Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM and senescent cell antigen-like-containing domain protein

Gene

Lims1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain proteinUniRule annotation
Gene namesi
Name:Lims1Imported
ORF Names:mCG_19016Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1195263 Lims1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junctionUniRule annotation, Cell membraneUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000019920

Interactioni

Subunit structurei

Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.UniRule annotation

Protein-protein interaction databases

IntActiQ9D7B2, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 131LIM zinc-bindingInterPro annotationAdd BLAST62
Domaini133 – 190LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini195 – 252LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini253 – 312LIM zinc-bindingInterPro annotationAdd BLAST60
Domaini313 – 372LIM zinc-bindingInterPro annotationAdd BLAST60

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
HOVERGENiHBG000053
OrthoDBiEOG091G08K3

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q9D7B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPGRARPC TIPENEEIPQ TALNSVLEAN GNEDERAVSN LQRRHSDVKV
60 70 80 90 100
YKEFCDFYAK FNMANALASA TCERCKGGFA PAEKIVNSNG ELYHEQCFVC
110 120 130 140 150
AQCFQQFPEG LFYEFEGRKY CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN
160 170 180 190 200
SWHPECFRCD LCQEVLADIG FVKNAGRHLC RPCHNREKAR GLGKYICQKC
210 220 230 240 250
HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE LYCLPCHDKM
260 270 280 290 300
GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA
310 320 330 340 350
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVSCFAC STCNTKLTLK
360 370 380 390
DKFVEIDLKP VCKYCYEKMP EEFKRRLAKR EREAKDKDKQ RKRKPV
Length:396
Mass (Da):45,593
Last modified:March 1, 2003 - v2
Checksum:i04A41500BD48A4C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155323 Genomic DNA No translation available.
AK009390 mRNA Translation: BAB26259.2
CH466685 Genomic DNA Translation: EDL42132.1
RefSeqiNP_001180232.1, NM_001193303.1
UniGeneiMm.402697
Mm.482932
Mm.57734

Genome annotation databases

EnsembliENSMUST00000020077; ENSMUSP00000020077; ENSMUSG00000019920
GeneIDi110829
UCSCiuc007fda.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ9D7B2_MOUSE
AccessioniPrimary (citable) accession number: Q9D7B2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health