVS RVLMSLCNGL GLLGLLASGC
110 120 130 140 150
GLDCLRLGET QEGLKKRLLT LGGTLLWTSG VMVLVPVSWV AHKTVREFWD
160 170 180 190 200
ETMPEIVPRW EFGEALFLGW FAGFCLVLGG CVLHCAACWS PAPAASSHYA
210 220
VAGPRDHQQH LELKQANPEI
Length:220
Mass (Da):24,310
Last modified:June 1, 2001 - v1
Checksum:iAA4EDB4959E3108E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008821 mRNA Translation: BAB25914.1
CCDSiCCDS52550.1
RefSeqiNP_083659.1, NM_029383.1
UniGeneiMm.390033

Genome annotation databases

EnsembliENSMUST00000038693; ENSMUSP00000041676; ENSMUSG00000038064
GeneIDi75677
KEGGimmu:75677
UCSCiuc012gdq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008821 mRNA Translation: BAB25914.1
CCDSiCCDS52550.1
RefSeqiNP_083659.1, NM_029383.1
UniGeneiMm.390033

3D structure databases

ProteinModelPortaliQ9D7U6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041676

Proteomic databases

PaxDbiQ9D7U6
PRIDEiQ9D7U6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038693; ENSMUSP00000041676; ENSMUSG00000038064
GeneIDi75677
KEGGimmu:75677
UCSCiuc012gdq.1 mouse

Organism-specific databases

CTDi53842
MGIiMGI:1922927 Cldn22

Phylogenomic databases

eggNOGiENOG410INS5 Eukaryota
ENOG4111QE3 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG104065
InParanoidiQ9D7U6
KOiK06087
OMAiNYLPQWK
OrthoDBiEOG091G0QQ0
PhylomeDBiQ9D7U6
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q9D7U6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038064 Expressed in 94 organ(s), highest expression level in parotid gland
CleanExiMM_CLDN22
GenevisibleiQ9D7U6 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD22_MOUSE
AccessioniPrimary (citable) accession number: Q9D7U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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