Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane and immunoglobulin domain-containing protein 1

Gene

Tmigd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and immunoglobulin domain-containing protein 1
Gene namesi
Name:Tmigd1Imported
Synonyms:TmigdBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913851 Tmigd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 215ExtracellularSequence analysisAdd BLAST189
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 261CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004579127 – 261Transmembrane and immunoglobulin domain-containing protein 1Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 102PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 194PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D7L8
PaxDbiQ9D7L8
PRIDEiQ9D7L8

PTM databases

PhosphoSitePlusiQ9D7L8

Expressioni

Gene expression databases

BgeeiENSMUSG00000020839 Expressed in 117 organ(s), highest expression level in ileum
ExpressionAtlasiQ9D7L8 baseline and differential
GenevisibleiQ9D7L8 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072427

Structurei

3D structure databases

ProteinModelPortaliQ9D7L8
SMRiQ9D7L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 113Ig-like C2-type 1Add BLAST87
Domaini121 – 206Ig-like C2-type 2Add BLAST86

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG7 Eukaryota
ENOG41129HZ LUCA
GeneTreeiENSGT00510000048311
HOGENOMiHOG000154640
HOVERGENiHBG063617
InParanoidiQ9D7L8
OMAiIMKLCIK
OrthoDBiEOG091G0MG3
PhylomeDBiQ9D7L8
TreeFamiTF336634

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D7L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWKITGPLQ ACQLLLVVLS LPQGRTSSVL TVNGRTENYI LDTQHGVQAS
60 70 80 90 100
LECAVQNHTE DEELLWYRED GIVDLKNGNK INISSVCVSP INESDNGVRF
110 120 130 140 150
TCKLQRDQTV SVTVVLNVTF PPLLSGNGFQ TVEENSDVSL VCNVKSNPQA
160 170 180 190 200
QMMWYKNNSA LVLEKGRHQI HQTRESFQLS ITKVKKSDNG TYSCIASSSL
210 220 230 240 250
KMETMDFHLL VKDKVFVMPA EPIIAACVVV VLTMAFALFS RRKRIMKLCG
260
KKNDPNSETA L
Length:261
Mass (Da):29,051
Last modified:June 1, 2001 - v1
Checksum:i1FE1FC02D27E83CD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5NCR1Q5NCR1_MOUSE
Transmembrane and immunoglobulin do...
Tmigd1
140Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009118 mRNA Translation: BAB26083.1
AL603842 Genomic DNA No translation available.
BC022683 mRNA Translation: AAH22683.1
BC061082 mRNA Translation: AAH61082.1
CCDSiCCDS25072.1
RefSeqiNP_079931.1, NM_025655.2
XP_006534010.2, XM_006533947.3
XP_006534013.1, XM_006533950.2
UniGeneiMm.25138

Genome annotation databases

EnsembliENSMUST00000072633; ENSMUSP00000072427; ENSMUSG00000020839
ENSMUST00000102495; ENSMUSP00000099553; ENSMUSG00000020839
GeneIDi66601
KEGGimmu:66601
UCSCiuc007kgc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009118 mRNA Translation: BAB26083.1
AL603842 Genomic DNA No translation available.
BC022683 mRNA Translation: AAH22683.1
BC061082 mRNA Translation: AAH61082.1
CCDSiCCDS25072.1
RefSeqiNP_079931.1, NM_025655.2
XP_006534010.2, XM_006533947.3
XP_006534013.1, XM_006533950.2
UniGeneiMm.25138

3D structure databases

ProteinModelPortaliQ9D7L8
SMRiQ9D7L8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072427

PTM databases

PhosphoSitePlusiQ9D7L8

Proteomic databases

MaxQBiQ9D7L8
PaxDbiQ9D7L8
PRIDEiQ9D7L8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072633; ENSMUSP00000072427; ENSMUSG00000020839
ENSMUST00000102495; ENSMUSP00000099553; ENSMUSG00000020839
GeneIDi66601
KEGGimmu:66601
UCSCiuc007kgc.1 mouse

Organism-specific databases

CTDi388364
MGIiMGI:1913851 Tmigd1

Phylogenomic databases

eggNOGiENOG410IJG7 Eukaryota
ENOG41129HZ LUCA
GeneTreeiENSGT00510000048311
HOGENOMiHOG000154640
HOVERGENiHBG063617
InParanoidiQ9D7L8
OMAiIMKLCIK
OrthoDBiEOG091G0MG3
PhylomeDBiQ9D7L8
TreeFamiTF336634

Miscellaneous databases

PROiPR:Q9D7L8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020839 Expressed in 117 organ(s), highest expression level in ileum
ExpressionAtlasiQ9D7L8 baseline and differential
GenevisibleiQ9D7L8 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTMIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D7L8
Secondary accession number(s): Q8R202
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again