UniProtKB - Q9D7J6 (DNSL1_MOUSE)
Protein
Deoxyribonuclease-1-like 1
Gene
Dnase1l1
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 113 | By similarity | 1 | |
Active sitei | 164 | By similarity | 1 |
GO - Molecular functioni
- deoxyribonuclease activity Source: GO_Central
- deoxyribonuclease I activity Source: GO_Central
- DNA binding Source: GO_Central
GO - Biological processi
- DNA catabolic process Source: GO_Central
- DNA catabolic process, endonucleolytic Source: GO_Central
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Deoxyribonuclease-1-like 1 (EC:3.1.21.-)Alternative name(s): DNase X Deoxyribonuclease I-like 1 Short name: DNase I-like 1 |
Gene namesi | Name:Dnase1l1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109628, Dnase1l1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 37 | Sequence analysisAdd BLAST | 37 | |
ChainiPRO_0000007285 | 38 – 314 | Deoxyribonuclease-1-like 1Add BLAST | 277 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 133 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 203 ↔ 240 | Essential for enzymatic activityBy similarity | ||
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q9D7J6 |
PaxDbi | Q9D7J6 |
PRIDEi | Q9D7J6 |
PTM databases
GlyGeni | Q9D7J6, 3 sites |
PhosphoSitePlusi | Q9D7J6 |
Expressioni
Tissue specificityi
Highly expressed in heart and skeletal muscles. Low expression in brain and thymus. Intermediated expression in other tissues.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000019088, Expressed in bone marrow macrophage and 54 other tissues |
ExpressionAtlasi | Q9D7J6, baseline and differential |
Genevisiblei | Q9D7J6, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019232 |
Miscellaneous databases
RNActi | Q9D7J6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DNase I family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QQFT, Eukaryota |
GeneTreei | ENSGT00950000182846 |
HOGENOMi | CLU_043335_1_0_1 |
InParanoidi | Q9D7J6 |
OMAi | FHWAIAD |
OrthoDBi | 1282784at2759 |
PhylomeDBi | Q9D7J6 |
TreeFami | TF329541 |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR018057, Deoxyribonuclease-1_AS IPR016202, DNase_I IPR033125, DNASE_I_2 IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
PIRSFi | PIRSF000988, DNase_I_euk, 1 hit |
PRINTSi | PR00130, DNASEI |
SMARTi | View protein in SMART SM00476, DNaseIc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
PROSITEi | View protein in PROSITE PS00919, DNASE_I_1, 1 hit PS00918, DNASE_I_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9D7J6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPFGQPGFLW RVPDAHIAMR GLVMAPLLIL LVGGTEAFRI CAFNAHRLTL
60 70 80 90 100
AKLTKESVMD TLVQILARCD IMVLQEVVDS SQNTVPFLLQ KLKSSRSYSF
110 120 130 140 150
LNSSLLGRST YKEKYVYIYR SDKTQVLNFY QYNDTDDIFA REPFVAHFTL
160 170 180 190 200
PSKTLPSVVL VPLHTTPKDV EKELNALYDV FLDVYQRWQN ENVILLGDFN
210 220 230 240 250
ADCASLTKKR LKSLLLRTKA GFHWVIPDGE DTTVRASTNC TYDRIVVHGQ
260 270 280 290 300
GCQMLLKAAA TFDFPKRFQL TEEEALRISD HYPVEVELSQ ATPLSIPPHY
310
LAALLLSLLP SQLD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8MWW4 | A0A6I8MWW4_MOUSE | Deoxyribonuclease | Dnase1l1 | 296 | Annotation score: | ||
J9JI68 | J9JI68_MOUSE | Deoxyribonuclease-1-like 1 | Dnase1l1 | 64 | Annotation score: | ||
J9JI65 | J9JI65_MOUSE | Deoxyribonuclease-1-like 1 | Dnase1l1 | 86 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ116784 mRNA Translation: AAZ94277.1 AK009174 mRNA Translation: BAB26122.1 AK150242 mRNA Translation: BAE29406.1 BC023246 mRNA Translation: AAH23246.1 |
RefSeqi | NP_001165625.1, NM_001172154.1 NP_081385.1, NM_027109.2 |
Genome annotation databases
Ensembli | ENSMUST00000019232; ENSMUSP00000019232; ENSMUSG00000019088 ENSMUST00000239445; ENSMUSP00000159293; ENSMUSG00000019088 |
GeneIDi | 69537 |
KEGGi | mmu:69537 |
UCSCi | uc009tof.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ116784 mRNA Translation: AAZ94277.1 AK009174 mRNA Translation: BAB26122.1 AK150242 mRNA Translation: BAE29406.1 BC023246 mRNA Translation: AAH23246.1 |
RefSeqi | NP_001165625.1, NM_001172154.1 NP_081385.1, NM_027109.2 |
3D structure databases
SMRi | Q9D7J6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019232 |
PTM databases
GlyGeni | Q9D7J6, 3 sites |
PhosphoSitePlusi | Q9D7J6 |
Proteomic databases
MaxQBi | Q9D7J6 |
PaxDbi | Q9D7J6 |
PRIDEi | Q9D7J6 |
Protocols and materials databases
Antibodypediai | 31202, 162 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000019232; ENSMUSP00000019232; ENSMUSG00000019088 ENSMUST00000239445; ENSMUSP00000159293; ENSMUSG00000019088 |
GeneIDi | 69537 |
KEGGi | mmu:69537 |
UCSCi | uc009tof.2, mouse |
Organism-specific databases
CTDi | 1774 |
MGIi | MGI:109628, Dnase1l1 |
Phylogenomic databases
eggNOGi | ENOG502QQFT, Eukaryota |
GeneTreei | ENSGT00950000182846 |
HOGENOMi | CLU_043335_1_0_1 |
InParanoidi | Q9D7J6 |
OMAi | FHWAIAD |
OrthoDBi | 1282784at2759 |
PhylomeDBi | Q9D7J6 |
TreeFami | TF329541 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 69537, 1 hit in 17 CRISPR screens |
ChiTaRSi | Dnase1l1, mouse |
PROi | PR:Q9D7J6 |
RNActi | Q9D7J6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019088, Expressed in bone marrow macrophage and 54 other tissues |
ExpressionAtlasi | Q9D7J6, baseline and differential |
Genevisiblei | Q9D7J6, MM |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR018057, Deoxyribonuclease-1_AS IPR016202, DNase_I IPR033125, DNASE_I_2 IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
PIRSFi | PIRSF000988, DNase_I_euk, 1 hit |
PRINTSi | PR00130, DNASEI |
SMARTi | View protein in SMART SM00476, DNaseIc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
PROSITEi | View protein in PROSITE PS00919, DNASE_I_1, 1 hit PS00918, DNASE_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNSL1_MOUSE | |
Accessioni | Q9D7J6Primary (citable) accession number: Q9D7J6 Secondary accession number(s): Q3UD56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | April 4, 2006 | |
Last modified: | February 10, 2021 | |
This is version 132 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families