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Protein

Methionyl-tRNA formyltransferase, mitochondrial

Gene

Mtfmt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).By similarity

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

GO - Molecular functioni

  • methionyl-tRNA formyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase, mitochondrial (EC:2.1.2.9)
Short name:
MtFMT
Gene namesi
Name:Mtfmt
Synonyms:Fmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916856 Mtfmt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010094? – 386Methionyl-tRNA formyltransferase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9D799
MaxQBiQ9D799
PaxDbiQ9D799
PRIDEiQ9D799

PTM databases

iPTMnetiQ9D799
PhosphoSitePlusiQ9D799

Expressioni

Gene expression databases

BgeeiENSMUSG00000059183 Expressed in 253 organ(s), highest expression level in humerus cartilage element
CleanExiMM_MTFMT
GenevisibleiQ9D799 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074347

Structurei

3D structure databases

ProteinModelPortaliQ9D799
SMRiQ9D799
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction.

Sequence similaritiesi

Belongs to the Fmt family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3082 Eukaryota
COG0223 LUCA
GeneTreeiENSGT00390000017828
HOGENOMiHOG000261177
HOVERGENiHBG031552
InParanoidiQ9D799
KOiK00604
OMAiNFYKYKR
OrthoDBiEOG091G0QUP
TreeFamiTF323405

Family and domain databases

InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D799-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLPRCCWGR WLMGRRPRCS CQAPAGFDGK DGRGSRVREK PPWRVLFLGT
60 70 80 90 100
DHFARETLRA LHAARDGKEE KLIEKLEVVT VPSLSPKGLP VKQYAIQSQL
110 120 130 140 150
PVYEWPDVGS GEYDVGVVAS FGRLLSEALI LKFPYGILNV HPSCLPRWRG
160 170 180 190 200
PAPIIHTVLH GDTVTGVTIM QIRPKRFDIG PILQQETIPV PPKSTSKELE
210 220 230 240 250
AVLSKLGANM LISVLKNLPE SLNNGRPQPA EGVTYAPKVS AGTSCVKWEE
260 270 280 290 300
QTSEQVLRLH LAIGDIVPLQ TLWMENTVKL LDLVEVNNSI LADPKLTGQT
310 320 330 340 350
VTPGFVVYHR PSQMLLVRCK DGWIGVRSVM LKKTLTATDF YNGYLHAWYQ
360 370 380
KNSHAHPSQC RFQTLRLPTK MQQKTKLLLC NSALSS
Length:386
Mass (Da):43,092
Last modified:July 27, 2011 - v3
Checksum:i74B0542C0ECA4D9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40K → M in BAB26282 (PubMed:16141072).Curated1
Sequence conflicti305F → S in AAH19509 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009430 mRNA Translation: BAB26282.1
AC114645 Genomic DNA No translation available.
BC019509 mRNA Translation: AAH19509.1
CCDSiCCDS23292.1
RefSeqiNP_081410.2, NM_027134.3
UniGeneiMm.287956

Genome annotation databases

EnsembliENSMUST00000074792; ENSMUSP00000074347; ENSMUSG00000059183
GeneIDi69606
KEGGimmu:69606
UCSCiuc009qdh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009430 mRNA Translation: BAB26282.1
AC114645 Genomic DNA No translation available.
BC019509 mRNA Translation: AAH19509.1
CCDSiCCDS23292.1
RefSeqiNP_081410.2, NM_027134.3
UniGeneiMm.287956

3D structure databases

ProteinModelPortaliQ9D799
SMRiQ9D799
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074347

PTM databases

iPTMnetiQ9D799
PhosphoSitePlusiQ9D799

Proteomic databases

EPDiQ9D799
MaxQBiQ9D799
PaxDbiQ9D799
PRIDEiQ9D799

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074792; ENSMUSP00000074347; ENSMUSG00000059183
GeneIDi69606
KEGGimmu:69606
UCSCiuc009qdh.2 mouse

Organism-specific databases

CTDi123263
MGIiMGI:1916856 Mtfmt

Phylogenomic databases

eggNOGiKOG3082 Eukaryota
COG0223 LUCA
GeneTreeiENSGT00390000017828
HOGENOMiHOG000261177
HOVERGENiHBG031552
InParanoidiQ9D799
KOiK00604
OMAiNFYKYKR
OrthoDBiEOG091G0QUP
TreeFamiTF323405

Miscellaneous databases

PROiPR:Q9D799
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059183 Expressed in 253 organ(s), highest expression level in humerus cartilage element
CleanExiMM_MTFMT
GenevisibleiQ9D799 MM

Family and domain databases

InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFMT_MOUSE
AccessioniPrimary (citable) accession number: Q9D799
Secondary accession number(s): E9QKZ0, Q8VE89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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