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UniProtKB - Q9D7J9 (ECHD3_MOUSE)
Protein
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial
Gene
Echdc3
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in fatty acid biosynthesis and insulin sensitivity.
By similarityGO - Molecular functioni
- enoyl-CoA hydratase activity Source: UniProtKB
- hydro-lyase activity Source: GO_Central
GO - Biological processi
- fatty acid metabolic process Source: UniProtKB
- positive regulation of cellular response to insulin stimulus Source: MGI
Keywordsi
Biological process | Fatty acid metabolism, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Enoyl-CoA hydratase domain-containing protein 3, mitochondrialCurated |
Gene namesi | Name:Echdc3Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915106, Echdc3 |
VEuPathDBi | HostDB:ENSMUSG00000039063 |
Subcellular locationi
Mitochondrion
- Mitochondrion Curated
Mitochondrion
- mitochondrion Source: MGI
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 66 | MitochondrionSequence analysisAdd BLAST | 66 | |
ChainiPRO_0000333216 | 67 – 300 | Enoyl-CoA hydratase domain-containing protein 3, mitochondrialAdd BLAST | 234 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | N6-succinyllysineCombined sources | 1 |
Proteomic databases
jPOSTi | Q9D7J9 |
MaxQBi | Q9D7J9 |
PaxDbi | Q9D7J9 |
PeptideAtlasi | Q9D7J9 |
PRIDEi | Q9D7J9 |
ProteomicsDBi | 277627 |
PTM databases
iPTMneti | Q9D7J9 |
PhosphoSitePlusi | Q9D7J9 |
SwissPalmi | Q9D7J9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039063, Expressed in liver and 216 other tissues |
Genevisiblei | Q9D7J9, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 212484, 2 interactors |
STRINGi | 10090.ENSMUSP00000037371 |
Miscellaneous databases
RNActi | Q9D7J9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 53 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the enoyl-CoA hydratase/isomerase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1682, Eukaryota |
GeneTreei | ENSGT00940000157926 |
HOGENOMi | CLU_009834_7_3_1 |
InParanoidi | Q9D7J9 |
OMAi | SCDMVVC |
OrthoDBi | 804458at2759 |
PhylomeDBi | Q9D7J9 |
TreeFami | TF313089 |
Family and domain databases
Gene3Di | 1.10.12.10, 1 hit |
InterProi | View protein in InterPro IPR029045, ClpP/crotonase-like_dom_sf IPR001753, Enoyl-CoA_hydra/iso IPR014748, Enoyl-CoA_hydra_C |
Pfami | View protein in Pfam PF00378, ECH_1, 1 hit |
SUPFAMi | SSF52096, SSF52096, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9D7J9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVVAGLRAF GVKWPSWLRR NPWAPLSAGF CSPGSAGPAG SESEPRLTST
60 70 80 90 100
RQQDGIRNIV LSNPRRRNAL SLAMLKSLRS DILHEAESED LKVIIISAEG
110 120 130 140 150
PVFSSGHDLK ELTDAQGRDY HAEVFQTCSE VMMLIRNHPV PILAMVNGLA
160 170 180 190 200
TAAGCQLVAS CDIAVASDKS SFATPGVNVG LFCSTPAVAL GRAVPRKVAL
210 220 230 240 250
EMLFTGEPIS AQEALRHGLI SKVVPEEQLE AETMRIAKKI SSLSRSVVAL
260 270 280 290 300
GKATFYKQLP QDLRTAYFLA SQAMVDNLAL QDGQEGIEAF IQKRKPIWSH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | T → M in AAH02214 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 227 | E → G in AAH02214 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK009166 mRNA Translation: BAB26117.1 AL845275 Genomic DNA No translation available. AL928735 Genomic DNA No translation available. BC002214 mRNA Translation: AAH02214.1 BC054365 mRNA Translation: AAH54365.1 |
CCDSi | CCDS15672.1 |
RefSeqi | NP_077170.2, NM_024208.4 |
Genome annotation databases
Ensembli | ENSMUST00000042658; ENSMUSP00000037371; ENSMUSG00000039063 |
GeneIDi | 67856 |
KEGGi | mmu:67856 |
UCSCi | uc008igi.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK009166 mRNA Translation: BAB26117.1 AL845275 Genomic DNA No translation available. AL928735 Genomic DNA No translation available. BC002214 mRNA Translation: AAH02214.1 BC054365 mRNA Translation: AAH54365.1 |
CCDSi | CCDS15672.1 |
RefSeqi | NP_077170.2, NM_024208.4 |
3D structure databases
AlphaFoldDBi | Q9D7J9 |
SMRi | Q9D7J9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212484, 2 interactors |
STRINGi | 10090.ENSMUSP00000037371 |
PTM databases
iPTMneti | Q9D7J9 |
PhosphoSitePlusi | Q9D7J9 |
SwissPalmi | Q9D7J9 |
Proteomic databases
jPOSTi | Q9D7J9 |
MaxQBi | Q9D7J9 |
PaxDbi | Q9D7J9 |
PeptideAtlasi | Q9D7J9 |
PRIDEi | Q9D7J9 |
ProteomicsDBi | 277627 |
Protocols and materials databases
Antibodypediai | 24584, 35 antibodies from 15 providers |
Genome annotation databases
Ensembli | ENSMUST00000042658; ENSMUSP00000037371; ENSMUSG00000039063 |
GeneIDi | 67856 |
KEGGi | mmu:67856 |
UCSCi | uc008igi.1, mouse |
Organism-specific databases
CTDi | 79746 |
MGIi | MGI:1915106, Echdc3 |
VEuPathDBi | HostDB:ENSMUSG00000039063 |
Phylogenomic databases
eggNOGi | KOG1682, Eukaryota |
GeneTreei | ENSGT00940000157926 |
HOGENOMi | CLU_009834_7_3_1 |
InParanoidi | Q9D7J9 |
OMAi | SCDMVVC |
OrthoDBi | 804458at2759 |
PhylomeDBi | Q9D7J9 |
TreeFami | TF313089 |
Miscellaneous databases
BioGRID-ORCSi | 67856, 1 hit in 72 CRISPR screens |
PROi | PR:Q9D7J9 |
RNActi | Q9D7J9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039063, Expressed in liver and 216 other tissues |
Genevisiblei | Q9D7J9, MM |
Family and domain databases
Gene3Di | 1.10.12.10, 1 hit |
InterProi | View protein in InterPro IPR029045, ClpP/crotonase-like_dom_sf IPR001753, Enoyl-CoA_hydra/iso IPR014748, Enoyl-CoA_hydra_C |
Pfami | View protein in Pfam PF00378, ECH_1, 1 hit |
SUPFAMi | SSF52096, SSF52096, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ECHD3_MOUSE | |
Accessioni | Q9D7J9Primary (citable) accession number: Q9D7J9 Secondary accession number(s): Q99LV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families