Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 13

Gene

Tnfsf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.1 Publication

Miscellaneous

Transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B-cell population. Aging transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into non-lymphoid tissues such as kidney and liver (PubMed:15488762).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 13
Alternative name(s):
A proliferation-inducing ligand
Short name:
APRIL
CD_antigen: CD256
Gene namesi
Name:Tnfsf13
Synonyms:April
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916833 Tnfsf13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000345261 – 95By similarityAdd BLAST95
ChainiPRO_000003452796 – 241Tumor necrosis factor ligand superfamily member 13Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi187 ↔ 2021 Publication

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei95 – 96Cleavage; by furinBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D777
PaxDbiQ9D777
PRIDEiQ9D777

PTM databases

PhosphoSitePlusiQ9D777

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D777, 2 interactors
STRINGi10090.ENSMUSP00000018896

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9D777
SMRiQ9D777
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D777

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Phylogenomic databases

eggNOGiENOG410II60 Eukaryota
ENOG410Y4KC LUCA
HOGENOMiHOG000036810
HOVERGENiHBG104367
InParanoidiQ9D777
KOiK05475
PhylomeDBiQ9D777

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9D777-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPASSPGHMG GSVREPALSV ALWLSWGAVL GAVTCAVALL IQQTELQSLR
60 70 80 90 100
REVSRLQRSG GPSQKQGERP WQSLWEQSPD VLEAWKDGAK SRRRRAVLTQ
110 120 130 140 150
KHKKKHSVLH LVPVNITSKA DSDVTEVMWQ PVLRRGRGLE AQGDIVRVWD
160 170 180 190 200
TGIYLLYSQV LFHDVTFTMG QVVSREGQGR RETLFRCIRS MPSDPDRAYN
210 220 230 240
SCYSAGVFHL HQGDIITVKI PRANAKLSLS PHGTFLGFVK L
Length:241
Mass (Da):26,889
Last modified:June 1, 2001 - v1
Checksum:i4B96D03BDBC712A4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5F2A4Q5F2A4_MOUSE
Tumor necrosis factor ligand superf...
Tnfsf13
240Annotation score:
Q5F2A3Q5F2A3_MOUSE
Tumor necrosis factor ligand superf...
Tnfsf13
224Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120Missing in AAG22534 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294825 mRNA Translation: AAG22534.1
AK009514 mRNA Translation: BAB26332.1
BC069900 mRNA Translation: AAH69900.1
RefSeqiNP_001152977.1, NM_001159505.1
NP_076006.2, NM_023517.2
UniGeneiMm.8983

Genome annotation databases

GeneIDi69583
KEGGimmu:69583
UCSCiuc007jrd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294825 mRNA Translation: AAG22534.1
AK009514 mRNA Translation: BAB26332.1
BC069900 mRNA Translation: AAH69900.1
RefSeqiNP_001152977.1, NM_001159505.1
NP_076006.2, NM_023517.2
UniGeneiMm.8983

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U5XX-ray1.80A104-241[»]
1U5YX-ray2.30A/B/D104-241[»]
1U5ZX-ray2.40A104-241[»]
1XU1X-ray1.90A/B/D104-241[»]
1XU2X-ray2.35A/B/D104-241[»]
3K48X-ray2.80A/B/D104-241[»]
ProteinModelPortaliQ9D777
SMRiQ9D777
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D777, 2 interactors
STRINGi10090.ENSMUSP00000018896

PTM databases

PhosphoSitePlusiQ9D777

Proteomic databases

MaxQBiQ9D777
PaxDbiQ9D777
PRIDEiQ9D777

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69583
KEGGimmu:69583
UCSCiuc007jrd.1 mouse

Organism-specific databases

CTDi8741
MGIiMGI:1916833 Tnfsf13

Phylogenomic databases

eggNOGiENOG410II60 Eukaryota
ENOG410Y4KC LUCA
HOGENOMiHOG000036810
HOVERGENiHBG104367
InParanoidiQ9D777
KOiK05475
PhylomeDBiQ9D777

Miscellaneous databases

EvolutionaryTraceiQ9D777
PROiPR:Q9D777
SOURCEiSearch...

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNF13_MOUSE
AccessioniPrimary (citable) accession number: Q9D777
Secondary accession number(s): Q9ERP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again