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Protein

Adipocyte plasma membrane-associated protein

Gene

Apmap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate (By similarity). May play a role in adipocyte differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Adipocyte plasma membrane-associated protein
Alternative name(s):
Protein DD16
Gene namesi
Name:Apmap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919131 Apmap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 39CytoplasmicSequence analysisAdd BLAST38
Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 415ExtracellularSequence analysisAdd BLAST355

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002059462 – 415Adipocyte plasma membrane-associated proteinAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei19PhosphothreonineBy similarity1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated in vitro.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9D7N9
MaxQBiQ9D7N9
PaxDbiQ9D7N9
PeptideAtlasiQ9D7N9
PRIDEiQ9D7N9

PTM databases

iPTMnetiQ9D7N9
PhosphoSitePlusiQ9D7N9
SwissPalmiQ9D7N9

Expressioni

Tissue specificityi

Strongly expressed in adipose tissue. Highly expressed in liver, heart, and kidney. Expressed at intermediate level in brain and lung. Weakly expressed in spleen, skeletal muscle and testis.

Developmental stagei

Expressed during adipocyte differentiation. Expression appears 3 days following induction of adipose conversion.

Gene expression databases

BgeeiENSMUSG00000033096 Expressed in 286 organ(s), highest expression level in decidua
CleanExiMM_2310001A20RIK
GenevisibleiQ9D7N9 MM

Interactioni

Protein-protein interaction databases

IntActiQ9D7N9, 5 interactors
MINTiQ9D7N9
STRINGi10090.ENSMUSP00000040840

Structurei

3D structure databases

ProteinModelPortaliQ9D7N9
SMRiQ9D7N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1520 Eukaryota
COG3386 LUCA
GeneTreeiENSGT00440000039984
HOGENOMiHOG000223914
HOVERGENiHBG050543
InParanoidiQ9D7N9
KOiK21407
OMAiTYISEVH
OrthoDBiEOG091G0C44
PhylomeDBiQ9D7N9
TreeFamiTF316475

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR018119 Strictosidine_synth_cons-reg
IPR004141 Strictosidine_synthase
PANTHERiPTHR10426 PTHR10426, 1 hit
PfamiView protein in Pfam
PF03088 Str_synth, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D7N9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEADGLRQR RPLRPQVVTD DGQVPEVKEG SSFSGRVFRM TFLMLAVSLA
60 70 80 90 100
IPLLGAMMLL ESPIDPQSFS FKEPPFMFGV LHPNTKLRQA ERLFENQLSG
110 120 130 140 150
PESIVNIGDV LFTGTADGRV VKLENGEIET IARFGSGPCK TRDDEPTCGR
160 170 180 190 200
PLGIRAGPNG TLFVVDAYKG LFEVNPQKRS VKLLLSSETP IEGKKMSFVN
210 220 230 240 250
DLTVTRDGRK IYFTDSSSKW QRRDYLLLVM EATDDGRLLE YDTVTKEVKV
260 270 280 290 300
LLDQLQFPNG VQLSPEEDFV LVAETTMARI RRVYVSGLMK GGADMFVENM
310 320 330 340 350
PGFPDNIRPS SSGGYWVAAA TIRANPGFSM LDFLSDKPFI KRMIFKMFSQ
360 370 380 390 400
ETVMKFVPRY SLVLEVSDSG AFRRSLHDPD GQVVTYVSEA HEHDGYLYLG
410
SFRSPFICRL SLQSI
Length:415
Mass (Da):46,434
Last modified:June 1, 2001 - v1
Checksum:i10BA522364CC03D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310638 mRNA Translation: CAC83967.1
AK009057 mRNA Translation: BAB26050.1
AK154266 mRNA Translation: BAE32477.1
AL845174 Genomic DNA Translation: CAM15679.1
CH466519 Genomic DNA Translation: EDL28569.1
BC055706 mRNA Translation: AAH55706.1
CCDSiCCDS16858.1
RefSeqiNP_082253.1, NM_027977.2
UniGeneiMm.26599

Genome annotation databases

EnsembliENSMUST00000046399; ENSMUSP00000040840; ENSMUSG00000033096
GeneIDi71881
KEGGimmu:71881
UCSCiuc008mud.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310638 mRNA Translation: CAC83967.1
AK009057 mRNA Translation: BAB26050.1
AK154266 mRNA Translation: BAE32477.1
AL845174 Genomic DNA Translation: CAM15679.1
CH466519 Genomic DNA Translation: EDL28569.1
BC055706 mRNA Translation: AAH55706.1
CCDSiCCDS16858.1
RefSeqiNP_082253.1, NM_027977.2
UniGeneiMm.26599

3D structure databases

ProteinModelPortaliQ9D7N9
SMRiQ9D7N9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D7N9, 5 interactors
MINTiQ9D7N9
STRINGi10090.ENSMUSP00000040840

PTM databases

iPTMnetiQ9D7N9
PhosphoSitePlusiQ9D7N9
SwissPalmiQ9D7N9

Proteomic databases

EPDiQ9D7N9
MaxQBiQ9D7N9
PaxDbiQ9D7N9
PeptideAtlasiQ9D7N9
PRIDEiQ9D7N9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046399; ENSMUSP00000040840; ENSMUSG00000033096
GeneIDi71881
KEGGimmu:71881
UCSCiuc008mud.1 mouse

Organism-specific databases

CTDi57136
MGIiMGI:1919131 Apmap

Phylogenomic databases

eggNOGiKOG1520 Eukaryota
COG3386 LUCA
GeneTreeiENSGT00440000039984
HOGENOMiHOG000223914
HOVERGENiHBG050543
InParanoidiQ9D7N9
KOiK21407
OMAiTYISEVH
OrthoDBiEOG091G0C44
PhylomeDBiQ9D7N9
TreeFamiTF316475

Miscellaneous databases

ChiTaRSiApmap mouse
PROiPR:Q9D7N9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033096 Expressed in 286 organ(s), highest expression level in decidua
CleanExiMM_2310001A20RIK
GenevisibleiQ9D7N9 MM

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR018119 Strictosidine_synth_cons-reg
IPR004141 Strictosidine_synthase
PANTHERiPTHR10426 PTHR10426, 1 hit
PfamiView protein in Pfam
PF03088 Str_synth, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPMAP_MOUSE
AccessioniPrimary (citable) accession number: Q9D7N9
Secondary accession number(s): A2AQX3, Q3U4F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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