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Protein

Serpin A9

Gene

Serpina9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A9
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919157 Serpina9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004197226 – 418Serpin A9Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D7D2
PRIDEiQ9D7D2

PTM databases

iPTMnetiQ9D7D2
PhosphoSitePlusiQ9D7D2

Expressioni

Gene expression databases

BgeeiENSMUSG00000058260 Expressed in 46 organ(s), highest expression level in dorsal striatum
ExpressionAtlasiQ9D7D2 baseline and differential
GenevisibleiQ9D7D2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058535

Structurei

3D structure databases

ProteinModelPortaliQ9D7D2
SMRiQ9D7D2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ9D7D2
KOiK04525
OMAiPKMGIRD
OrthoDBiEOG091G0ION
PhylomeDBiQ9D7D2
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9D7D2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSSFYRVL LLVGFCAPIF CMLSSNPYNQ ESSHLPSMKK NPASQVSPSN
60 70 80 90 100
TRFSFLLYQR LAQENPGQNI LFSPVSISTS LAMLSLGARS ATKTQILRTL
110 120 130 140 150
GFNFTWVSEP TIHMGFEYLV RSLNKCHQGR ELRMGSVLFI RKELQLQATF
160 170 180 190 200
LDRVKKLYGA KVFSEDFSNA ATAQAQINSY VEKETKGKVV DVIQDLDSQT
210 220 230 240 250
AMVLVNHIFF KANWTQPFST ANTNKSFPFL LSKGTTVHVP MMHQTESFAF
260 270 280 290 300
GVDKELGCSI LQMDYRGDAV AFFVLPGKGK MRQLEKSLSA RRLRKWSRSL
310 320 330 340 350
QKRWIKVFIP KFSISASYNL ETILPKMGIR DAFNSNADFS GITKTHFLQV
360 370 380 390 400
SKAAHKAVLD VSEEGTEAAA ATTTKLIVRS RDTPSSIIAF KEPFLILLLD
410
KNTESVLFLG KVENPRKM
Length:418
Mass (Da):46,894
Last modified:June 1, 2001 - v1
Checksum:i4CFA144E99381D2D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q865E9Q865_MOUSE
Serpin A9
Serpina9
205Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009343 mRNA Translation: BAB26230.1
CCDSiCCDS26144.1
RefSeqiNP_082273.1, NM_027997.2
XP_006516304.1, XM_006516241.1
XP_006516305.1, XM_006516242.2
UniGeneiMm.326723

Genome annotation databases

EnsembliENSMUST00000058464; ENSMUSP00000058535; ENSMUSG00000058260
GeneIDi71907
KEGGimmu:71907
UCSCiuc007owo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009343 mRNA Translation: BAB26230.1
CCDSiCCDS26144.1
RefSeqiNP_082273.1, NM_027997.2
XP_006516304.1, XM_006516241.1
XP_006516305.1, XM_006516242.2
UniGeneiMm.326723

3D structure databases

ProteinModelPortaliQ9D7D2
SMRiQ9D7D2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058535

PTM databases

iPTMnetiQ9D7D2
PhosphoSitePlusiQ9D7D2

Proteomic databases

PaxDbiQ9D7D2
PRIDEiQ9D7D2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058464; ENSMUSP00000058535; ENSMUSG00000058260
GeneIDi71907
KEGGimmu:71907
UCSCiuc007owo.1 mouse

Organism-specific databases

CTDi327657
MGIiMGI:1919157 Serpina9

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ9D7D2
KOiK04525
OMAiPKMGIRD
OrthoDBiEOG091G0ION
PhylomeDBiQ9D7D2
TreeFamiTF343201

Miscellaneous databases

PROiPR:Q9D7D2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058260 Expressed in 46 organ(s), highest expression level in dorsal striatum
ExpressionAtlasiQ9D7D2 baseline and differential
GenevisibleiQ9D7D2 MM

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPA9_MOUSE
AccessioniPrimary (citable) accession number: Q9D7D2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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